Examples


Induced Subgraph Molecules and their Interacting Proteins


Interaction data from BioGRID, Reactome and IntAct

Download Data

All molecules displayed are selected based on the significance criteria.

Gene ID A
Gene Symbol A
UniProt id A
Gene ID B
Gene Symbol B
UniProt id B
Interaction Type
Reference-pmid
19
ABCA1
O95477
335
APOA1
P02647
direct interaction
12084722
5243
ABCB1
P08183
5292
PIM1
P11309
physical association
20460432
25
ABL1
P00519
7157
TP53
P04637
direct interaction
10629029
25
ABL1
P00519
472
ATM
Q13315
direct interaction
9168117
25
ABL1
P00519
472
ATM
Q13315
physical association
9168117
25
ABL1
P00519
5925
RB1
P06400
physical association
9071815
25
ABL1
P00519
6464
SHC1
P29353
physical association
8112292
25
ABL1
P00519
472
ATM
Q13315
physical association
10212258
25
ABL1
P00519
6714
SRC
P12931
direct interaction
11494128
25
ABL1
P00519
5888
RAD51
Q06609
direct interaction
10212258
25
ABL1
P00519
25
ABL1
P00519
direct interaction
12654250
25
ABL1
P00519
5295
PIK3R1
P27986
direct interaction
8294442
25
ABL1
P00519
5888
RAD51
Q06609
physical association
10212258
25
ABL1
P00519
5111
PCNA
P12004
physical association
22238610
25
ABL1
P00519
5295
PIK3R1
P27986
physical association
19380743
25
ABL1
P00519
6464
SHC1
P29353
physical association
19380743
25
ABL1
P00519
1173
AP2M1
Q96CW1
physical association
19380743
25
ABL1
P00519
472
ATM
Q13315
physical association
11375976
25
ABL1
P00519
3716
JAK1
P23458
direct interaction
9774693
25
ABL1
P00519
5888
RAD51
Q06609
physical association
10212258
25
ABL1
P00519
4137
MAPT
P10636
direct interaction
18070606
25
ABL1
P00519
6464
SHC1
P29353
physical association
19380743
25
ABL1
P00519
2475
MTOR
P42345
physical association
10753870
25
ABL1
P00519
4193
MDM2
Q00987
direct interaction
12110584
25
ABL1
P00519
4193
MDM2
Q00987
physical association
12110584
60
ACTB
P60709
60
ACTB
P60709
direct interaction
9209005
60
ACTB
P60709
1490
CTGF
P29279
physical association
12470643
60
ACTB
P60709
60
ACTB
P60709
direct interaction
16189514
60
ACTB
P60709
2099
ESR1
P03372
physical association
20308691
60
ACTB
P60709
60
ACTB
P60709
physical association
16189514
87
ACTN1
P12814
87
ACTN1
P12814
association
11470434
87
ACTN1
P12814
5585
PKN1
Q16512
physical association
11802708
81
ACTN4
O43707
2099
ESR1
P03372
physical association
21078666
81
ACTN4
O43707
2099
ESR1
P03372
direct interaction
21078666
207
AKT1
P31749
6416
MAP2K4
P45985
physical association
15998799
207
AKT1
P31749
3164
NR4A1
P22736
physical association
11274386
207
AKT1
P31749
3164
NR4A1
P22736
direct interaction
11274386
207
AKT1
P31749
572
BAD
Q92934
physical association
15998799
207
AKT1
P31749
572
BAD
Q92934
direct interaction
15998799
207
AKT1
P31749
1027
CDKN1B
P46527
direct interaction
12042314
207
AKT1
P31749
4193
MDM2
Q00987
physical association
11715018
207
AKT1
P31749
4193
MDM2
Q00987
direct interaction
11715018
207
AKT1
P31749
673
BRAF
P15056
physical association
10869359
207
AKT1
P31749
673
BRAF
P15056
direct interaction
10869359
207
AKT1
P31749
4193
MDM2
Q00987
direct interaction
11923280
207
AKT1
P31749
2931
GSK3A
P49840
direct interaction
11509608
207
AKT1
P31749
1432
MAPK14
Q16539
physical association
11042204
207
AKT1
P31749
1111
CHEK1
O14757
physical association
17962807
207
AKT1
P31749
3615
IMPDH2
P12268
direct interaction
10930578
207
AKT1
P31749
3615
IMPDH2
P12268
physical association
10930578
207
AKT1
P31749
1786
DNMT1
P26358
physical association
21151116
207
AKT1
P31749
1786
DNMT1
P26358
direct interaction
21151116
207
AKT1
P31749
6416
MAP2K4
P45985
physical association
11707464
207
AKT1
P31749
6416
MAP2K4
P45985
direct interaction
11707464
207
AKT1
P31749
7015
TERT
O14746
physical association
15843522
207
AKT1
P31749
7248
TSC1
Q92574
physical association
12167664
207
AKT1
P31749
7249
TSC2
P49815
physical association
12167664
207
AKT1
P31749
7249
TSC2
P49815
direct interaction
12167664
207
AKT1
P31749
367
AR
P10275
physical association
11404460
207
AKT1
P31749
367
AR
P10275
direct interaction
11404460
207
AKT1
P31749
4771
NF2
P35240
physical association
17891137
207
AKT1
P31749
4771
NF2
P35240
direct interaction
17891137
207
AKT1
P31749
2932
GSK3B
P49841
direct interaction
16123141
207
AKT1
P31749
2099
ESR1
P03372
direct interaction
11139588
207
AKT1
P31749
2597
GAPDH
P04406
physical association
16027165
207
AKT1
P31749
7534
YWHAZ
P63104
physical association
16027165
207
AKT1
P31749
7531
YWHAE
P62258
physical association
16027165
207
AKT1
P31749
2932
GSK3B
P49841
direct interaction
15470047
207
AKT1
P31749
1655
DDX5
P17844
physical association
20856200
207
AKT1
P31749
4193
MDM2
Q00987
physical association
21930127
207
AKT1
P31749
2065
ERBB3
P21860
physical association
21930127
207
AKT1
P31749
2932
GSK3B
P49841
direct interaction
19995607
207
AKT1
P31749
2931
GSK3A
P49840
direct interaction
19995607
207
AKT1
P31749
572
BAD
Q92934
direct interaction
11994280
207
AKT1
P31749
572
BAD
Q92934
direct interaction
11500364
207
AKT1
P31749
2475
MTOR
P42345
direct interaction
10910062
207
AKT1
P31749
2475
MTOR
P42345
direct interaction
14970221
207
AKT1
P31749
2932
GSK3B
P49841
direct interaction
16009706
207
AKT1
P31749
2931
GSK3A
P49840
direct interaction
17505062
207
AKT1
P31749
4851
NOTCH1
P46531
direct interaction
18440314
207
AKT1
P31749
60
ACTB
P60709
physical association
20856200
207
AKT1
P31749
4193
MDM2
Q00987
physical association
20856200
207
AKT1
P31749
2932
GSK3B
P49841
physical association
20856200
207
AKT1
P31749
1655
DDX5
P17844
physical association
20856200
207
AKT1
P31749
2931
GSK3A
P49840
direct interaction
14645548
207
AKT1
P31749
2932
GSK3B
P49841
direct interaction
14645548
207
AKT1
P31749
2033
EP300
Q09472
physical association
18182168
207
AKT1
P31749
5894
RAF1
P04049
direct interaction
10576742
207
AKT1
P31749
9846
GAB2
Q9UQC2
direct interaction
11782427
207
AKT1
P31749
7534
YWHAZ
P63104
direct interaction
11956222
207
AKT1
P31749
7534
YWHAZ
P63104
physical association
11956222
207
AKT1
P31749
7534
YWHAZ
P63104
direct interaction
11956222
208
AKT2
P31751
1111
CHEK1
O14757
physical association
17962807
208
AKT2
P31751
2099
ESR1
P03372
direct interaction
11507039
10000
AKT3
Q9Y243
5590
PRKCZ
Q05513
direct interaction
12162751
10000
AKT3
Q9Y243
5590
PRKCZ
Q05513
physical association
12162751
239
ALOX12
P18054
3691
ITGB4
P16144
direct interaction
10727209
51433
ANAPC5
Q9UJX4
891
CCNB1
P14635
direct interaction
22193957
51433
ANAPC5
Q9UJX4
891
CCNB1
P14635
direct interaction
20080579
310
ANXA7
P20073
7157
TP53
P04637
direct interaction
21900206
310
ANXA7
P20073
3032
HADHB
P55084
direct interaction
21900206
310
ANXA7
P20073
2597
GAPDH
P04406
direct interaction
21900206
310
ANXA7
P20073
1019
CDK4
P11802
direct interaction
21900206
310
ANXA7
P20073
6117
RPA1
P27694
direct interaction
21900206
310
ANXA7
P20073
2244
FGB
P02675
direct interaction
21900206
310
ANXA7
P20073
60
ACTB
P60709
direct interaction
21900206
310
ANXA7
P20073
2
A2M
P01023
direct interaction
21900206
310
ANXA7
P20073
1508
CTSB
P07858
direct interaction
21900206
310
ANXA7
P20073
506
ATP5B
P06576
direct interaction
21900206
1173
AP2M1
Q96CW1
31
ACACA
Q13085
physical association
19380743
1173
AP2M1
Q96CW1
1173
AP2M1
Q96CW1
physical association
19380743
1173
AP2M1
Q96CW1
60
ACTB
P60709
physical association
19380743
1173
AP2M1
Q96CW1
3853
KRT6A
P02538
physical association
19380743
1173
AP2M1
Q96CW1
3872
KRT17
Q04695
physical association
19380743
1173
AP2M1
Q96CW1
2597
GAPDH
P04406
physical association
19380743
1173
AP2M1
Q96CW1
23603
CORO1C
Q9ULV4
physical association
19380743
1173
AP2M1
Q96CW1
2194
FASN
P49327
physical association
19380743
324
APC
P25054
3872
KRT17
Q04695
direct interaction
20936779
324
APC
P25054
310
ANXA7
P20073
direct interaction
20936779
324
APC
P25054
87
ACTN1
P12814
direct interaction
20936779
324
APC
P25054
3909
LAMA3
Q16787
direct interaction
20936779
324
APC
P25054
3880
KRT19
P08727
direct interaction
20936779
324
APC
P25054
4629
MYH11
P35749
direct interaction
20936779
324
APC
P25054
5111
PCNA
P12004
physical association
21664290
324
APC
P25054
6118
RPA2
P15927
physical association
21664290
324
APC
P25054
1499
CTNNB1
P35222
physical association
21664290
324
APC
P25054
1499
CTNNB1
P35222
direct interaction
8259519
324
APC
P25054
1499
CTNNB1
P35222
physical association
8259519
324
APC
P25054
324
APC
P25054
direct interaction
12070164
324
APC
P25054
324
APC
P25054
direct interaction
8389242
324
APC
P25054
1499
CTNNB1
P35222
physical association
11972058
324
APC
P25054
1499
CTNNB1
P35222
direct interaction
12628243
324
APC
P25054
7020
TFAP2A
P05549
physical association
15331612
324
APC
P25054
324
APC
P25054
physical association
8389242
324
APC
P25054
1499
CTNNB1
P35222
direct interaction
16510874
324
APC
P25054
1499
CTNNB1
P35222
physical association
11251183
324
APC
P25054
1499
CTNNB1
P35222
physical association
15355978
324
APC
P25054
1499
CTNNB1
P35222
physical association
9286858
335
APOA1
P02647
338
APOB
P04114
physical association
19164805
335
APOA1
P02647
19
ABCA1
O95477
direct interaction
12084722
335
APOA1
P02647
335
APOA1
P02647
association
9356442
338
APOB
P04114
338
APOB
P04114
physical association
19164805
338
APOB
P04114
335
APOA1
P02647
physical association
19164805
360
AQP3
Q92482
857
CAV1
Q03135
physical association
14675200
367
AR
P10275
367
AR
P10275
direct interaction
12682292
367
AR
P10275
5894
RAF1
P04049
association
8349631
367
AR
P10275
1499
CTNNB1
P35222
physical association
11916967
367
AR
P10275
7329
UBE2I
P63279
direct interaction
10383460
367
AR
P10275
7329
UBE2I
P63279
additive genetic interaction defined by inequality
10383460
367
AR
P10275
1869
E2F1
Q01094
physical association
22508987
367
AR
P10275
6925
TCF4
P15884
direct interaction
12799378
367
AR
P10275
9759
HDAC4
P56524
direct interaction
21242980
367
AR
P10275
9759
HDAC4
P56524
physical association
21242980
367
AR
P10275
4088
SMAD3
P84022
physical association
11707452
367
AR
P10275
367
AR
P10275
direct interaction
15062556
367
AR
P10275
6774
STAT3
P40763
direct interaction
11751884
367
AR
P10275
6774
STAT3
P40763
physical association
11322786
367
AR
P10275
367
AR
P10275
direct interaction
15525515
367
AR
P10275
367
AR
P10275
association
15525515
367
AR
P10275
1499
CTNNB1
P35222
physical association
12799378
367
AR
P10275
1499
CTNNB1
P35222
direct interaction
12799378
367
AR
P10275
7157
TP53
P04637
suppressive genetic interaction defined by inequality
11504717
367
AR
P10275
3316
HSPB2
Q16082
physical association
17974989
367
AR
P10275
4193
MDM2
Q00987
physical association
17974989
367
AR
P10275
3725
JUN
P05412
physical association
9211894
367
AR
P10275
1499
CTNNB1
P35222
direct interaction
15256534
367
AR
P10275
7520
XRCC5
P13010
direct interaction
15640154
367
AR
P10275
367
AR
P10275
direct interaction
11504717
367
AR
P10275
4088
SMAD3
P84022
direct interaction
11280774
367
AR
P10275
1499
CTNNB1
P35222
direct interaction
14593076
367
AR
P10275
367
AR
P10275
direct interaction
15256534
367
AR
P10275
2033
EP300
Q09472
physical association
18487222
367
AR
P10275
6925
TCF4
P15884
physical association
12799378
367
AR
P10275
6714
SRC
P12931
direct interaction
15027889
367
AR
P10275
4088
SMAD3
P84022
physical association
11280774
367
AR
P10275
4088
SMAD3
P84022
direct interaction
11280774
367
AR
P10275
1956
EGFR
P00533
colocalization
15305378
367
AR
P10275
1956
EGFR
P00533
colocalization
15288768
367
AR
P10275
23118
TAB2
Q9NYJ8
physical association
16469706
367
AR
P10275
1499
CTNNB1
P35222
physical association
12944908
367
AR
P10275
4089
SMAD4
Q13485
direct interaction
12226080
367
AR
P10275
4088
SMAD3
P84022
direct interaction
12226080
367
AR
P10275
4089
SMAD4
Q13485
physical association
12226080
367
AR
P10275
4088
SMAD3
P84022
physical association
12226080
367
AR
P10275
51497
NELFCD
Q8IXH7
direct interaction
20069563
367
AR
P10275
51497
NELFCD
Q8IXH7
physical association
20069563
367
AR
P10275
5469
MED1
Q15648
direct interaction
12218053
367
AR
P10275
23411
SIRT1
Q96EB6
physical association
16923962
367
AR
P10275
4193
MDM2
Q00987
physical association
15640443
367
AR
P10275
6714
SRC
P12931
direct interaction
15062576
367
AR
P10275
4193
MDM2
Q00987
direct interaction
21157430
367
AR
P10275
2068
ERCC2
P18074
direct interaction
21157430
367
AR
P10275
9759
HDAC4
P56524
direct interaction
12943985
367
AR
P10275
3146
HMGB1
P09429
direct interaction
9671457
369
ARAF
P10398
51497
NELFCD
Q8IXH7
direct interaction
12620389
369
ARAF
P10398
7534
YWHAZ
P63104
direct interaction
20936779
369
ARAF
P10398
7531
YWHAE
P62258
direct interaction
20936779
369
ARAF
P10398
51497
NELFCD
Q8IXH7
direct interaction
11952167
369
ARAF
P10398
51497
NELFCD
Q8IXH7
direct interaction
11952167
369
ARAF
P10398
5295
PIK3R1
P27986
direct interaction
11812000
8289
ARID1A
O14497
6714
SRC
P12931
direct interaction
17363140
23204
ARL6IP1
Q15041
55294
FBXW7
Q969H0
direct interaction
16169070
23204
ARL6IP1
Q15041
2222
FDFT1
P37268
direct interaction
16169070
92714
ARRDC1
Q8N5I2
83737
ITCH
Q96J02
direct interaction
21191027
472
ATM
Q13315
7158
TP53BP1
Q12888
direct interaction
12697768
472
ATM
Q13315
7158
TP53BP1
Q12888
direct interaction
18996087
472
ATM
Q13315
25
ABL1
P00519
direct interaction
9168117
472
ATM
Q13315
7157
TP53
P04637
direct interaction
17409407
472
ATM
Q13315
25
ABL1
P00519
direct interaction
17409407
472
ATM
Q13315
7157
TP53
P04637
direct interaction
15159397
472
ATM
Q13315
7157
TP53
P04637
direct interaction
9843217
472
ATM
Q13315
7157
TP53
P04637
direct interaction
15632067
472
ATM
Q13315
7157
TP53
P04637
direct interaction
9843217
472
ATM
Q13315
4683
NBN
O60934
direct interaction
10608806
472
ATM
Q13315
4361
MRE11A
P49959
direct interaction
10608806
472
ATM
Q13315
7157
TP53
P04637
direct interaction
10608806
472
ATM
Q13315
472
ATM
Q13315
direct interaction
10608806
472
ATM
Q13315
1978
EIF4EBP1
Q13541
direct interaction
10608806
472
ATM
Q13315
1111
CHEK1
O14757
direct interaction
10608806
472
ATM
Q13315
7158
TP53BP1
Q12888
direct interaction
12447390
472
ATM
Q13315
25
ABL1
P00519
physical association
10212258
472
ATM
Q13315
4193
MDM2
Q00987
direct interaction
22976441
472
ATM
Q13315
675
BRCA2
P51587
direct interaction
15199141
472
ATM
Q13315
7157
TP53
P04637
additive genetic interaction defined by inequality
9135004
472
ATM
Q13315
11200
CHEK2
O96017
direct interaction
10973490
472
ATM
Q13315
4683
NBN
O60934
physical association
15758953
472
ATM
Q13315
4361
MRE11A
P49959
physical association
15758953
472
ATM
Q13315
4683
NBN
O60934
direct interaction
15758953
472
ATM
Q13315
25
ABL1
P00519
physical association
11375976
472
ATM
Q13315
5888
RAD51
Q06609
physical association
10212258
472
ATM
Q13315
7157
TP53
P04637
direct interaction
19965871
472
ATM
Q13315
7428
VHL
P40337
physical association
16678111
472
ATM
Q13315
1432
MAPK14
Q16539
physical association
17172861
472
ATM
Q13315
7157
TP53
P04637
direct interaction
11459832
472
ATM
Q13315
1869
E2F1
Q01094
direct interaction
11459832
472
ATM
Q13315
472
ATM
Q13315
physical association
20360068
472
ATM
Q13315
4683
NBN
O60934
physical association
22464731
472
ATM
Q13315
2309
FOXO3
O43524
physical association
18344987
472
ATM
Q13315
25
ABL1
P00519
physical association
20798688
472
ATM
Q13315
11200
CHEK2
O96017
direct interaction
15064416
472
ATM
Q13315
11200
CHEK2
O96017
direct interaction
15064416
472
ATM
Q13315
7157
TP53
P04637
direct interaction
15064416
472
ATM
Q13315
7157
TP53
P04637
direct interaction
15064416
472
ATM
Q13315
5469
MED1
Q15648
physical association
17478428
472
ATM
Q13315
7157
TP53
P04637
direct interaction
21383020
6310
ATXN1
P54253
31
ACACA
Q13085
direct interaction
16713569
6310
ATXN1
P54253
6310
ATXN1
P54253
direct interaction
16713569
6310
ATXN1
P54253
7447
VSNL1
P62760
direct interaction
16713569
6310
ATXN1
P54253
7329
UBE2I
P63279
direct interaction
16713569
6310
ATXN1
P54253
3691
ITGB4
P16144
direct interaction
16713569
6310
ATXN1
P54253
3303
HSPA1A
P0DMV8
direct interaction
16713569
6310
ATXN1
P54253
3164
NR4A1
P22736
direct interaction
16713569
6310
ATXN1
P54253
30815
ST6GALNAC6
Q969X2
direct interaction
16713569
6310
ATXN1
P54253
8125
ANP32A
P39687
direct interaction
9353121
25814
ATXN10
Q9UBB4
19
ABCA1
O95477
direct interaction
16498633
25814
ATXN10
Q9UBB4
2335
FN1
P02751
direct interaction
16498633
6790
AURKA
O14965
2932
GSK3B
P49841
physical association
22513362
6790
AURKA
O14965
55294
FBXW7
Q969H0
physical association
22513362
6790
AURKA
O14965
6790
AURKA
O14965
physical association
20360068
6790
AURKA
O14965
1029
CDKN2A
Q8N726
physical association
17353931
6790
AURKA
O14965
7157
TP53
P04637
physical association
14702041
6790
AURKA
O14965
7157
TP53
P04637
direct interaction
14702041
6790
AURKA
O14965
5347
PLK1
P53350
physical association
18773538
6790
AURKA
O14965
7334
UBE2N
P61088
direct interaction
12881723
6790
AURKA
O14965
7020
TFAP2A
P05549
physical association
21829699
6790
AURKA
O14965
7157
TP53
P04637
physical association
12198151
6790
AURKA
O14965
7157
TP53
P04637
suppressive genetic interaction defined by inequality
12198151
558
AXL
P30530
3932
LCK
P06239
direct interaction
9178760
558
AXL
P30530
6714
SRC
P12931
direct interaction
9178760
558
AXL
P30530
5295
PIK3R1
P27986
direct interaction
9178760
572
BAD
Q92934
581
BAX
Q07812
physical association
17274640
572
BAD
Q92934
598
BCL2L1
Q07817
physical association
9824152
572
BAD
Q92934
598
BCL2L1
Q07817
physical association
15705582
572
BAD
Q92934
7531
YWHAE
P62258
direct interaction
9369453
572
BAD
Q92934
7529
YWHAB
P31946
direct interaction
9369453
572
BAD
Q92934
596
BCL2
P10415
direct interaction
7834748
572
BAD
Q92934
598
BCL2L1
Q07817
direct interaction
7834748
572
BAD
Q92934
596
BCL2
P10415
physical association
7834748
572
BAD
Q92934
598
BCL2L1
Q07817
physical association
7834748
572
BAD
Q92934
7529
YWHAB
P31946
direct interaction
21900206
572
BAD
Q92934
598
BCL2L1
Q07817
direct interaction
10620799
572
BAD
Q92934
598
BCL2L1
Q07817
physical association
11494146
572
BAD
Q92934
4170
MCL1
Q07820
direct interaction
11483855
572
BAD
Q92934
598
BCL2L1
Q07817
direct interaction
11077446
572
BAD
Q92934
598
BCL2L1
Q07817
physical association
15694340
572
BAD
Q92934
596
BCL2
P10415
physical association
15694340
572
BAD
Q92934
598
BCL2L1
Q07817
direct interaction
11206074
578
BAK1
Q16611
598
BCL2L1
Q07817
direct interaction
11175750
578
BAK1
Q16611
578
BAK1
Q16611
physical association
15077116
578
BAK1
Q16611
581
BAX
Q07812
physical association
11571294
578
BAK1
Q16611
598
BCL2L1
Q07817
direct interaction
16189514
578
BAK1
Q16611
598
BCL2L1
Q07817
physical association
16189514
578
BAK1
Q16611
4170
MCL1
Q07820
direct interaction
10837489
8314
BAP1
Q92560
3303
HSPA1A
P0DMV8
association
20805357
581
BAX
Q07812
598
BCL2L1
Q07817
physical association
12853473
581
BAX
Q07812
598
BCL2L1
Q07817
physical association
22072718
581
BAX
Q07812
596
BCL2
P10415
physical association
10716992
581
BAX
Q07812
596
BCL2
P10415
physical association
20865015
581
BAX
Q07812
596
BCL2
P10415
physical association
8358790
581
BAX
Q07812
596
BCL2
P10415
physical association
21778226
581
BAX
Q07812
7520
XRCC5
P13010
physical association
19177010
581
BAX
Q07812
596
BCL2
P10415
direct interaction
10620799
581
BAX
Q07812
840
CASP7
P55210
colocalization
15254227
581
BAX
Q07812
836
CASP3
P42574
colocalization
15254227
581
BAX
Q07812
581
BAX
Q07812
direct interaction
21712378
581
BAX
Q07812
581
BAX
Q07812
physical association
21712378
581
BAX
Q07812
7157
TP53
P04637
physical association
21712378
581
BAX
Q07812
578
BAK1
Q16611
physical association
21712378
581
BAX
Q07812
581
BAX
Q07812
direct interaction
11161816
581
BAX
Q07812
4170
MCL1
Q07820
direct interaction
10837489
596
BCL2
P10415
983
CDK1
P06493
physical association
11326318
596
BCL2
P10415
8678
BECN1
Q14457
direct interaction
9765397
596
BCL2
P10415
7157
TP53
P04637
physical association
21597459
596
BCL2
P10415
581
BAX
Q07812
physical association
15231068
596
BCL2
P10415
5894
RAF1
P04049
physical association
8929532
596
BCL2
P10415
5894
RAF1
P04049
direct interaction
8929532
596
BCL2
P10415
581
BAX
Q07812
physical association
22262057
596
BCL2
P10415
3091
HIF1A
Q16665
physical association
20668552
596
BCL2
P10415
581
BAX
Q07812
physical association
20865015
596
BCL2
P10415
10018
BCL2L11
O43521
physical association
19805519
596
BCL2
P10415
8678
BECN1
Q14457
physical association
20010695
596
BCL2
P10415
8678
BECN1
Q14457
physical association
20889974
596
BCL2
P10415
4609
MYC
P01106
physical association
15210690
596
BCL2
P10415
983
CDK1
P06493
physical association
11774038
596
BCL2
P10415
4609
MYC
P01106
colocalization
15210690
596
BCL2
P10415
8678
BECN1
Q14457
physical association
21543763
596
BCL2
P10415
581
BAX
Q07812
direct interaction
14980220
596
BCL2
P10415
3164
NR4A1
P22736
physical association
14980220
596
BCL2
P10415
581
BAX
Q07812
physical association
14980220
596
BCL2
P10415
578
BAK1
Q16611
physical association
14980220
596
BCL2
P10415
598
BCL2L1
Q07817
physical association
14980220
596
BCL2
P10415
3164
NR4A1
P22736
direct interaction
14980220
596
BCL2
P10415
3164
NR4A1
P22736
direct interaction
14980220
596
BCL2
P10415
8678
BECN1
Q14457
direct interaction
9765397
596
BCL2
P10415
3164
NR4A1
P22736
physical association
16434970
596
BCL2
P10415
3667
IRS1
P35568
physical association
10679027
596
BCL2
P10415
8678
BECN1
Q14457
physical association
21358617
596
BCL2
P10415
637
BID
P55957
direct interaction
15694340
596
BCL2
P10415
578
BAK1
Q16611
direct interaction
11728179
596
BCL2
P10415
10018
BCL2L11
O43521
direct interaction
9430630
596
BCL2
P10415
10018
BCL2L11
O43521
physical association
9430630
598
BCL2L1
Q07817
581
BAX
Q07812
physical association
22072718
598
BCL2L1
Q07817
581
BAX
Q07812
physical association
9824152
598
BCL2L1
Q07817
572
BAD
Q92934
physical association
15705582
598
BCL2L1
Q07817
578
BAK1
Q16611
direct interaction
12137781
598
BCL2L1
Q07817
11315
PARK7
Q99497
direct interaction
21852238
598
BCL2L1
Q07817
11315
PARK7
Q99497
physical association
21852238
598
BCL2L1
Q07817
581
BAX
Q07812
direct interaction
21852238
598
BCL2L1
Q07817
581
BAX
Q07812
physical association
21852238
598
BCL2L1
Q07817
572
BAD
Q92934
physical association
12115603
598
BCL2L1
Q07817
578
BAK1
Q16611
physical association
15901672
598
BCL2L1
Q07817
578
BAK1
Q16611
direct interaction
15901672
598
BCL2L1
Q07817
572
BAD
Q92934
direct interaction
12137781
598
BCL2L1
Q07817
596
BCL2
P10415
direct interaction
12137781
598
BCL2L1
Q07817
581
BAX
Q07812
direct interaction
12137781
598
BCL2L1
Q07817
578
BAK1
Q16611
direct interaction
14596824
598
BCL2L1
Q07817
10018
BCL2L11
O43521
direct interaction
14596824
598
BCL2L1
Q07817
8678
BECN1
Q14457
direct interaction
9765397
598
BCL2L1
Q07817
10018
BCL2L11
O43521
physical association
16260615
598
BCL2L1
Q07817
7157
TP53
P04637
direct interaction
21900206
598
BCL2L1
Q07817
2203
FBP1
P09467
direct interaction
21900206
598
BCL2L1
Q07817
60
ACTB
P60709
direct interaction
21900206
598
BCL2L1
Q07817
637
BID
P55957
direct interaction
15694340
598
BCL2L1
Q07817
572
BAD
Q92934
direct interaction
9389483
10018
BCL2L11
O43521
596
BCL2
P10415
physical association
19805519
10018
BCL2L11
O43521
23321
TRIM2
Q9C040
direct interaction
21478148
10018
BCL2L11
O43521
596
BCL2
P10415
direct interaction
9731710
10018
BCL2L11
O43521
4170
MCL1
Q07820
direct interaction
9731710
10018
BCL2L11
O43521
4170
MCL1
Q07820
physical association
19150432
10018
BCL2L11
O43521
598
BCL2L1
Q07817
direct interaction
9731710
10018
BCL2L11
O43521
7428
VHL
P40337
physical association
19305426
10018
BCL2L11
O43521
4170
MCL1
Q07820
direct interaction
10837489
10018
BCL2L11
O43521
4170
MCL1
Q07820
physical association
15694340
10018
BCL2L11
O43521
598
BCL2L1
Q07817
physical association
15694340
10018
BCL2L11
O43521
596
BCL2
P10415
physical association
15694340
10018
BCL2L11
O43521
598
BCL2L1
Q07817
physical association
9430630
8678
BECN1
Q14457
7128
TNFAIP3
P21580
physical association
20501938
8678
BECN1
Q14457
8678
BECN1
Q14457
physical association
20501938
8678
BECN1
Q14457
7248
TSC1
Q92574
physical association
20562859
8678
BECN1
Q14457
23118
TAB2
Q9NYJ8
physical association
21976705
8678
BECN1
Q14457
83737
ITCH
Q96J02
direct interaction
21936852
79365
BHLHE41
Q9C0J9
79365
BHLHE41
Q9C0J9
direct interaction
17487425
79365
BHLHE41
Q9C0J9
1051
CEBPB
P17676
physical association
19029947
79365
BHLHE41
Q9C0J9
79365
BHLHE41
Q9C0J9
physical association
22801492
79365
BHLHE41
Q9C0J9
3091
HIF1A
Q16665
physical association
22801492
637
BID
P55957
637
BID
P55957
physical association
11805084
637
BID
P55957
6117
RPA1
P27694
direct interaction
21859891
637
BID
P55957
6117
RPA1
P27694
physical association
21859891
637
BID
P55957
6118
RPA2
P15927
physical association
21859891
637
BID
P55957
596
BCL2
P10415
direct interaction
15520201
637
BID
P55957
5599
MAPK8
P45983
association
15659383
637
BID
P55957
2597
GAPDH
P04406
direct interaction
21900206
329
BIRC2
Q13490
329
BIRC2
Q13490
direct interaction
21048196
329
BIRC2
Q13490
329
BIRC2
Q13490
direct interaction
21113135
329
BIRC2
Q13490
329
BIRC2
Q13490
direct interaction
21113135
329
BIRC2
Q13490
836
CASP3
P42574
direct interaction
9384571
329
BIRC2
Q13490
840
CASP7
P55210
direct interaction
9384571
329
BIRC2
Q13490
56616
DIABLO
Q9NR28
physical association
12865429
329
BIRC2
Q13490
56616
DIABLO
Q9NR28
physical association
16282325
329
BIRC2
Q13490
329
BIRC2
Q13490
direct interaction
21331077
329
BIRC2
Q13490
329
BIRC2
Q13490
direct interaction
18022362
329
BIRC2
Q13490
840
CASP7
P55210
physical association
15580265
329
BIRC2
Q13490
11047
ADRM1
Q16186
physical association
18939944
329
BIRC2
Q13490
5894
RAF1
P04049
direct interaction
19011619
329
BIRC2
Q13490
840
CASP7
P55210
physical association
16339151
329
BIRC2
Q13490
56616
DIABLO
Q9NR28
direct interaction
14960576
329
BIRC2
Q13490
329
BIRC2
Q13490
association
22021857
329
BIRC2
Q13490
836
CASP3
P42574
physical association
17069460
329
BIRC2
Q13490
329
BIRC2
Q13490
direct interaction
22021857
329
BIRC2
Q13490
329
BIRC2
Q13490
direct interaction
22493164
329
BIRC2
Q13490
329
BIRC2
Q13490
association
21549626
329
BIRC2
Q13490
56616
DIABLO
Q9NR28
association
19153467
329
BIRC2
Q13490
56616
DIABLO
Q9NR28
direct interaction
19153467
329
BIRC2
Q13490
332
BIRC5
O15392
direct interaction
15665297
329
BIRC2
Q13490
329
BIRC2
Q13490
direct interaction
19810754
329
BIRC2
Q13490
329
BIRC2
Q13490
direct interaction
11907583
329
BIRC2
Q13490
332
BIRC5
O15392
direct interaction
15218035
329
BIRC2
Q13490
56616
DIABLO
Q9NR28
physical association
12525502
329
BIRC2
Q13490
56616
DIABLO
Q9NR28
direct interaction
12525502
329
BIRC2
Q13490
329
BIRC2
Q13490
direct interaction
21393245
329
BIRC2
Q13490
329
BIRC2
Q13490
direct interaction
21393245
329
BIRC2
Q13490
836
CASP3
P42574
direct interaction
19258326
329
BIRC2
Q13490
840
CASP7
P55210
direct interaction
19258326
329
BIRC2
Q13490
840
CASP7
P55210
direct interaction
19258326
329
BIRC2
Q13490
836
CASP3
P42574
direct interaction
19258326
329
BIRC2
Q13490
56616
DIABLO
Q9NR28
physical association
19506082
329
BIRC2
Q13490
1869
E2F1
Q01094
physical association
21653699
332
BIRC5
O15392
332
BIRC5
O15392
association
10876248
332
BIRC5
O15392
836
CASP3
P42574
direct interaction
9850056
332
BIRC5
O15392
840
CASP7
P55210
direct interaction
9850056
332
BIRC5
O15392
1017
CDK2
P24941
physical association
11069302
332
BIRC5
O15392
332
BIRC5
O15392
direct interaction
17099693
332
BIRC5
O15392
332
BIRC5
O15392
association
10949039
332
BIRC5
O15392
329
BIRC2
Q13490
physical association
15665297
332
BIRC5
O15392
840
CASP7
P55210
direct interaction
11170436
332
BIRC5
O15392
836
CASP3
P42574
direct interaction
11170436
332
BIRC5
O15392
836
CASP3
P42574
direct interaction
11170436
332
BIRC5
O15392
332
BIRC5
O15392
direct interaction
11170436
332
BIRC5
O15392
840
CASP7
P55210
direct interaction
11170436
332
BIRC5
O15392
1019
CDK4
P11802
physical association
10713676
673
BRAF
P15056
5604
MAP2K1
Q02750
physical association
18332145
673
BRAF
P15056
5894
RAF1
P04049
physical association
18332145
673
BRAF
P15056
207
AKT1
P31749
physical association
10869359
673
BRAF
P15056
5604
MAP2K1
Q02750
direct interaction
20212043
673
BRAF
P15056
7529
YWHAB
P31946
physical association
10931830
673
BRAF
P15056
5894
RAF1
P04049
physical association
11325826
675
BRCA2
P51587
5888
RAD51
Q06609
direct interaction
9126738
675
BRCA2
P51587
5888
RAD51
Q06609
physical association
9774970
675
BRCA2
P51587
5888
RAD51
Q06609
colocalization
14580352
675
BRCA2
P51587
5888
RAD51
Q06609
physical association
14580352
675
BRCA2
P51587
5888
RAD51
Q06609
physical association
12815053
675
BRCA2
P51587
5888
RAD51
Q06609
physical association
14636569
675
BRCA2
P51587
5888
RAD51
Q06609
physical association
20729859
675
BRCA2
P51587
5888
RAD51
Q06609
association
14636569
675
BRCA2
P51587
5888
RAD51
Q06609
physical association
14636569
675
BRCA2
P51587
5888
RAD51
Q06609
physical association
11477095
675
BRCA2
P51587
5888
RAD51
Q06609
physical association
9560268
675
BRCA2
P51587
5888
RAD51
Q06609
direct interaction
9560268
675
BRCA2
P51587
5888
RAD51
Q06609
direct interaction
9560268
675
BRCA2
P51587
5888
RAD51
Q06609
direct interaction
21670257
675
BRCA2
P51587
5888
RAD51
Q06609
colocalization
15065660
675
BRCA2
P51587
5888
RAD51
Q06609
direct interaction
12442171
675
BRCA2
P51587
5888
RAD51
Q06609
physical association
16793542
675
BRCA2
P51587
5888
RAD51
Q06609
physical association
16793542
675
BRCA2
P51587
7157
TP53
P04637
physical association
14636569
675
BRCA2
P51587
7157
TP53
P04637
association
14636569
675
BRCA2
P51587
7157
TP53
P04637
physical association
14636569
675
BRCA2
P51587
5888
RAD51
Q06609
direct interaction
9405383
675
BRCA2
P51587
5888
RAD51
Q06609
direct interaction
9405383
675
BRCA2
P51587
5888
RAD51
Q06609
direct interaction
9523196
675
BRCA2
P51587
5888
RAD51
Q06609
physical association
9523196
675
BRCA2
P51587
5888
RAD51
Q06609
physical association
9811893
675
BRCA2
P51587
4088
SMAD3
P84022
physical association
12165866
675
BRCA2
P51587
4088
SMAD3
P84022
direct interaction
12165866
675
BRCA2
P51587
6117
RPA1
P27694
physical association
12527904
675
BRCA2
P51587
6117
RPA1
P27694
direct interaction
12527904
675
BRCA2
P51587
5888
RAD51
Q06609
physical association
11313963
675
BRCA2
P51587
5888
RAD51
Q06609
colocalization
21076401
675
BRCA2
P51587
5888
RAD51
Q06609
physical association
16914443
675
BRCA2
P51587
5888
RAD51
Q06609
physical association
15671039
675
BRCA2
P51587
6776
STAT5A
P42229
physical association
12459499
682
BSG
P35613
25814
ATXN10
Q9UBB4
physical association
17353931
682
BSG
P35613
6566
SLC16A1
P53985
physical association
10921872
682
BSG
P35613
9260
PDLIM7
Q9NR12
direct interaction
16189514
708
C1QBP
Q07021
8683
SRSF9
Q13242
direct interaction
10022843
708
C1QBP
Q07021
6426
SRSF1
Q07955
direct interaction
10022843
708
C1QBP
Q07021
5590
PRKCZ
Q05513
direct interaction
10831594
708
C1QBP
Q07021
5578
PRKCA
P17252
physical association
10831594
708
C1QBP
Q07021
5578
PRKCA
P17252
direct interaction
10831594
708
C1QBP
Q07021
5580
PRKCD
Q05655
direct interaction
10831594
708
C1QBP
Q07021
5580
PRKCD
Q05655
physical association
10831594
708
C1QBP
Q07021
5590
PRKCZ
Q05513
physical association
10831594
768
CA9
Q16790
999
CDH1
P12830
physical association
14567991
768
CA9
Q16790
1499
CTNNB1
P35222
physical association
14567991
775
CACNA1C
Q13936
9759
HDAC4
P56524
direct interaction
21464227
836
CASP3
P42574
7187
TRAF3
Q13114
direct interaction
11261798
836
CASP3
P42574
596
BCL2
P10415
direct interaction
11752215
836
CASP3
P42574
4170
MCL1
Q07820
direct interaction
15637055
836
CASP3
P42574
329
BIRC2
Q13490
direct interaction
11106668
836
CASP3
P42574
7187
TRAF3
Q13114
direct interaction
11098060
836
CASP3
P42574
4193
MDM2
Q00987
direct interaction
9278461
836
CASP3
P42574
3329
HSPD1
P10809
physical association
10205159
836
CASP3
P42574
3329
HSPD1
P10809
physical association
10205158
836
CASP3
P42574
637
BID
P55957
direct interaction
11399776
836
CASP3
P42574
836
CASP3
P42574
association
11257232
857
CAV1
Q03135
4843
NOS2
P35228
direct interaction
11114180
857
CAV1
Q03135
4843
NOS2
P35228
colocalization
11114180
857
CAV1
Q03135
6714
SRC
P12931
direct interaction
8910575
857
CAV1
Q03135
367
AR
P10275
physical association
11278309
857
CAV1
Q03135
367
AR
P10275
direct interaction
11278309
857
CAV1
Q03135
367
AR
P10275
direct interaction
11278309
857
CAV1
Q03135
5595
MAPK3
P27361
physical association
12388423
857
CAV1
Q03135
5594
MAPK1
P28482
physical association
12388423
857
CAV1
Q03135
1956
EGFR
P00533
physical association
12388423
857
CAV1
Q03135
5743
PTGS2
P35354
physical association
19960513
857
CAV1
Q03135
5743
PTGS2
P35354
physical association
11432874
857
CAV1
Q03135
360
AQP3
Q92482
physical association
14675200
857
CAV1
Q03135
2697
GJA1
P17302
direct interaction
11980479
865
CBFB
Q13951
861
RUNX1
Q01196
physical association
20195544
891
CCNB1
P14635
5111
PCNA
P12004
physical association
7903056
891
CCNB1
P14635
983
CDK1
P06493
physical association
2570636
891
CCNB1
P14635
6117
RPA1
P27694
direct interaction
8397207
891
CCNB1
P14635
891
CCNB1
P14635
direct interaction
8397207
891
CCNB1
P14635
1017
CDK2
P24941
physical association
9891079
891
CCNB1
P14635
983
CDK1
P06493
physical association
9891079
891
CCNB1
P14635
1017
CDK2
P24941
physical association
20733051
891
CCNB1
P14635
983
CDK1
P06493
physical association
16784539
891
CCNB1
P14635
1017
CDK2
P24941
physical association
18471975
891
CCNB1
P14635
983
CDK1
P06493
direct interaction
9247342
891
CCNB1
P14635
6117
RPA1
P27694
direct interaction
8397206
891
CCNB1
P14635
1026
CDKN1A
P38936
physical association
17679094
891
CCNB1
P14635
983
CDK1
P06493
physical association
17679094
891
CCNB1
P14635
983
CDK1
P06493
physical association
16159883
891
CCNB1
P14635
983
CDK1
P06493
physical association
20733055
891
CCNB1
P14635
983
CDK1
P06493
physical association
17431037
891
CCNB1
P14635
983
CDK1
P06493
physical association
20956543
891
CCNB1
P14635
2305
FOXM1
Q08050
physical association
15024056
891
CCNB1
P14635
983
CDK1
P06493
physical association
20228808
595
CCND1
P24385
5925
RB1
P06400
direct interaction
9178893
595
CCND1
P24385
1019
CDK4
P11802
physical association
9178893
595
CCND1
P24385
1017
CDK2
P24941
physical association
9178893
595
CCND1
P24385
5925
RB1
P06400
direct interaction
11126356
595
CCND1
P24385
1019
CDK4
P11802
physical association
9837900
595
CCND1
P24385
5925
RB1
P06400
direct interaction
8647086
595
CCND1
P24385
5111
PCNA
P12004
direct interaction
7908906
595
CCND1
P24385
5925
RB1
P06400
direct interaction
8867812
595
CCND1
P24385
5111
PCNA
P12004
physical association
7903056
595
CCND1
P24385
1019
CDK4
P11802
physical association
10580009
595
CCND1
P24385
1027
CDKN1B
P46527
physical association
19556892
595
CCND1
P24385
1026
CDKN1A
P38936
direct interaction
8657154
595
CCND1
P24385
983
CDK1
P06493
physical association
7903056
595
CCND1
P24385
7249
TSC2
P49815
physical association
16357142
595
CCND1
P24385
595
CCND1
P24385
direct interaction
11940657
595
CCND1
P24385
1019
CDK4
P11802
physical association
12036906
595
CCND1
P24385
1027
CDKN1B
P46527
physical association
12036906
595
CCND1
P24385
1029
CDKN2A
Q8N726
colocalization
17420273
595
CCND1
P24385
1026
CDKN1A
P38936
colocalization
17420273
595
CCND1
P24385
1019
CDK4
P11802
colocalization
17420273
595
CCND1
P24385
1026
CDKN1A
P38936
physical association
17556661
595
CCND1
P24385
367
AR
P10275
physical association
10344732
595
CCND1
P24385
367
AR
P10275
direct interaction
15558026
595
CCND1
P24385
367
AR
P10275
physical association
15558026
595
CCND1
P24385
2099
ESR1
P03372
direct interaction
9039267
595
CCND1
P24385
2099
ESR1
P03372
direct interaction
9039267
595
CCND1
P24385
1019
CDK4
P11802
physical association
18537972
595
CCND1
P24385
2099
ESR1
P03372
physical association
16061635
595
CCND1
P24385
1019
CDK4
P11802
physical association
8978686
595
CCND1
P24385
1027
CDKN1B
P46527
physical association
8978686
595
CCND1
P24385
1019
CDK4
P11802
physical association
17205132
595
CCND1
P24385
6774
STAT3
P40763
physical association
15659654
595
CCND1
P24385
5925
RB1
P06400
physical association
15485920
595
CCND1
P24385
5925
RB1
P06400
direct interaction
15485920
595
CCND1
P24385
1019
CDK4
P11802
colocalization
12519773
595
CCND1
P24385
5925
RB1
P06400
direct interaction
11593423
595
CCND1
P24385
5925
RB1
P06400
direct interaction
10491434
595
CCND1
P24385
6774
STAT3
P40763
physical association
11279133
595
CCND1
P24385
5111
PCNA
P12004
physical association
8101826
595
CCND1
P24385
1026
CDKN1A
P38936
physical association
15695403
595
CCND1
P24385
1027
CDKN1B
P46527
physical association
15695403
896
CCND3
P30281
5111
PCNA
P12004
direct interaction
7908906
896
CCND3
P30281
1019
CDK4
P11802
physical association
9716181
896
CCND3
P30281
1027
CDKN1B
P46527
physical association
9716181
896
CCND3
P30281
1026
CDKN1A
P38936
physical association
9716181
896
CCND3
P30281
1017
CDK2
P24941
physical association
9716181
896
CCND3
P30281
7249
TSC2
P49815
physical association
16357142
896
CCND3
P30281
1027
CDKN1B
P46527
physical association
8978686
896
CCND3
P30281
1027
CDKN1B
P46527
physical association
16782892
896
CCND3
P30281
1017
CDK2
P24941
physical association
16782892
896
CCND3
P30281
1019
CDK4
P11802
physical association
16782892
896
CCND3
P30281
5925
RB1
P06400
physical association
16782892
896
CCND3
P30281
1019
CDK4
P11802
physical association
14641107
896
CCND3
P30281
1026
CDKN1A
P38936
direct interaction
16189514
896
CCND3
P30281
1019
CDK4
P11802
direct interaction
16189514
896
CCND3
P30281
1027
CDKN1B
P46527
direct interaction
16189514
896
CCND3
P30281
1027
CDKN1B
P46527
physical association
10597239
898
CCNE1
P24864
983
CDK1
P06493
physical association
9053846
898
CCNE1
P24864
5925
RB1
P06400
direct interaction
9053846
898
CCNE1
P24864
1017
CDK2
P24941
physical association
21372285
898
CCNE1
P24864
367
AR
P10275
physical association
10953010
898
CCNE1
P24864
5925
RB1
P06400
direct interaction
8647086
898
CCNE1
P24864
1017
CDK2
P24941
physical association
12839982
898
CCNE1
P24864
1017
CDK2
P24941
physical association
20837141
898
CCNE1
P24864
1027
CDKN1B
P46527
physical association
20837141
898
CCNE1
P24864
1026
CDKN1A
P38936
physical association
12839982
898
CCNE1
P24864
1019
CDK4
P11802
physical association
9716181
898
CCNE1
P24864
1027
CDKN1B
P46527
physical association
9716181
898
CCNE1
P24864
1026
CDKN1A
P38936
physical association
9716181
898
CCNE1
P24864
1017
CDK2
P24941
physical association
9716181
898
CCNE1
P24864
1027
CDKN1B
P46527
physical association
9632134
898
CCNE1
P24864
1026
CDKN1A
P38936
physical association
9632134
898
CCNE1
P24864
1026
CDKN1A
P38936
physical association
9380407
898
CCNE1
P24864
1026
CDKN1A
P38936
physical association
9218599
898
CCNE1
P24864
1027
CDKN1B
P46527
physical association
9218599
898
CCNE1
P24864
1027
CDKN1B
P46527
physical association
9192873
898
CCNE1
P24864
1017
CDK2
P24941
physical association
9192873
898
CCNE1
P24864
1027
CDKN1B
P46527
direct interaction
9192873
898
CCNE1
P24864
1027
CDKN1B
P46527
direct interaction
10393546
898
CCNE1
P24864
5925
RB1
P06400
direct interaction
10359664
898
CCNE1
P24864
1017
CDK2
P24941
physical association
9891079
898
CCNE1
P24864
1027
CDKN1B
P46527
physical association
9891079
898
CCNE1
P24864
983
CDK1
P06493
physical association
9891079
898
CCNE1
P24864
1027
CDKN1B
P46527
direct interaction
10393546
898
CCNE1
P24864
1027
CDKN1B
P46527
physical association
11940657
898
CCNE1
P24864
1017
CDK2
P24941
physical association
11940657
898
CCNE1
P24864
1027
CDKN1B
P46527
direct interaction
11940657
898
CCNE1
P24864
1027
CDKN1B
P46527
physical association
17293600
898
CCNE1
P24864
1026
CDKN1A
P38936
physical association
17293600
898
CCNE1
P24864
1017
CDK2
P24941
physical association
12529437
898
CCNE1
P24864
1027
CDKN1B
P46527
physical association
12529437
898
CCNE1
P24864
1017
CDK2
P24941
physical association
16223725
898
CCNE1
P24864
1017
CDK2
P24941
association
1388288
898
CCNE1
P24864
983
CDK1
P06493
association
1388288
898
CCNE1
P24864
1017
CDK2
P24941
physical association
1388288
898
CCNE1
P24864
983
CDK1
P06493
physical association
1388288
898
CCNE1
P24864
5925
RB1
P06400
direct interaction
10499802
898
CCNE1
P24864
1017
CDK2
P24941
physical association
8978686
898
CCNE1
P24864
1027
CDKN1B
P46527
physical association
8978686
898
CCNE1
P24864
1026
CDKN1A
P38936
physical association
13678583
898
CCNE1
P24864
1017
CDK2
P24941
physical association
17431037
898
CCNE1
P24864
1017
CDK2
P24941
physical association
17361108
898
CCNE1
P24864
1017
CDK2
P24941
direct interaction
15004009
898
CCNE1
P24864
1017
CDK2
P24941
physical association
17970072
898
CCNE1
P24864
4683
NBN
O60934
physical association
12607005
898
CCNE1
P24864
4361
MRE11A
P49959
physical association
12607005
898
CCNE1
P24864
55294
FBXW7
Q969H0
direct interaction
11565034
898
CCNE1
P24864
1017
CDK2
P24941
physical association
14701826
898
CCNE1
P24864
1017
CDK2
P24941
physical association
15514162
898
CCNE1
P24864
1017
CDK2
P24941
physical association
18559665
898
CCNE1
P24864
1017
CDK2
P24941
physical association
12800980
898
CCNE1
P24864
2305
FOXM1
Q08050
physical association
15024056
898
CCNE1
P24864
55294
FBXW7
Q969H0
direct interaction
15364936
9134
CCNE2
O96020
1017
CDK2
P24941
physical association
9840927
9134
CCNE2
O96020
1027
CDKN1B
P46527
physical association
9840927
9134
CCNE2
O96020
1026
CDKN1A
P38936
physical association
9840927
9134
CCNE2
O96020
1017
CDK2
P24941
physical association
9858585
9134
CCNE2
O96020
55294
FBXW7
Q969H0
physical association
19084516
999
CDH1
P12830
1500
CTNND1
O60716
colocalization
20371349
999
CDH1
P12830
1500
CTNND1
O60716
association
20371349
999
CDH1
P12830
1500
CTNND1
O60716
direct interaction
20371349
999
CDH1
P12830
1499
CTNNB1
P35222
physical association
11960376
999
CDH1
P12830
1499
CTNNB1
P35222
physical association
12634428
999
CDH1
P12830
1500
CTNND1
O60716
direct interaction
12640114
999
CDH1
P12830
1500
CTNND1
O60716
direct interaction
7651399
999
CDH1
P12830
1499
CTNNB1
P35222
physical association
17220478
999
CDH1
P12830
10397
NDRG1
Q92597
physical association
17220478
999
CDH1
P12830
1500
CTNND1
O60716
physical association
22715382
999
CDH1
P12830
1499
CTNNB1
P35222
physical association
22715382
999
CDH1
P12830
1956
EGFR
P00533
physical association
10969083
999
CDH1
P12830
1499
CTNNB1
P35222
physical association
9405455
999
CDH1
P12830
6714
SRC
P12931
physical association
10744074
999
CDH1
P12830
1499
CTNNB1
P35222
physical association
11254878
999
CDH1
P12830
4233
MET
P08581
physical association
11254878
999
CDH1
P12830
1499
CTNNB1
P35222
physical association
8227214
999
CDH1
P12830
1500
CTNND1
O60716
physical association
7651399
999
CDH1
P12830
999
CDH1
P12830
association
10910767
999
CDH1
P12830
1001
CDH3
P22223
physical association
10910767
999
CDH1
P12830
999
CDH1
P12830
physical association
10910767
999
CDH1
P12830
999
CDH1
P12830
direct interaction
10202138
999
CDH1
P12830
1499
CTNNB1
P35222
physical association
7542250
999
CDH1
P12830
1500
CTNND1
O60716
physical association
7542250
999
CDH1
P12830
1499
CTNNB1
P35222
physical association
16125672
999
CDH1
P12830
1499
CTNNB1
P35222
physical association
12061792
999
CDH1
P12830
1500
CTNND1
O60716
physical association
9535896
999
CDH1
P12830
1499
CTNNB1
P35222
physical association
9535896
999
CDH1
P12830
891
CCNB1
P14635
direct interaction
20383333
999
CDH1
P12830
2033
EP300
Q09472
physical association
16319895
999
CDH1
P12830
87
ACTN1
P12814
physical association
9535896
999
CDH1
P12830
2305
FOXM1
Q08050
physical association
18758239
999
CDH1
P12830
1499
CTNNB1
P35222
association
11348595
999
CDH1
P12830
1499
CTNNB1
P35222
physical association
11245482
999
CDH1
P12830
1499
CTNNB1
P35222
physical association
9819408
999
CDH1
P12830
1001
CDH3
P22223
association
10910767
999
CDH1
P12830
1499
CTNNB1
P35222
physical association
9233779
999
CDH1
P12830
4193
MDM2
Q00987
direct interaction
16980628
999
CDH1
P12830
4193
MDM2
Q00987
physical association
16980628
999
CDH1
P12830
1499
CTNNB1
P35222
physical association
7876318
999
CDH1
P12830
1500
CTNND1
O60716
physical association
7876318
999
CDH1
P12830
1499
CTNNB1
P35222
physical association
12169098
999
CDH1
P12830
1499
CTNNB1
P35222
physical association
10772923
1000
CDH2
P19022
1499
CTNNB1
P35222
physical association
11835406
1000
CDH2
P19022
1500
CTNND1
O60716
physical association
12604612
1000
CDH2
P19022
1499
CTNNB1
P35222
physical association
12604612
1000
CDH2
P19022
1499
CTNNB1
P35222
physical association
12077367
1000
CDH2
P19022
1500
CTNND1
O60716
physical association
14625392
1000
CDH2
P19022
1499
CTNNB1
P35222
physical association
14625392
1001
CDH3
P22223
999
CDH1
P12830
physical association
10910767
1001
CDH3
P22223
1499
CTNNB1
P35222
association
10910767
1001
CDH3
P22223
1499
CTNNB1
P35222
physical association
10910767
1001
CDH3
P22223
1001
CDH3
P22223
physical association
10910767
1001
CDH3
P22223
1001
CDH3
P22223
association
10910767
983
CDK1
P06493
5925
RB1
P06400
direct interaction
9053846
983
CDK1
P06493
595
CCND1
P24385
physical association
7903056
983
CDK1
P06493
6667
SP1
P08047
direct interaction
22266860
983
CDK1
P06493
6667
SP1
P08047
physical association
22266860
983
CDK1
P06493
6117
RPA1
P27694
direct interaction
8397207
983
CDK1
P06493
891
CCNB1
P14635
direct interaction
8397207
983
CDK1
P06493
891
CCNB1
P14635
colocalization
8397207
983
CDK1
P06493
891
CCNB1
P14635
direct interaction
7799941
983
CDK1
P06493
1027
CDKN1B
P46527
physical association
18615582
983
CDK1
P06493
7248
TSC1
Q92574
direct interaction
14551205
983
CDK1
P06493
7157
TP53
P04637
physical association
11327730
983
CDK1
P06493
891
CCNB1
P14635
physical association
10973963
983
CDK1
P06493
891
CCNB1
P14635
physical association
20367638
983
CDK1
P06493
891
CCNB1
P14635
association
8397206
983
CDK1
P06493
6117
RPA1
P27694
direct interaction
8397206
983
CDK1
P06493
1026
CDKN1A
P38936
physical association
17679094
983
CDK1
P06493
7329
UBE2I
P63279
direct interaction
22407595
983
CDK1
P06493
861
RUNX1
Q01196
direct interaction
21059642
983
CDK1
P06493
4288
MKI67
P46013
direct interaction
10502411
983
CDK1
P06493
3146
HMGB1
P09429
direct interaction
2013279
983
CDK1
P06493
3146
HMGB1
P09429
direct interaction
2013279
983
CDK1
P06493
1026
CDKN1A
P38936
physical association
21308745
983
CDK1
P06493
983
CDK1
P06493
physical association
21308745
983
CDK1
P06493
2305
FOXM1
Q08050
physical association
15024056
983
CDK1
P06493
2305
FOXM1
Q08050
direct interaction
15024056
983
CDK1
P06493
891
CCNB1
P14635
physical association
10716937
983
CDK1
P06493
7157
TP53
P04637
direct interaction
10884347
1017
CDK2
P24941
3399
ID3
Q02535
direct interaction
9372912
1017
CDK2
P24941
5925
RB1
P06400
direct interaction
9053846
1017
CDK2
P24941
595
CCND1
P24385
physical association
8647086
1017
CDK2
P24941
898
CCNE1
P24864
physical association
8647086
1017
CDK2
P24941
898
CCNE1
P24864
direct interaction
8647086
1017
CDK2
P24941
595
CCND1
P24385
direct interaction
8647086
1017
CDK2
P24941
5925
RB1
P06400
direct interaction
8647086
1017
CDK2
P24941
898
CCNE1
P24864
physical association
8867812
1017
CDK2
P24941
898
CCNE1
P24864
physical association
19631451
1017
CDK2
P24941
1027
CDKN1B
P46527
physical association
19631451
1017
CDK2
P24941
5925
RB1
P06400
direct interaction
15003538
1017
CDK2
P24941
5111
PCNA
P12004
physical association
7903056
1017
CDK2
P24941
1027
CDKN1B
P46527
physical association
10198259
1017
CDK2
P24941
7157
TP53
P04637
direct interaction
19556892
1017
CDK2
P24941
1027
CDKN1B
P46527
physical association
9658399
1017
CDK2
P24941
1026
CDKN1A
P38936
physical association
9658399
1017
CDK2
P24941
1027
CDKN1B
P46527
physical association
9632134
1017
CDK2
P24941
1026
CDKN1A
P38936
physical association
9632134
1017
CDK2
P24941
1027
CDKN1B
P46527
physical association
9380407
1017
CDK2
P24941
1026
CDKN1A
P38936
physical association
9380407
1017
CDK2
P24941
5925
RB1
P06400
direct interaction
20871633
1017
CDK2
P24941
6117
RPA1
P27694
direct interaction
8397207
1017
CDK2
P24941
891
CCNB1
P14635
direct interaction
8397207
1017
CDK2
P24941
5925
RB1
P06400
direct interaction
15173007
1017
CDK2
P24941
1026
CDKN1A
P38936
physical association
9218599
1017
CDK2
P24941
1027
CDKN1B
P46527
physical association
9218599
1017
CDK2
P24941
1027
CDKN1B
P46527
direct interaction
9192873
1017
CDK2
P24941
898
CCNE1
P24864
physical association
20587660
1017
CDK2
P24941
1026
CDKN1A
P38936
physical association
20587660
1017
CDK2
P24941
1026
CDKN1A
P38936
direct interaction
8242751
1017
CDK2
P24941
1026
CDKN1A
P38936
direct interaction
8242751
1017
CDK2
P24941
898
CCNE1
P24864
direct interaction
10359664
1017
CDK2
P24941
898
CCNE1
P24864
direct interaction
7799941
1017
CDK2
P24941
891
CCNB1
P14635
direct interaction
7799941
1017
CDK2
P24941
5925
RB1
P06400
direct interaction
21697511
1017
CDK2
P24941
1027
CDKN1B
P46527
direct interaction
10393546
1017
CDK2
P24941
1027
CDKN1B
P46527
direct interaction
10393546
1017
CDK2
P24941
1026
CDKN1A
P38936
physical association
12417722
1017
CDK2
P24941
1027
CDKN1B
P46527
physical association
12417722
1017
CDK2
P24941
1027
CDKN1B
P46527
physical association
18615582
1017
CDK2
P24941
5925
RB1
P06400
direct interaction
19225156
1017
CDK2
P24941
6117
RPA1
P27694
direct interaction
8397206
1017
CDK2
P24941
1027
CDKN1B
P46527
physical association
10585280
1017
CDK2
P24941
1026
CDKN1A
P38936
physical association
10874474
1017
CDK2
P24941
1026
CDKN1A
P38936
physical association
10918595
1017
CDK2
P24941
5925
RB1
P06400
direct interaction
10499802
1017
CDK2
P24941
5925
RB1
P06400
direct interaction
10938106
1017
CDK2
P24941
983
CDK1
P06493
physical association
21319273
1017
CDK2
P24941
836
CASP3
P42574
physical association
21319273
1017
CDK2
P24941
3615
IMPDH2
P12268
physical association
21319273
1017
CDK2
P24941
87
ACTN1
P12814
physical association
21319273
1017
CDK2
P24941
5725
PTBP1
P26599
physical association
21319273
1017
CDK2
P24941
3925
STMN1
P16949
physical association
21319273
1017
CDK2
P24941
5111
PCNA
P12004
physical association
21319273
1017
CDK2
P24941
8407
TAGLN2
P37802
physical association
21319273
1017
CDK2
P24941
1665
DHX15
O43143
physical association
21319273
1017
CDK2
P24941
1993
ELAVL2
Q12926
physical association
21319273
1017
CDK2
P24941
7329
UBE2I
P63279
physical association
21319273
1017
CDK2
P24941
3838
KPNA2
P52292
physical association
21319273
1017
CDK2
P24941
4191
MDH2
P40926
physical association
21319273
1017
CDK2
P24941
9230
RAB11B
Q15907
physical association
21319273
1017
CDK2
P24941
1027
CDKN1B
P46527
physical association
8978686
1017
CDK2
P24941
440
ASNS
P08243
physical association
21319273
1017
CDK2
P24941
7334
UBE2N
P61088
physical association
21319273
1017
CDK2
P24941
3032
HADHB
P55084
physical association
21319273
1017
CDK2
P24941
60
ACTB
P60709
physical association
21319273
1017
CDK2
P24941
2597
GAPDH
P04406
physical association
21319273
1017
CDK2
P24941
378
ARF4
P18085
physical association
21319273
1017
CDK2
P24941
6223
RPS19
P39019
physical association
21319273
1017
CDK2
P24941
1027
CDKN1B
P46527
physical association
15647383
1017
CDK2
P24941
1026
CDKN1A
P38936
physical association
15647383
1017
CDK2
P24941
7534
YWHAZ
P63104
physical association
21319273
1017
CDK2
P24941
5216
PFN1
P07737
physical association
21319273
1017
CDK2
P24941
1017
CDK2
P24941
physical association
21319273
1017
CDK2
P24941
5094
PCBP2
Q15366
physical association
21319273
1017
CDK2
P24941
6406
SEMG1
P04279
physical association
21319273
1017
CDK2
P24941
7531
YWHAE
P62258
physical association
21319273
1017
CDK2
P24941
898
CCNE1
P24864
colocalization
11132966
1017
CDK2
P24941
1026
CDKN1A
P38936
colocalization
11132966
1017
CDK2
P24941
7520
XRCC5
P13010
physical association
21319273
1017
CDK2
P24941
3146
HMGB1
P09429
physical association
21319273
1017
CDK2
P24941
2194
FASN
P49327
physical association
21319273
1017
CDK2
P24941
3329
HSPD1
P10809
physical association
21319273
1017
CDK2
P24941
1938
EEF2
P13639
physical association
21319273
1017
CDK2
P24941
6279
S100A8
P05109
physical association
21319273
1017
CDK2
P24941
4627
MYH9
P35579
physical association
21319273
1017
CDK2
P24941
3945
LDHB
P07195
physical association
21319273
1017
CDK2
P24941
376267
RAB15
P59190
physical association
21319273
1017
CDK2
P24941
506
ATP5B
P06576
physical association
21319273
1017
CDK2
P24941
5925
RB1
P06400
direct interaction
15811853
1017
CDK2
P24941
1026
CDKN1A
P38936
physical association
13678583
1017
CDK2
P24941
5241
PGR
P06401
physical association
21447625
1017
CDK2
P24941
1017
CDK2
P24941
direct interaction
17361108
1017
CDK2
P24941
5925
RB1
P06400
direct interaction
12190313
1017
CDK2
P24941
1027
CDKN1B
P46527
direct interaction
17671428
1017
CDK2
P24941
5583
PRKCH
P24723
physical association
11175348
1017
CDK2
P24941
5111
PCNA
P12004
physical association
10930425
1017
CDK2
P24941
1026
CDKN1A
P38936
physical association
18850315
1017
CDK2
P24941
1027
CDKN1B
P46527
physical association
18850315
1017
CDK2
P24941
6667
SP1
P08047
direct interaction
11598016
1017
CDK2
P24941
898
CCNE1
P24864
physical association
14701826
1017
CDK2
P24941
5925
RB1
P06400
direct interaction
12800980
1017
CDK2
P24941
5925
RB1
P06400
direct interaction
14681231
1017
CDK2
P24941
1026
CDKN1A
P38936
physical association
12949733
1017
CDK2
P24941
5925
RB1
P06400
direct interaction
12970441
1017
CDK2
P24941
1026
CDKN1A
P38936
physical association
12800980
1017
CDK2
P24941
1027
CDKN1B
P46527
physical association
12800980
1017
CDK2
P24941
898
CCNE1
P24864
physical association
12800980
1017
CDK2
P24941
1026
CDKN1A
P38936
physical association
15557281
1017
CDK2
P24941
898
CCNE1
P24864
physical association
15557281
1017
CDK2
P24941
1027
CDKN1B
P46527
physical association
15557281
1017
CDK2
P24941
4286
MITF
O75030
suppressive genetic interaction defined by inequality
15607961
1017
CDK2
P24941
898
CCNE1
P24864
physical association
15670215
1017
CDK2
P24941
2305
FOXM1
Q08050
physical association
15024056
1017
CDK2
P24941
898
CCNE1
P24864
direct interaction
10827081
1017
CDK2
P24941
1026
CDKN1A
P38936
physical association
9858587
1017
CDK2
P24941
1027
CDKN1B
P46527
physical association
15619620
1017
CDK2
P24941
7157
TP53
P04637
direct interaction
10884347
1017
CDK2
P24941
1027
CDKN1B
P46527
physical association
12972555
1017
CDK2
P24941
891
CCNB1
P14635
direct interaction
10995390
1019
CDK4
P11802
5925
RB1
P06400
direct interaction
16985050
1019
CDK4
P11802
896
CCND3
P30281
physical association
16985050
1019
CDK4
P11802
595
CCND1
P24385
physical association
16985050
1019
CDK4
P11802
1029
CDKN2A
Q8N726
direct interaction
11900540
1019
CDK4
P11802
5925
RB1
P06400
direct interaction
11900540
1019
CDK4
P11802
1029
CDKN2A
Q8N726
physical association
17353931
1019
CDK4
P11802
5925
RB1
P06400
direct interaction
8647086
1019
CDK4
P11802
595
CCND1
P24385
physical association
8867812
1019
CDK4
P11802
5925
RB1
P06400
direct interaction
8867812
1019
CDK4
P11802
5925
RB1
P06400
direct interaction
15003538
1019
CDK4
P11802
5925
RB1
P06400
physical association
10198259
1019
CDK4
P11802
1027
CDKN1B
P46527
physical association
10198259
1019
CDK4
P11802
595
CCND1
P24385
direct interaction
10580009
1019
CDK4
P11802
595
CCND1
P24385
physical association
20837141
1019
CDK4
P11802
1027
CDKN1B
P46527
physical association
20837141
1019
CDK4
P11802
1029
CDKN2A
Q8N726
physical association
8259215
1019
CDK4
P11802
595
CCND1
P24385
physical association
8259215
1019
CDK4
P11802
1029
CDKN2A
Q8N726
direct interaction
8259215
1019
CDK4
P11802
1029
CDKN2A
Q8N726
direct interaction
8259215
1019
CDK4
P11802
5111
PCNA
P12004
physical association
8259215
1019
CDK4
P11802
5925
RB1
P06400
direct interaction
19556892
1019
CDK4
P11802
1027
CDKN1B
P46527
physical association
9658399
1019
CDK4
P11802
1026
CDKN1A
P38936
physical association
9658399
1019
CDK4
P11802
1027
CDKN1B
P46527
physical association
9632134
1019
CDK4
P11802
1026
CDKN1A
P38936
physical association
9632134
1019
CDK4
P11802
5925
RB1
P06400
direct interaction
12509456
1019
CDK4
P11802
1027
CDKN1B
P46527
physical association
18615582
1019
CDK4
P11802
5925
RB1
P06400
direct interaction
19225156
1019
CDK4
P11802
1026
CDKN1A
P38936
physical association
17556661
1019
CDK4
P11802
5925
RB1
P06400
direct interaction
15147269
1019
CDK4
P11802
5925
RB1
P06400
direct interaction
15998794
1019
CDK4
P11802
595
CCND1
P24385
physical association
9372967
1019
CDK4
P11802
595
CCND1
P24385
physical association
18537972
1019
CDK4
P11802
896
CCND3
P30281
physical association
10342870
1019
CDK4
P11802
1029
CDKN2A
Q8N726
direct interaction
17881001
1019
CDK4
P11802
1029
CDKN2A
Q8N726
direct interaction
10719365
1019
CDK4
P11802
5925
RB1
P06400
direct interaction
15922743
1019
CDK4
P11802
896
CCND3
P30281
physical association
11360184
1019
CDK4
P11802
595
CCND1
P24385
physical association
11360184
1019
CDK4
P11802
506
ATP5B
P06576
direct interaction
21900206
1019
CDK4
P11802
5925
RB1
P06400
direct interaction
12190313
1019
CDK4
P11802
1027
CDKN1B
P46527
physical association
18850315
1019
CDK4
P11802
1026
CDKN1A
P38936
physical association
18850315
1019
CDK4
P11802
5925
RB1
P06400
direct interaction
12519773
1019
CDK4
P11802
5925
RB1
P06400
direct interaction
15169570
1019
CDK4
P11802
5925
RB1
P06400
direct interaction
12949733
1019
CDK4
P11802
5925
RB1
P06400
direct interaction
16205633
1019
CDK4
P11802
1029
CDKN2A
Q8N726
direct interaction
9228064
1019
CDK4
P11802
595
CCND1
P24385
direct interaction
9228064
1019
CDK4
P11802
595
CCND1
P24385
physical association
10908655
1019
CDK4
P11802
1027
CDKN1B
P46527
physical association
10908655
1019
CDK4
P11802
5111
PCNA
P12004
physical association
8101826
1019
CDK4
P11802
1027
CDKN1B
P46527
physical association
15695403
1019
CDK4
P11802
1026
CDKN1A
P38936
physical association
15695403
1026
CDKN1A
P38936
5111
PCNA
P12004
direct interaction
22383522
1026
CDKN1A
P38936
898
CCNE1
P24864
physical association
8891332
1026
CDKN1A
P38936
5111
PCNA
P12004
association
8861913
1026
CDKN1A
P38936
2099
ESR1
P03372
direct interaction
17911387
1026
CDKN1A
P38936
898
CCNE1
P24864
physical association
12839982
1026
CDKN1A
P38936
1017
CDK2
P24941
physical association
12839982
1026
CDKN1A
P38936
1017
CDK2
P24941
direct interaction
12839982
1026
CDKN1A
P38936
983
CDK1
P06493
physical association
11559705
1026
CDKN1A
P38936
891
CCNB1
P14635
physical association
11559705
1026
CDKN1A
P38936
5111
PCNA
P12004
physical association
11559705
1026
CDKN1A
P38936
5111
PCNA
P12004
physical association
17588519
1026
CDKN1A
P38936
5111
PCNA
P12004
direct interaction
9465025
1026
CDKN1A
P38936
5111
PCNA
P12004
physical association
20606006
1026
CDKN1A
P38936
1019
CDK4
P11802
physical association
17556661
1026
CDKN1A
P38936
595
CCND1
P24385
physical association
17556661
1026
CDKN1A
P38936
4780
NFE2L2
Q16236
physical association
19560419
1026
CDKN1A
P38936
4193
MDM2
Q00987
physical association
14761977
1026
CDKN1A
P38936
595
CCND1
P24385
direct interaction
16082198
1026
CDKN1A
P38936
9759
HDAC4
P56524
direct interaction
16082198
1026
CDKN1A
P38936
891
CCNB1
P14635
direct interaction
16082198
1026
CDKN1A
P38936
5111
PCNA
P12004
direct interaction
16082198
1026
CDKN1A
P38936
1017
CDK2
P24941
physical association
10878006
1026
CDKN1A
P38936
5111
PCNA
P12004
physical association
11313979
1026
CDKN1A
P38936
2597
GAPDH
P04406
physical association
16474839
1026
CDKN1A
P38936
5111
PCNA
P12004
direct interaction
16474839
1026
CDKN1A
P38936
2597
GAPDH
P04406
direct interaction
16474839
1026
CDKN1A
P38936
5111
PCNA
P12004
colocalization
18086887
1026
CDKN1A
P38936
2033
EP300
Q09472
direct interaction
18263614
1026
CDKN1A
P38936
2033
EP300
Q09472
physical association
18263614
1026
CDKN1A
P38936
1017
CDK2
P24941
physical association
12383116
1026
CDKN1A
P38936
1019
CDK4
P11802
physical association
12383116
1026
CDKN1A
P38936
595
CCND1
P24385
physical association
12383116
1026
CDKN1A
P38936
4193
MDM2
Q00987
physical association
20086099
1026
CDKN1A
P38936
1027
CDKN1B
P46527
additive genetic interaction defined by inequality
18850315
1026
CDKN1A
P38936
898
CCNE1
P24864
physical association
11477082
1026
CDKN1A
P38936
1017
CDK2
P24941
physical association
11477082
1026
CDKN1A
P38936
4193
MDM2
Q00987
direct interaction
20308078
1026
CDKN1A
P38936
3725
JUN
P05412
physical association
20102411
1026
CDKN1A
P38936
1019
CDK4
P11802
physical association
15169570
1026
CDKN1A
P38936
5111
PCNA
P12004
direct interaction
16189514
1026
CDKN1A
P38936
1017
CDK2
P24941
physical association
12800980
1026
CDKN1A
P38936
5599
MAPK8
P45983
physical association
20102411
1026
CDKN1A
P38936
1017
CDK2
P24941
physical association
20102411
1026
CDKN1A
P38936
1019
CDK4
P11802
physical association
20102411
1026
CDKN1A
P38936
5111
PCNA
P12004
physical association
20605778
1026
CDKN1A
P38936
4193
MDM2
Q00987
direct interaction
14633995
1026
CDKN1A
P38936
4193
MDM2
Q00987
physical association
14633995
1026
CDKN1A
P38936
5111
PCNA
P12004
direct interaction
12930846
1026
CDKN1A
P38936
2244
FGB
P02675
direct interaction
21900206
1026
CDKN1A
P38936
506
ATP5B
P06576
direct interaction
21900206
1026
CDKN1A
P38936
1508
CTSB
P07858
direct interaction
21900206
1026
CDKN1A
P38936
2
A2M
P01023
direct interaction
21900206
1026
CDKN1A
P38936
60
ACTB
P60709
direct interaction
21900206
1026
CDKN1A
P38936
3104
ZBTB48
P10074
direct interaction
21900206
1026
CDKN1A
P38936
3032
HADHB
P55084
direct interaction
21900206
1026
CDKN1A
P38936
7157
TP53
P04637
direct interaction
21900206
1026
CDKN1A
P38936
6279
S100A8
P05109
direct interaction
21900206
1027
CDKN1B
P46527
207
AKT1
P31749
physical association
12042314
1027
CDKN1B
P46527
898
CCNE1
P24864
physical association
8891332
1027
CDKN1B
P46527
7249
TSC2
P49815
physical association
15355997
1027
CDKN1B
P46527
7248
TSC1
Q92574
physical association
15355997
1027
CDKN1B
P46527
1017
CDK2
P24941
physical association
15355997
1027
CDKN1B
P46527
1017
CDK2
P24941
direct interaction
9724724
1027
CDKN1B
P46527
1017
CDK2
P24941
physical association
11940657
1027
CDKN1B
P46527
595
CCND1
P24385
direct interaction
11940657
1027
CDKN1B
P46527
1019
CDK4
P11802
direct interaction
11940657
1027
CDKN1B
P46527
1017
CDK2
P24941
direct interaction
11940657
1027
CDKN1B
P46527
898
CCNE1
P24864
direct interaction
11940657
1027
CDKN1B
P46527
898
CCNE1
P24864
physical association
12529437
1027
CDKN1B
P46527
1017
CDK2
P24941
physical association
12529437
1027
CDKN1B
P46527
1019
CDK4
P11802
physical association
18285702
1027
CDKN1B
P46527
1017
CDK2
P24941
physical association
18285702
1027
CDKN1B
P46527
7531
YWHAE
P62258
physical association
15057270
1027
CDKN1B
P46527
896
CCND3
P30281
physical association
10342870
1027
CDKN1B
P46527
1017
CDK2
P24941
physical association
8978686
1027
CDKN1B
P46527
1019
CDK4
P11802
physical association
8978686
1027
CDKN1B
P46527
1019
CDK4
P11802
physical association
9311993
1027
CDKN1B
P46527
898
CCNE1
P24864
physical association
9311993
1027
CDKN1B
P46527
1017
CDK2
P24941
physical association
9311993
1027
CDKN1B
P46527
595
CCND1
P24385
physical association
9311993
1027
CDKN1B
P46527
896
CCND3
P30281
direct interaction
11360184
1027
CDKN1B
P46527
595
CCND1
P24385
direct interaction
11360184
1027
CDKN1B
P46527
896
CCND3
P30281
physical association
11360184
1027
CDKN1B
P46527
1019
CDK4
P11802
direct interaction
11360184
1027
CDKN1B
P46527
896
CCND3
P30281
physical association
16782892
1027
CDKN1B
P46527
1017
CDK2
P24941
physical association
16782892
1027
CDKN1B
P46527
1019
CDK4
P11802
physical association
16782892
1027
CDKN1B
P46527
1017
CDK2
P24941
physical association
12800980
1027
CDKN1B
P46527
896
CCND3
P30281
physical association
10597239
1029
CDKN2A
Q8N726
1019
CDK4
P11802
direct interaction
11900540
1029
CDKN2A
Q8N726
4193
MDM2
Q00987
physical association
16173922
1029
CDKN2A
Q8N726
4193
MDM2
Q00987
direct interaction
16173922
1029
CDKN2A
Q8N726
1019
CDK4
P11802
direct interaction
10580009
1029
CDKN2A
Q8N726
595
CCND1
P24385
direct interaction
10580009
1029
CDKN2A
Q8N726
4193
MDM2
Q00987
physical association
21133853
1029
CDKN2A
Q8N726
1019
CDK4
P11802
direct interaction
8805225
1029
CDKN2A
Q8N726
4609
MYC
P01106
physical association
20308430
1029
CDKN2A
Q8N726
1019
CDK4
P11802
physical association
10585280
1029
CDKN2A
Q8N726
4193
MDM2
Q00987
physical association
17426254
1029
CDKN2A
Q8N726
1019
CDK4
P11802
direct interaction
9529249
1029
CDKN2A
Q8N726
4193
MDM2
Q00987
physical association
20395212
1029
CDKN2A
Q8N726
7157
TP53
P04637
physical association
20395212
1029
CDKN2A
Q8N726
4193
MDM2
Q00987
direct interaction
15355988
1029
CDKN2A
Q8N726
4193
MDM2
Q00987
physical association
12085228
1029
CDKN2A
Q8N726
4193
MDM2
Q00987
direct interaction
10871849
1029
CDKN2A
Q8N726
6667
SP1
P08047
physical association
21555589
1029
CDKN2A
Q8N726
7428
VHL
P40337
physical association
21942715
1029
CDKN2A
Q8N726
1019
CDK4
P11802
physical association
17881001
1029
CDKN2A
Q8N726
1019
CDK4
P11802
direct interaction
15065884
1029
CDKN2A
Q8N726
4193
MDM2
Q00987
physical association
18418067
1029
CDKN2A
Q8N726
7157
TP53
P04637
physical association
14612427
1029
CDKN2A
Q8N726
4193
MDM2
Q00987
physical association
14612427
1029
CDKN2A
Q8N726
1019
CDK4
P11802
direct interaction
10491434
1029
CDKN2A
Q8N726
7157
TP53
P04637
physical association
9529249
1029
CDKN2A
Q8N726
4193
MDM2
Q00987
direct interaction
9529249
1029
CDKN2A
Q8N726
4193
MDM2
Q00987
direct interaction
9529249
1029
CDKN2A
Q8N726
4193
MDM2
Q00987
physical association
9529249
1029
CDKN2A
Q8N726
5111
PCNA
P12004
physical association
17955473
1029
CDKN2A
Q8N726
1938
EEF2
P13639
physical association
17955473
1029
CDKN2A
Q8N726
60
ACTB
P60709
physical association
17955473
1029
CDKN2A
Q8N726
81
ACTN4
O43707
physical association
17955473
1029
CDKN2A
Q8N726
2597
GAPDH
P04406
physical association
17955473
1029
CDKN2A
Q8N726
5111
PCNA
P12004
physical association
17955473
1051
CEBPB
P17676
6667
SP1
P08047
physical association
12665574
1051
CEBPB
P17676
2099
ESR1
P03372
colocalization
19652226
1051
CEBPB
P17676
2932
GSK3B
P49841
physical association
20110283
1051
CEBPB
P17676
1051
CEBPB
P17676
physical association
20110283
1051
CEBPB
P17676
2099
ESR1
P03372
direct interaction
9817600
1051
CEBPB
P17676
367
AR
P10275
direct interaction
9817600
1051
CEBPB
P17676
2033
EP300
Q09472
direct interaction
9343424
1051
CEBPB
P17676
2033
EP300
Q09472
physical association
9343424
1051
CEBPB
P17676
2033
EP300
Q09472
additive genetic interaction defined by inequality
9343424
1051
CEBPB
P17676
6667
SP1
P08047
physical association
16651265
1051
CEBPB
P17676
2099
ESR1
P03372
physical association
16651265
1051
CEBPB
P17676
6774
STAT3
P40763
physical association
18203738
1051
CEBPB
P17676
5925
RB1
P06400
direct interaction
11596110
1051
CEBPB
P17676
1051
CEBPB
P17676
physical association
12618752
1051
CEBPB
P17676
4790
NFKB1
P19838
direct interaction
1518839
1051
CEBPB
P17676
861
RUNX1
Q01196
direct interaction
8622667
10658
CELF1
Q92879
10040
TOM1L1
O75674
direct interaction
16169070
1111
CHEK1
O14757
1786
DNMT1
P26358
physical association
17991895
1111
CHEK1
O14757
207
AKT1
P31749
physical association
17962807
1111
CHEK1
O14757
208
AKT2
P31751
physical association
17962807
1111
CHEK1
O14757
7157
TP53
P04637
direct interaction
10673501
1111
CHEK1
O14757
7520
XRCC5
P13010
physical association
12756247
1111
CHEK1
O14757
7157
TP53
P04637
direct interaction
12756247
1111
CHEK1
O14757
7157
TP53
P04637
physical association
11896572
1111
CHEK1
O14757
1026
CDKN1A
P38936
physical association
11896572
1111
CHEK1
O14757
5925
RB1
P06400
direct interaction
17380128
1111
CHEK1
O14757
5925
RB1
P06400
direct interaction
17380128
11200
CHEK2
O96017
11200
CHEK2
O96017
physical association
12024051
11200
CHEK2
O96017
11200
CHEK2
O96017
direct interaction
12024051
11200
CHEK2
O96017
11200
CHEK2
O96017
direct interaction
12024051
11200
CHEK2
O96017
2305
FOXM1
Q08050
direct interaction
17101782
11200
CHEK2
O96017
11200
CHEK2
O96017
direct interaction
11901158
11200
CHEK2
O96017
11200
CHEK2
O96017
direct interaction
11901158
11200
CHEK2
O96017
7157
TP53
P04637
direct interaction
10673501
11200
CHEK2
O96017
11200
CHEK2
O96017
physical association
11901158
11200
CHEK2
O96017
4193
MDM2
Q00987
physical association
19176998
11200
CHEK2
O96017
675
BRCA2
P51587
direct interaction
14623252
11200
CHEK2
O96017
7157
TP53
P04637
physical association
12810724
11200
CHEK2
O96017
5347
PLK1
P53350
physical association
12493754
11200
CHEK2
O96017
7157
TP53
P04637
direct interaction
15862297
11200
CHEK2
O96017
4193
MDM2
Q00987
direct interaction
15862297
11200
CHEK2
O96017
4193
MDM2
Q00987
direct interaction
15862297
11200
CHEK2
O96017
4193
MDM2
Q00987
direct interaction
16943424
11200
CHEK2
O96017
7157
TP53
P04637
direct interaction
10710310
11200
CHEK2
O96017
5925
RB1
P06400
direct interaction
17380128
11200
CHEK2
O96017
5925
RB1
P06400
physical association
17380128
11200
CHEK2
O96017
5925
RB1
P06400
direct interaction
17380128
11200
CHEK2
O96017
5521
PPP2R2B
Q00005
direct interaction
15380617
11200
CHEK2
O96017
675
BRCA2
P51587
physical association
17525332
11200
CHEK2
O96017
10111
RAD50
Q92878
physical association
17525332
11200
CHEK2
O96017
7158
TP53BP1
Q12888
physical association
17525332
1294
COL7A1
Q02388
2335
FN1
P02751
direct interaction
9169408
1294
COL7A1
Q02388
3918
LAMC2
Q13753
direct interaction
9989793
1294
COL7A1
Q02388
3914
LAMB3
Q13751
direct interaction
9989793
10106
CTDSP2
O14595
6615
SNAI1
O95863
physical association
19004823
1490
CTGF
P29279
7422
VEGFA
P15692
physical association
11744618
1490
CTGF
P29279
60
ACTB
P60709
association
12470643
1490
CTGF
P29279
60
ACTB
P60709
direct interaction
12470643
1499
CTNNB1
P35222
324
APC
P25054
direct interaction
11707392
1499
CTNNB1
P35222
324
APC
P25054
association
11707392
1499
CTNNB1
P35222
324
APC
P25054
direct interaction
15327769
1499
CTNNB1
P35222
324
APC
P25054
direct interaction
15327769
1499
CTNNB1
P35222
324
APC
P25054
association
15327769
1499
CTNNB1
P35222
6925
TCF4
P15884
physical association
22155184
1499
CTNNB1
P35222
999
CDH1
P12830
physical association
12640114
1499
CTNNB1
P35222
3164
NR4A1
P22736
physical association
21986938
1499
CTNNB1
P35222
1001
CDH3
P22223
physical association
10381631
1499
CTNNB1
P35222
999
CDH1
P12830
physical association
10381631
1499
CTNNB1
P35222
999
CDH1
P12830
physical association
12830000
1499
CTNNB1
P35222
6925
TCF4
P15884
direct interaction
12727872
1499
CTNNB1
P35222
7534
YWHAZ
P63104
physical association
22912335
1499
CTNNB1
P35222
999
CDH1
P12830
physical association
17220478
1499
CTNNB1
P35222
10397
NDRG1
Q92597
physical association
17220478
1499
CTNNB1
P35222
10076
PTPRU
Q92729
physical association
12501215
1499
CTNNB1
P35222
2033
EP300
Q09472
additive genetic interaction defined by inequality
12861022
1499
CTNNB1
P35222
367
AR
P10275
direct interaction
11792709
1499
CTNNB1
P35222
367
AR
P10275
direct interaction
11792709
1499
CTNNB1
P35222
2309
FOXO3
O43524
physical association
15905404
1499
CTNNB1
P35222
999
CDH1
P12830
physical association
7954478
1499
CTNNB1
P35222
999
CDH1
P12830
physical association
11712088
1499
CTNNB1
P35222
6925
TCF4
P15884
association
11713475
1499
CTNNB1
P35222
2932
GSK3B
P49841
physical association
11251183
1499
CTNNB1
P35222
23411
SIRT1
Q96EB6
physical association
20439735
1499
CTNNB1
P35222
5295
PIK3R1
P27986
direct interaction
10477752
1499
CTNNB1
P35222
1500
CTNND1
O60716
physical association
9535896
1499
CTNNB1
P35222
324
APC
P25054
direct interaction
12628243
1499
CTNNB1
P35222
6925
TCF4
P15884
direct interaction
12657632
1499
CTNNB1
P35222
324
APC
P25054
physical association
11251183
1499
CTNNB1
P35222
324
APC
P25054
physical association
11533658
1499
CTNNB1
P35222
6925
TCF4
P15884
direct interaction
22080605
1499
CTNNB1
P35222
367
AR
P10275
physical association
12944908
1499
CTNNB1
P35222
367
AR
P10275
direct interaction
12944908
1499
CTNNB1
P35222
999
CDH1
P12830
physical association
16125672
1499
CTNNB1
P35222
324
APC
P25054
physical association
19576224
1499
CTNNB1
P35222
2932
GSK3B
P49841
physical association
19576224
1499
CTNNB1
P35222
324
APC
P25054
physical association
11712088
1499
CTNNB1
P35222
6925
TCF4
P15884
direct interaction
20126258
1499
CTNNB1
P35222
2064
ERBB2
P04626
direct interaction
7702605
1499
CTNNB1
P35222
2064
ERBB2
P04626
direct interaction
7702605
1499
CTNNB1
P35222
7048
TGFBR2
P37173
physical association
12000714
1499
CTNNB1
P35222
6925
TCF4
P15884
physical association
17072306
1499
CTNNB1
P35222
1500
CTNND1
O60716
physical association
11712088
1499
CTNNB1
P35222
8085
KMT2D
O14686
direct interaction
16510874
1499
CTNNB1
P35222
9759
HDAC4
P56524
physical association
16204248
1499
CTNNB1
P35222
2099
ESR1
P03372
physical association
15304487
1499
CTNNB1
P35222
2064
ERBB2
P04626
colocalization
11950845
1499
CTNNB1
P35222
2064
ERBB2
P04626
physical association
11950845
1499
CTNNB1
P35222
999
CDH1
P12830
physical association
15023525
1499
CTNNB1
P35222
999
CDH1
P12830
physical association
18593907
1499
CTNNB1
P35222
8085
KMT2D
O14686
direct interaction
16510875
1499
CTNNB1
P35222
999
CDH1
P12830
physical association
11113628
1499
CTNNB1
P35222
999
CDH1
P12830
physical association
12169098
1499
CTNNB1
P35222
5601
MAPK9
P45984
physical association
19667122
1499
CTNNB1
P35222
5599
MAPK8
P45983
physical association
19667122
1499
CTNNB1
P35222
4851
NOTCH1
P46531
physical association
19000719
1499
CTNNB1
P35222
4851
NOTCH1
P46531
direct interaction
19000719
1499
CTNNB1
P35222
999
CDH1
P12830
physical association
10772923
1500
CTNND1
O60716
1000
CDH2
P19022
physical association
20371349
1500
CTNND1
O60716
999
CDH1
P12830
direct interaction
12707304
1500
CTNND1
O60716
999
CDH1
P12830
physical association
12640114
1500
CTNND1
O60716
6714
SRC
P12931
physical association
12640114
1500
CTNND1
O60716
999
CDH1
P12830
physical association
10409703
1500
CTNND1
O60716
999
CDH1
P12830
direct interaction
10409703
1500
CTNND1
O60716
999
CDH1
P12830
physical association
12427869
1500
CTNND1
O60716
1001
CDH3
P22223
physical association
8660921
1500
CTNND1
O60716
999
CDH1
P12830
physical association
19711372
1500
CTNND1
O60716
999
CDH1
P12830
physical association
21670201
1500
CTNND1
O60716
999
CDH1
P12830
physical association
7876318
1514
CTSL
P07711
6256
RXRA
P19793
direct interaction
9837884
3576
CXCL8
P10145
3576
CXCL8
P10145
direct interaction
2184886
3576
CXCL8
P10145
3576
CXCL8
P10145
direct interaction
8077676
3576
CXCL8
P10145
2033
EP300
Q09472
physical association
11940655
3576
CXCL8
P10145
6382
SDC1
P18827
direct interaction
12902511
1634
DCN
P07585
1956
EGFR
P00533
direct interaction
12105206
1634
DCN
P07585
1291
COL6A1
P12109
direct interaction
1544908
1634
DCN
P07585
1956
EGFR
P00533
direct interaction
9988678
1634
DCN
P07585
1956
EGFR
P00533
direct interaction
12105206
1655
DDX5
P17844
1655
DDX5
P17844
physical association
19995069
1655
DDX5
P17844
2033
EP300
Q09472
physical association
19995069
1655
DDX5
P17844
2099
ESR1
P03372
physical association
19995069
1655
DDX5
P17844
2099
ESR1
P03372
physical association
10409727
1655
DDX5
P17844
2099
ESR1
P03372
direct interaction
10409727
1655
DDX5
P17844
2033
EP300
Q09472
physical association
12527917
8560
DEGS1
O15121
6566
SLC16A1
P53985
physical association
17353931
1718
DHCR24
Q15392
7157
TP53
P04637
physical association
15577914
56616
DIABLO
Q9NR28
329
BIRC2
Q13490
physical association
20957035
56616
DIABLO
Q9NR28
56616
DIABLO
Q9NR28
physical association
20957035
56616
DIABLO
Q9NR28
332
BIRC5
O15392
direct interaction
12660240
56616
DIABLO
Q9NR28
332
BIRC5
O15392
physical association
12660240
56616
DIABLO
Q9NR28
56616
DIABLO
Q9NR28
association
10972280
56616
DIABLO
Q9NR28
56616
DIABLO
Q9NR28
association
10972280
56616
DIABLO
Q9NR28
329
BIRC2
Q13490
physical association
16282325
56616
DIABLO
Q9NR28
332
BIRC5
O15392
physical association
15541727
56616
DIABLO
Q9NR28
329
BIRC2
Q13490
physical association
10929712
56616
DIABLO
Q9NR28
329
BIRC2
Q13490
physical association
12218061
9988
DMTF1
Q9Y222
7157
TP53
P04637
physical association
22331460
1785
DNM2
P50570
6714
SRC
P12931
direct interaction
15834155
1785
DNM2
P50570
3146
HMGB1
P09429
direct interaction
21900206
1786
DNMT1
P26358
1111
CHEK1
O14757
physical association
17991895
1786
DNMT1
P26358
5111
PCNA
P12004
direct interaction
12354094
1786
DNMT1
P26358
6667
SP1
P08047
physical association
17124180
1786
DNMT1
P26358
207
AKT1
P31749
physical association
21151116
1786
DNMT1
P26358
207
AKT1
P31749
direct interaction
21151116
1786
DNMT1
P26358
1869
E2F1
Q01094
colocalization
10888886
1786
DNMT1
P26358
5925
RB1
P06400
colocalization
10888886
1786
DNMT1
P26358
5111
PCNA
P12004
physical association
22606318
1786
DNMT1
P26358
5111
PCNA
P12004
direct interaction
22606318
1786
DNMT1
P26358
5111
PCNA
P12004
direct interaction
22606318
1786
DNMT1
P26358
5111
PCNA
P12004
physical association
20613874
1786
DNMT1
P26358
5925
RB1
P06400
physical association
11847125
1786
DNMT1
P26358
1111
CHEK1
O14757
physical association
20940144
1786
DNMT1
P26358
5111
PCNA
P12004
physical association
20940144
1786
DNMT1
P26358
6774
STAT3
P40763
physical association
15870198
1786
DNMT1
P26358
861
RUNX1
Q01196
direct interaction
15735013
1786
DNMT1
P26358
862
RUNX1T1
Q06455
direct interaction
15735013
1786
DNMT1
P26358
862
RUNX1T1
Q06455
colocalization
15735013
1786
DNMT1
P26358
861
RUNX1
Q01196
colocalization
15735013
1786
DNMT1
P26358
861
RUNX1
Q01196
physical association
15735013
1786
DNMT1
P26358
862
RUNX1T1
Q06455
physical association
15735013
1786
DNMT1
P26358
23411
SIRT1
Q96EB6
physical association
21947282
1786
DNMT1
P26358
1786
DNMT1
P26358
physical association
19173286
1843
DUSP1
P28562
5601
MAPK9
P45984
physical association
11359773
1843
DUSP1
P28562
5594
MAPK1
P28482
physical association
18519678
1843
DUSP1
P28562
5595
MAPK3
P27361
direct interaction
11278799
1843
DUSP1
P28562
5594
MAPK1
P28482
direct interaction
11278799
1843
DUSP1
P28562
5599
MAPK8
P45983
direct interaction
11278799
1843
DUSP1
P28562
1432
MAPK14
Q16539
direct interaction
11278799
1857
DVL3
Q92997
1499
CTNNB1
P35222
physical association
10806215
1857
DVL3
Q92997
83737
ITCH
Q96J02
physical association
22826439
1857
DVL3
Q92997
3104
ZBTB48
P10074
direct interaction
16189514
1869
E2F1
Q01094
6667
SP1
P08047
direct interaction
8657141
1869
E2F1
Q01094
5925
RB1
P06400
physical association
8230483
1869
E2F1
Q01094
5925
RB1
P06400
direct interaction
8230483
1869
E2F1
Q01094
2099
ESR1
P03372
physical association
22216287
1869
E2F1
Q01094
367
AR
P10275
physical association
22508987
1869
E2F1
Q01094
5925
RB1
P06400
physical association
9553123
1869
E2F1
Q01094
7158
TP53BP1
Q12888
physical association
8896460
1869
E2F1
Q01094
7158
TP53BP1
Q12888
direct interaction
8896460
1869
E2F1
Q01094
4193
MDM2
Q00987
physical association
16170383
1869
E2F1
Q01094
5925
RB1
P06400
physical association
22078878
1869
E2F1
Q01094
6667
SP1
P08047
direct interaction
8657142
1869
E2F1
Q01094
6667
SP1
P08047
physical association
8657142
1869
E2F1
Q01094
51433
ANAPC5
Q9UJX4
physical association
22580462
1869
E2F1
Q01094
5925
RB1
P06400
physical association
11839806
1869
E2F1
Q01094
1026
CDKN1A
P38936
colocalization
15964998
1869
E2F1
Q01094
2932
GSK3B
P49841
physical association
18367454
1869
E2F1
Q01094
5925
RB1
P06400
direct interaction
8346196
1869
E2F1
Q01094
5925
RB1
P06400
physical association
15485920
1869
E2F1
Q01094
5925
RB1
P06400
physical association
16766265
1869
E2F1
Q01094
6667
SP1
P08047
direct interaction
10547281
1869
E2F1
Q01094
6667
SP1
P08047
physical association
10547281
1869
E2F1
Q01094
5925
RB1
P06400
physical association
19477924
1869
E2F1
Q01094
1017
CDK2
P24941
direct interaction
7969176
1869
E2F1
Q01094
5925
RB1
P06400
physical association
17380128
1869
E2F1
Q01094
5925
RB1
P06400
colocalization
17380128
1869
E2F1
Q01094
329
BIRC2
Q13490
physical association
21653699
1869
E2F1
Q01094
4790
NFKB1
P19838
direct interaction
9368006
1871
E2F3
O00716
891
CCNB1
P14635
physical association
22157815
1871
E2F3
O00716
5111
PCNA
P12004
physical association
22157815
1871
E2F3
O00716
8085
KMT2D
O14686
physical association
16951254
1871
E2F3
O00716
5925
RB1
P06400
physical association
17380128
1894
ECT2
Q9H8V3
5590
PRKCZ
Q05513
physical association
15254234
1956
EGFR
P00533
2549
GAB1
Q13480
physical association
11432805
1956
EGFR
P00533
6464
SHC1
P29353
physical association
11408594
1956
EGFR
P00533
2064
ERBB2
P04626
physical association
11408594
1956
EGFR
P00533
10254
STAM2
O75886
physical association
17403676
1956
EGFR
P00533
6714
SRC
P12931
physical association
10971656
1956
EGFR
P00533
1051
CEBPB
P17676
physical association
12095417
1956
EGFR
P00533
2065
ERBB3
P21860
physical association
10527633
1956
EGFR
P00533
857
CAV1
Q03135
direct interaction
9374534
1956
EGFR
P00533
857
CAV1
Q03135
physical association
9374534
1956
EGFR
P00533
6464
SHC1
P29353
physical association
10595738
1956
EGFR
P00533
5111
PCNA
P12004
direct interaction
17115032
1956
EGFR
P00533
5111
PCNA
P12004
physical association
17115032
1956
EGFR
P00533
5578
PRKCA
P17252
physical association
12878187
1956
EGFR
P00533
5921
RASA1
P20936
direct interaction
8647858
1956
EGFR
P00533
2064
ERBB2
P04626
physical association
21044682
1956
EGFR
P00533
6464
SHC1
P29353
physical association
9130710
1956
EGFR
P00533
6464
SHC1
P29353
physical association
9756944
1956
EGFR
P00533
6774
STAT3
P40763
physical association
9756944
1956
EGFR
P00533
6464
SHC1
P29353
physical association
11370743
1956
EGFR
P00533
2064
ERBB2
P04626
physical association
16207817
1956
EGFR
P00533
5295
PIK3R1
P27986
physical association
21701776
1956
EGFR
P00533
3958
LGALS3
P17931
physical association
19225046
1956
EGFR
P00533
1956
EGFR
P00533
physical association
19225046
1956
EGFR
P00533
857
CAV1
Q03135
physical association
19446582
1956
EGFR
P00533
378
ARF4
P18085
direct interaction
12446727
1956
EGFR
P00533
378
ARF4
P18085
physical association
12446727
1956
EGFR
P00533
367
AR
P10275
physical association
15305378
1956
EGFR
P00533
367
AR
P10275
physical association
15288768
1956
EGFR
P00533
10254
STAM2
O75886
direct interaction
15212941
1956
EGFR
P00533
6464
SHC1
P29353
direct interaction
19531499
1956
EGFR
P00533
7534
YWHAZ
P63104
physical association
19531499
1956
EGFR
P00533
54206
ERRFI1
Q9UJM3
physical association
19531499
1956
EGFR
P00533
5295
PIK3R1
P27986
physical association
19531499
1956
EGFR
P00533
6464
SHC1
P29353
physical association
19531499
1956
EGFR
P00533
1499
CTNNB1
P35222
direct interaction
9535896
1956
EGFR
P00533
1500
CTNND1
O60716
direct interaction
9535896
1956
EGFR
P00533
10040
TOM1L1
O75674
physical association
19798056
1956
EGFR
P00533
857
CAV1
Q03135
physical association
16407214
1956
EGFR
P00533
9021
SOCS3
O14543
physical association
12070153
1956
EGFR
P00533
2064
ERBB2
P04626
physical association
17307140
1956
EGFR
P00533
2185
PTK2B
Q14289
physical association
10777553
1956
EGFR
P00533
6714
SRC
P12931
physical association
10777553
1956
EGFR
P00533
1499
CTNNB1
P35222
physical association
11950845
1956
EGFR
P00533
6774
STAT3
P40763
physical association
10358079
1956
EGFR
P00533
6464
SHC1
P29353
physical association
10049786
1956
EGFR
P00533
6464
SHC1
P29353
physical association
18271526
1956
EGFR
P00533
3716
JAK1
P23458
physical association
18271526
1956
EGFR
P00533
2549
GAB1
Q13480
physical association
18271526
1956
EGFR
P00533
54206
ERRFI1
Q9UJM3
physical association
18271526
1956
EGFR
P00533
983
CDK1
P06493
physical association
18271526
1956
EGFR
P00533
1956
EGFR
P00533
physical association
18271526
1956
EGFR
P00533
11047
ADRM1
Q16186
direct interaction
20029029
1956
EGFR
P00533
3303
HSPA1A
P0DMV8
direct interaction
20029029
1956
EGFR
P00533
2335
FN1
P02751
direct interaction
20029029
1956
EGFR
P00533
5782
PTPN12
Q05209
direct interaction
20029029
1956
EGFR
P00533
1173
AP2M1
Q96CW1
direct interaction
20029029
1956
EGFR
P00533
6774
STAT3
P40763
physical association
21573184
1956
EGFR
P00533
6714
SRC
P12931
physical association
21573184
1956
EGFR
P00533
6464
SHC1
P29353
physical association
9544989
1956
EGFR
P00533
1499
CTNNB1
P35222
physical association
9233779
1956
EGFR
P00533
1956
EGFR
P00533
physical association
14576349
1956
EGFR
P00533
6774
STAT3
P40763
colocalization
15950906
1956
EGFR
P00533
6774
STAT3
P40763
physical association
15950906
1956
EGFR
P00533
6774
STAT3
P40763
physical association
15485908
1956
EGFR
P00533
6776
STAT5A
P42229
physical association
16729043
1956
EGFR
P00533
6464
SHC1
P29353
physical association
16729043
1956
EGFR
P00533
6776
STAT5A
P42229
physical association
16729043
1956
EGFR
P00533
3084
NRG1
Q02297
physical association
7730382
1958
EGR1
P18146
6615
SNAI1
O95863
colocalization
20121949
1958
EGR1
P18146
6667
SP1
P08047
colocalization
20121949
1958
EGR1
P18146
5728
PTEN
P60484
physical association
21354147
1958
EGR1
P18146
1051
CEBPB
P17676
direct interaction
12947119
1958
EGR1
P18146
1051
CEBPB
P17676
direct interaction
12947119
5610
EIF2AK2
P19525
6774
STAT3
P40763
physical association
11350938
5610
EIF2AK2
P19525
5610
EIF2AK2
P19525
direct interaction
7568151
5610
EIF2AK2
P19525
5610
EIF2AK2
P19525
direct interaction
7568151
5610
EIF2AK2
P19525
5610
EIF2AK2
P19525
physical association
10848580
5610
EIF2AK2
P19525
7157
TP53
P04637
direct interaction
10348343
5610
EIF2AK2
P19525
7157
TP53
P04637
direct interaction
10348343
5610
EIF2AK2
P19525
7157
TP53
P04637
physical association
10348343
1977
EIF4E
P06730
1978
EIF4EBP1
Q13541
physical association
22586265
1977
EIF4E
P06730
1981
EIF4G1
Q04637
physical association
22586265
1977
EIF4E
P06730
1981
EIF4G1
Q04637
physical association
10600798
1977
EIF4E
P06730
1978
EIF4EBP1
Q13541
physical association
12588975
1977
EIF4E
P06730
1981
EIF4G1
Q04637
physical association
16720573
1977
EIF4E
P06730
1977
EIF4E
P06730
physical association
16648488
1977
EIF4E
P06730
1978
EIF4EBP1
Q13541
physical association
16648488
1977
EIF4E
P06730
1978
EIF4EBP1
Q13541
direct interaction
10364159
1977
EIF4E
P06730
1978
EIF4EBP1
Q13541
physical association
10698949
1977
EIF4E
P06730
1978
EIF4EBP1
Q13541
physical association
10753870
1977
EIF4E
P06730
1978
EIF4EBP1
Q13541
association
12071973
1977
EIF4E
P06730
1981
EIF4G1
Q04637
physical association
16648488
1977
EIF4E
P06730
1981
EIF4G1
Q04637
physical association
16541103
1977
EIF4E
P06730
1981
EIF4G1
Q04637
physical association
10753870
1977
EIF4E
P06730
1981
EIF4G1
Q04637
direct interaction
7651417
1977
EIF4E
P06730
1978
EIF4EBP1
Q13541
direct interaction
7651417
1977
EIF4E
P06730
1978
EIF4EBP1
Q13541
physical association
16824195
1977
EIF4E
P06730
1978
EIF4EBP1
Q13541
direct interaction
16189514
1978
EIF4EBP1
Q13541
1977
EIF4E
P06730
physical association
17353931
1978
EIF4EBP1
Q13541
1977
EIF4E
P06730
physical association
15767663
1978
EIF4EBP1
Q13541
57521
RPTOR
Q8N122
physical association
12912989
1978
EIF4EBP1
Q13541
57521
RPTOR
Q8N122
physical association
12747827
1978
EIF4EBP1
Q13541
57521
RPTOR
Q8N122
physical association
12150926
1978
EIF4EBP1
Q13541
57521
RPTOR
Q8N122
direct interaction
12150926
1978
EIF4EBP1
Q13541
57521
RPTOR
Q8N122
physical association
16798736
1978
EIF4EBP1
Q13541
57521
RPTOR
Q8N122
physical association
15767663
1978
EIF4EBP1
Q13541
57521
RPTOR
Q8N122
physical association
12604610
1978
EIF4EBP1
Q13541
57521
RPTOR
Q8N122
direct interaction
12912989
1978
EIF4EBP1
Q13541
1977
EIF4E
P06730
direct interaction
11605658
1978
EIF4EBP1
Q13541
57521
RPTOR
Q8N122
direct interaction
12912989
1978
EIF4EBP1
Q13541
1977
EIF4E
P06730
physical association
18957614
1978
EIF4EBP1
Q13541
1977
EIF4E
P06730
physical association
16798736
1978
EIF4EBP1
Q13541
1977
EIF4E
P06730
physical association
16242075
1978
EIF4EBP1
Q13541
1977
EIF4E
P06730
physical association
16824195
1978
EIF4EBP1
Q13541
1977
EIF4E
P06730
direct interaction
10405182
1978
EIF4EBP1
Q13541
2475
MTOR
P42345
physical association
12150926
1978
EIF4EBP1
Q13541
2475
MTOR
P42345
physical association
16798736
1978
EIF4EBP1
Q13541
2475
MTOR
P42345
physical association
15767663
1981
EIF4G1
Q04637
1977
EIF4E
P06730
physical association
16541103
1981
EIF4G1
Q04637
1977
EIF4E
P06730
physical association
16648488
1999
ELF3
P78545
3716
JAK1
P23458
physical association
17353931
1999
ELF3
P78545
4790
NFKB1
P19838
direct interaction
11036073
1999
ELF3
P78545
2064
ERBB2
P04626
suppressive genetic interaction defined by inequality
12242338
2033
EP300
Q09472
7157
TP53
P04637
direct interaction
17452980
2033
EP300
Q09472
7020
TFAP2A
P05549
direct interaction
12586840
2033
EP300
Q09472
1958
EGR1
P18146
direct interaction
9806899
2033
EP300
Q09472
7157
TP53
P04637
direct interaction
12690203
2033
EP300
Q09472
2033
EP300
Q09472
direct interaction
17065153
2033
EP300
Q09472
7157
TP53
P04637
direct interaction
19805293
2033
EP300
Q09472
7157
TP53
P04637
physical association
20234175
2033
EP300
Q09472
4193
MDM2
Q00987
physical association
20234175
2033
EP300
Q09472
1432
MAPK14
Q16539
direct interaction
21444723
2033
EP300
Q09472
4851
NOTCH1
P46531
physical association
19838210
2033
EP300
Q09472
2099
ESR1
P03372
physical association
19838210
2033
EP300
Q09472
4772
NFATC1
O95644
direct interaction
21413932
2033
EP300
Q09472
6776
STAT5A
P42229
direct interaction
9773981
2033
EP300
Q09472
6776
STAT5A
P42229
direct interaction
9773981
2033
EP300
Q09472
6776
STAT5A
P42229
physical association
9773981
2033
EP300
Q09472
5594
MAPK1
P28482
physical association
17623675
2033
EP300
Q09472
2033
EP300
Q09472
physical association
17510411
2033
EP300
Q09472
6659
SOX4
Q06945
physical association
19234109
2033
EP300
Q09472
7157
TP53
P04637
physical association
19234109
2033
EP300
Q09472
1017
CDK2
P24941
direct interaction
10330164
2033
EP300
Q09472
6667
SP1
P08047
physical association
17906698
2033
EP300
Q09472
6667
SP1
P08047
colocalization
17906698
2033
EP300
Q09472
7157
TP53
P04637
physical association
22266186
2033
EP300
Q09472
5562
PRKAA1
Q13131
direct interaction
22318606
2033
EP300
Q09472
7157
TP53
P04637
physical association
18612383
2033
EP300
Q09472
2099
ESR1
P03372
direct interaction
19887647
2033
EP300
Q09472
2099
ESR1
P03372
physical association
20388208
2033
EP300
Q09472
6095
RORA
P35398
direct interaction
9862959
2033
EP300
Q09472
2033
EP300
Q09472
direct interaction
10567538
2033
EP300
Q09472
4086
SMAD1
Q15797
physical association
10673036
2033
EP300
Q09472
3091
HIF1A
Q16665
association
11959990
2033
EP300
Q09472
3091
HIF1A
Q16665
physical association
11823643
2033
EP300
Q09472
3164
NR4A1
P22736
direct interaction
20438716
2033
EP300
Q09472
7157
TP53
P04637
physical association
18243116
2033
EP300
Q09472
3576
CXCL8
P10145
direct interaction
11940655
2033
EP300
Q09472
3576
CXCL8
P10145
physical association
11940655
2033
EP300
Q09472
7020
TFAP2A
P05549
physical association
12586840
2033
EP300
Q09472
7157
TP53
P04637
physical association
17977830
2033
EP300
Q09472
6774
STAT3
P40763
physical association
22116549
2033
EP300
Q09472
5468
PPARG
P37231
direct interaction
12479814
2033
EP300
Q09472
2099
ESR1
P03372
direct interaction
12479814
2033
EP300
Q09472
7157
TP53
P04637
direct interaction
18485870
2033
EP300
Q09472
2033
EP300
Q09472
direct interaction
22100894
2033
EP300
Q09472
4851
NOTCH1
P46531
direct interaction
22100894
2033
EP300
Q09472
4851
NOTCH1
P46531
direct interaction
22100894
2033
EP300
Q09472
51433
ANAPC5
Q9UJX4
physical association
16319895
2033
EP300
Q09472
999
CDH1
P12830
physical association
16319895
2033
EP300
Q09472
2099
ESR1
P03372
direct interaction
14761960
2033
EP300
Q09472
7157
TP53
P04637
direct interaction
12162806
2033
EP300
Q09472
6774
STAT3
P40763
physical association
11923478
2033
EP300
Q09472
2099
ESR1
P03372
physical association
12574227
2033
EP300
Q09472
5241
PGR
P06401
physical association
12574227
2033
EP300
Q09472
2099
ESR1
P03372
physical association
22227247
2033
EP300
Q09472
7157
TP53
P04637
direct interaction
16024799
2033
EP300
Q09472
8877
SPHK1
Q9NYA1
direct interaction
22227192
2033
EP300
Q09472
4790
NFKB1
P19838
physical association
20065107
2033
EP300
Q09472
3725
JUN
P05412
direct interaction
12437352
2033
EP300
Q09472
3725
JUN
P05412
colocalization
12437352
2033
EP300
Q09472
3725
JUN
P05412
association
12437352
2033
EP300
Q09472
10111
RAD50
Q92878
physical association
16051665
2033
EP300
Q09472
4683
NBN
O60934
physical association
16051665
2033
EP300
Q09472
7158
TP53BP1
Q12888
physical association
16051665
2033
EP300
Q09472
4361
MRE11A
P49959
physical association
16051665
2033
EP300
Q09472
4609
MYC
P01106
direct interaction
16287840
2033
EP300
Q09472
4609
MYC
P01106
physical association
16287840
2033
EP300
Q09472
4609
MYC
P01106
direct interaction
16126174
2033
EP300
Q09472
6667
SP1
P08047
physical association
12200149
2033
EP300
Q09472
5111
PCNA
P12004
physical association
12937166
2033
EP300
Q09472
5111
PCNA
P12004
direct interaction
12937166
2033
EP300
Q09472
3725
JUN
P05412
physical association
11980644
2033
EP300
Q09472
207
AKT1
P31749
physical association
20333651
2033
EP300
Q09472
4089
SMAD4
Q13485
physical association
10887155
2033
EP300
Q09472
1655
DDX5
P17844
physical association
12527917
2033
EP300
Q09472
7157
TP53
P04637
direct interaction
11782467
2033
EP300
Q09472
7157
TP53
P04637
direct interaction
11782467
2033
EP300
Q09472
7046
TGFBR1
P36897
physical association
21629263
2033
EP300
Q09472
4790
NFKB1
P19838
physical association
14662860
2033
EP300
Q09472
6774
STAT3
P40763
physical association
15653507
2033
EP300
Q09472
6774
STAT3
P40763
direct interaction
15653507
2033
EP300
Q09472
1958
EGR1
P18146
physical association
9806899
2033
EP300
Q09472
1958
EGR1
P18146
direct interaction
9806899
2033
EP300
Q09472
7428
VHL
P40337
physical association
16678111
2033
EP300
Q09472
4086
SMAD1
Q15797
physical association
10205054
2033
EP300
Q09472
6774
STAT3
P40763
physical association
10205054
2033
EP300
Q09472
7157
TP53
P04637
physical association
16678111
2033
EP300
Q09472
2099
ESR1
P03372
physical association
11782371
2033
EP300
Q09472
5111
PCNA
P12004
physical association
11268218
2033
EP300
Q09472
5111
PCNA
P12004
direct interaction
11268218
2033
EP300
Q09472
4193
MDM2
Q00987
direct interaction
9809062
2033
EP300
Q09472
7157
TP53
P04637
direct interaction
9809062
2033
EP300
Q09472
595
CCND1
P24385
direct interaction
11788592
2033
EP300
Q09472
7157
TP53
P04637
colocalization
9809062
2033
EP300
Q09472
4193
MDM2
Q00987
colocalization
9809062
2033
EP300
Q09472
1051
CEBPB
P17676
direct interaction
9343424
2033
EP300
Q09472
1051
CEBPB
P17676
physical association
9343424
2033
EP300
Q09472
7157
TP53
P04637
physical association
16537920
2033
EP300
Q09472
4790
NFKB1
P19838
direct interaction
11739381
2033
EP300
Q09472
864
RUNX3
Q13761
physical association
15138260
2033
EP300
Q09472
6667
SP1
P08047
direct interaction
16478997
2033
EP300
Q09472
5468
PPARG
P37231
physical association
17468099
2033
EP300
Q09472
4137
MAPT
P10636
direct interaction
20869593
2033
EP300
Q09472
5111
PCNA
P12004
direct interaction
18263614
2033
EP300
Q09472
2099
ESR1
P03372
direct interaction
16645043
2033
EP300
Q09472
5111
PCNA
P12004
physical association
18263614
2033
EP300
Q09472
6256
RXRA
P19793
physical association
17761950
2033
EP300
Q09472
7157
TP53
P04637
direct interaction
15337767
2033
EP300
Q09472
6198
RPS6KB1
P23443
direct interaction
19961954
2033
EP300
Q09472
6198
RPS6KB1
P23443
physical association
19961954
2033
EP300
Q09472
4086
SMAD1
Q15797
physical association
20851880
2033
EP300
Q09472
3091
HIF1A
Q16665
physical association
21148070
2033
EP300
Q09472
7157
TP53
P04637
physical association
15295102
2033
EP300
Q09472
4089
SMAD4
Q13485
physical association
18215124
2033
EP300
Q09472
4086
SMAD1
Q15797
physical association
16613856
2033
EP300
Q09472
4862
NPAS2
Q99743
direct interaction
14645221
2033
EP300
Q09472
4088
SMAD3
P84022
physical association
16876108
2033
EP300
Q09472
2309
FOXO3
O43524
physical association
19592618
2033
EP300
Q09472
7157
TP53
P04637
physical association
15542844
2033
EP300
Q09472
4088
SMAD3
P84022
physical association
15623506
2033
EP300
Q09472
6667
SP1
P08047
physical association
16734381
2033
EP300
Q09472
7157
TP53
P04637
direct interaction
17189186
2033
EP300
Q09472
2353
FOS
P01100
direct interaction
21937452
2033
EP300
Q09472
3725
JUN
P05412
direct interaction
21937452
2033
EP300
Q09472
8061
FOSL1
P15407
direct interaction
21937452
2033
EP300
Q09472
4193
MDM2
Q00987
direct interaction
15013777
2033
EP300
Q09472
4193
MDM2
Q00987
direct interaction
15154850
2033
EP300
Q09472
3091
HIF1A
Q16665
direct interaction
15154850
2033
EP300
Q09472
2597
GAPDH
P04406
physical association
18552833
2033
EP300
Q09472
3091
HIF1A
Q16665
physical association
19696166
2033
EP300
Q09472
3838
KPNA2
P52292
direct interaction
10801418
2033
EP300
Q09472
6667
SP1
P08047
direct interaction
10651903
2033
EP300
Q09472
6667
SP1
P08047
direct interaction
10651903
2064
ERBB2
P04626
2064
ERBB2
P04626
physical association
19077306
2064
ERBB2
P04626
5295
PIK3R1
P27986
physical association
9756944
2064
ERBB2
P04626
6464
SHC1
P29353
physical association
9756944
2064
ERBB2
P04626
1956
EGFR
P00533
physical association
17486068
2064
ERBB2
P04626
6464
SHC1
P29353
physical association
9710588
2064
ERBB2
P04626
2064
ERBB2
P04626
physical association
19060928
2064
ERBB2
P04626
2065
ERBB3
P21860
physical association
19060928
2064
ERBB2
P04626
1956
EGFR
P00533
physical association
19060928
2064
ERBB2
P04626
1499
CTNNB1
P35222
physical association
11245482
2064
ERBB2
P04626
1499
CTNNB1
P35222
physical association
11950845
2064
ERBB2
P04626
2065
ERBB3
P21860
physical association
15504738
2064
ERBB2
P04626
6774
STAT3
P40763
physical association
11940572
2064
ERBB2
P04626
2064
ERBB2
P04626
physical association
14576349
2064
ERBB2
P04626
6464
SHC1
P29353
physical association
16729043
2065
ERBB3
P21860
2064
ERBB2
P04626
physical association
9130710
2065
ERBB3
P21860
5295
PIK3R1
P27986
physical association
9130710
2065
ERBB3
P21860
5295
PIK3R1
P27986
physical association
9756944
2065
ERBB3
P21860
6464
SHC1
P29353
physical association
9756944
2065
ERBB3
P21860
3084
NRG1
Q02297
direct interaction
11555649
2065
ERBB3
P21860
4193
MDM2
Q00987
physical association
21930127
2065
ERBB3
P21860
1958
EGR1
P18146
direct interaction
12840049
2065
ERBB3
P21860
6464
SHC1
P29353
physical association
16729043
2065
ERBB3
P21860
5295
PIK3R1
P27986
physical association
11546794
2066
ERBB4
Q15303
6776
STAT5A
P42229
physical association
22584572
2066
ERBB4
Q15303
10413
YAP1
P46937
direct interaction
15023535
2066
ERBB4
Q15303
23118
TAB2
Q9NYJ8
physical association
17018285
2066
ERBB4
Q15303
23118
TAB2
Q9NYJ8
direct interaction
17018285
2066
ERBB4
Q15303
10413
YAP1
P46937
direct interaction
15023535
2066
ERBB4
Q15303
10413
YAP1
P46937
physical association
15023535
2066
ERBB4
Q15303
83737
ITCH
Q96J02
physical association
18334649
2066
ERBB4
Q15303
2064
ERBB2
P04626
physical association
10839362
2066
ERBB4
Q15303
7157
TP53
P04637
physical association
20858735
2066
ERBB4
Q15303
4193
MDM2
Q00987
physical association
20858735
2066
ERBB4
Q15303
10413
YAP1
P46937
direct interaction
12807903
2066
ERBB4
Q15303
10413
YAP1
P46937
colocalization
12807903
2066
ERBB4
Q15303
6776
STAT5A
P42229
physical association
16729043
2066
ERBB4
Q15303
6464
SHC1
P29353
physical association
16729043
2066
ERBB4
Q15303
6776
STAT5A
P42229
physical association
15534001
54206
ERRFI1
Q9UJM3
558
AXL
P30530
physical association
19815557
54206
ERRFI1
Q9UJM3
1956
EGFR
P00533
physical association
19815557
2099
ESR1
P03372
5295
PIK3R1
P27986
physical association
11689445
2099
ESR1
P03372
5241
PGR
P06401
physical association
22396492
2099
ESR1
P03372
688
KLF5
Q13887
physical association
19569049
2099
ESR1
P03372
2099
ESR1
P03372
direct interaction
12198596
2099
ESR1
P03372
1869
E2F1
Q01094
physical association
22216287
2099
ESR1
P03372
9759
HDAC4
P56524
direct interaction
19893013
2099
ESR1
P03372
1026
CDKN1A
P38936
direct interaction
17911387
2099
ESR1
P03372
5469
MED1
Q15648
physical association
12837248
2099
ESR1
P03372
208
AKT2
P31751
physical association
11507039
2099
ESR1
P03372
6714
SRC
P12931
physical association
17400812
2099
ESR1
P03372
5594
MAPK1
P28482
direct interaction
12093745
2099
ESR1
P03372
2033
EP300
Q09472
physical association
19887647
2099
ESR1
P03372
2099
ESR1
P03372
physical association
20353944
2099
ESR1
P03372
8085
KMT2D
O14686
physical association
21502505
2099
ESR1
P03372
23118
TAB2
Q9NYJ8
physical association
22249258
2099
ESR1
P03372
1051
CEBPB
P17676
direct interaction
7651415
2099
ESR1
P03372
2033
EP300
Q09472
direct interaction
12738788
2099
ESR1
P03372
1655
DDX5
P17844
direct interaction
12738788
2099
ESR1
P03372
5469
MED1
Q15648
direct interaction
12738788
2099
ESR1
P03372
5469
MED1
Q15648
direct interaction
12738788
2099
ESR1
P03372
6714
SRC
P12931
physical association
15020686
2099
ESR1
P03372
2064
ERBB2
P04626
physical association
15173068
2099
ESR1
P03372
8085
KMT2D
O14686
physical association
16603732
2099
ESR1
P03372
8085
KMT2D
O14686
physical association
16603732
2099
ESR1
P03372
1655
DDX5
P17844
physical association
20308691
2099
ESR1
P03372
60
ACTB
P60709
physical association
20308691
2099
ESR1
P03372
1655
DDX5
P17844
physical association
20308691
2099
ESR1
P03372
60
ACTB
P60709
physical association
20308691
2099
ESR1
P03372
2033
EP300
Q09472
direct interaction
12714702
2099
ESR1
P03372
2033
EP300
Q09472
direct interaction
12714702
2099
ESR1
P03372
595
CCND1
P24385
physical association
9039267
2099
ESR1
P03372
2100
ESR2
Q92731
physical association
9473491
2099
ESR1
P03372
9759
HDAC4
P56524
physical association
16051668
2099
ESR1
P03372
9759
HDAC4
P56524
direct interaction
16051668
2099
ESR1
P03372
6714
SRC
P12931
direct interaction
11013076
2099
ESR1
P03372
6667
SP1
P08047
physical association
15987735
2099
ESR1
P03372
6714
SRC
P12931
direct interaction
18451880
2099
ESR1
P03372
2099
ESR1
P03372
physical association
19117995
2099
ESR1
P03372
595
CCND1
P24385
direct interaction
16061635
2099
ESR1
P03372
3667
IRS1
P35568
physical association
12821935
2099
ESR1
P03372
23118
TAB2
Q9NYJ8
direct interaction
16469706
2099
ESR1
P03372
6714
SRC
P12931
direct interaction
10454579
2099
ESR1
P03372
23118
TAB2
Q9NYJ8
physical association
16469706
2099
ESR1
P03372
4193
MDM2
Q00987
physical association
12897156
2099
ESR1
P03372
1026
CDKN1A
P38936
physical association
12897156
2099
ESR1
P03372
2033
EP300
Q09472
direct interaction
11782371
2099
ESR1
P03372
2033
EP300
Q09472
physical association
11782371
2099
ESR1
P03372
2100
ESR2
Q92731
direct interaction
10706629
2099
ESR1
P03372
5469
MED1
Q15648
direct interaction
15886699
2099
ESR1
P03372
1655
DDX5
P17844
direct interaction
10409727
2099
ESR1
P03372
4609
MYC
P01106
physical association
16455494
2099
ESR1
P03372
1026
CDKN1A
P38936
direct interaction
15743834
2099
ESR1
P03372
4193
MDM2
Q00987
direct interaction
10766163
2099
ESR1
P03372
4193
MDM2
Q00987
physical association
17545634
2099
ESR1
P03372
4193
MDM2
Q00987
direct interaction
17545634
2099
ESR1
P03372
7157
TP53
P04637
physical association
17545634
2099
ESR1
P03372
1051
CEBPB
P17676
physical association
16651265
2099
ESR1
P03372
6667
SP1
P08047
physical association
16651265
2099
ESR1
P03372
6464
SHC1
P29353
direct interaction
11773443
2099
ESR1
P03372
5590
PRKCZ
Q05513
physical association
18313384
2099
ESR1
P03372
5469
MED1
Q15648
physical association
11867769
2099
ESR1
P03372
4193
MDM2
Q00987
direct interaction
11178989
2099
ESR1
P03372
2099
ESR1
P03372
direct interaction
12554772
2099
ESR1
P03372
2033
EP300
Q09472
physical association
18765668
2099
ESR1
P03372
6667
SP1
P08047
physical association
18765668
2099
ESR1
P03372
857
CAV1
Q03135
direct interaction
11563984
2099
ESR1
P03372
857
CAV1
Q03135
physical association
11563984
2099
ESR1
P03372
2100
ESR2
Q92731
physical association
19746436
2099
ESR1
P03372
6714
SRC
P12931
direct interaction
12630920
2099
ESR1
P03372
2100
ESR2
Q92731
direct interaction
12630920
2099
ESR1
P03372
6667
SP1
P08047
physical association
15557281
2099
ESR1
P03372
7520
XRCC5
P13010
physical association
16794079
2099
ESR1
P03372
6714
SRC
P12931
direct interaction
15604093
2099
ESR1
P03372
1655
DDX5
P17844
direct interaction
11250900
2099
ESR1
P03372
1655
DDX5
P17844
physical association
11250900
2099
ESR1
P03372
1655
DDX5
P17844
additive genetic interaction defined by inequality
11250900
2099
ESR1
P03372
7329
UBE2I
P63279
direct interaction
15666801
2099
ESR1
P03372
2033
EP300
Q09472
direct interaction
11867769
2099
ESR1
P03372
6774
STAT3
P40763
physical association
11429412
2099
ESR1
P03372
5469
MED1
Q15648
direct interaction
11867769
2099
ESR1
P03372
2033
EP300
Q09472
physical association
11867769
2099
ESR1
P03372
5469
MED1
Q15648
direct interaction
10770935
2099
ESR1
P03372
5469
MED1
Q15648
physical association
10770935
2099
ESR1
P03372
5469
MED1
Q15648
direct interaction
10760302
2099
ESR1
P03372
5469
MED1
Q15648
direct interaction
10760302
2100
ESR2
Q92731
2100
ESR2
Q92731
physical association
20353944
2100
ESR2
Q92731
2099
ESR1
P03372
direct interaction
9473491
2100
ESR2
Q92731
2099
ESR1
P03372
physical association
9473491
2100
ESR2
Q92731
6714
SRC
P12931
direct interaction
11013076
2100
ESR2
Q92731
5469
MED1
Q15648
direct interaction
11500849
2100
ESR2
Q92731
2033
EP300
Q09472
direct interaction
11500849
2100
ESR2
Q92731
4193
MDM2
Q00987
physical association
22349818
2100
ESR2
Q92731
2033
EP300
Q09472
physical association
18765668
2100
ESR2
Q92731
6667
SP1
P08047
physical association
18765668
2100
ESR2
Q92731
6714
SRC
P12931
direct interaction
12630920
2100
ESR2
Q92731
688
KLF5
Q13887
physical association
21487105
2100
ESR2
Q92731
688
KLF5
Q13887
direct interaction
21487105
2100
ESR2
Q92731
6714
SRC
P12931
direct interaction
15604093
2100
ESR2
Q92731
1655
DDX5
P17844
direct interaction
11250900
2100
ESR2
Q92731
5469
MED1
Q15648
direct interaction
11867769
2100
ESR2
Q92731
5469
MED1
Q15648
direct interaction
10770935
355
FAS
P25445
355
FAS
P25445
direct interaction
8940097
355
FAS
P25445
7329
UBE2I
P63279
direct interaction
8940097
355
FAS
P25445
355
FAS
P25445
direct interaction
7538908
355
FAS
P25445
7187
TRAF3
Q13114
direct interaction
7859281
355
FAS
P25445
7329
UBE2I
P63279
physical association
9257699
355
FAS
P25445
637
BID
P55957
association
15659383
355
FAS
P25445
5599
MAPK8
P45983
association
15659383
355
FAS
P25445
387
RHOA
P61586
association
15659383
2194
FASN
P49327
2194
FASN
P49327
direct interaction
11248039
2203
FBP1
P09467
2203
FBP1
P09467
association
2164670
2203
FBP1
P09467
2203
FBP1
P09467
direct interaction
16189514
2203
FBP1
P09467
2203
FBP1
P09467
direct interaction
16169070
55294
FBXW7
Q969H0
898
CCNE1
P24864
direct interaction
16338364
55294
FBXW7
Q969H0
6790
AURKA
O14965
physical association
19111882
55294
FBXW7
Q969H0
898
CCNE1
P24864
physical association
15980150
55294
FBXW7
Q969H0
2932
GSK3B
P49841
physical association
22513362
55294
FBXW7
Q969H0
6790
AURKA
O14965
physical association
22513362
55294
FBXW7
Q969H0
55294
FBXW7
Q969H0
physical association
17298674
55294
FBXW7
Q969H0
898
CCNE1
P24864
physical association
17298674
55294
FBXW7
Q969H0
688
KLF5
Q13887
physical association
20388706
55294
FBXW7
Q969H0
688
KLF5
Q13887
direct interaction
20388706
55294
FBXW7
Q969H0
688
KLF5
Q13887
physical association
20484041
55294
FBXW7
Q969H0
688
KLF5
Q13887
direct interaction
20484041
55294
FBXW7
Q969H0
55294
FBXW7
Q969H0
physical association
21620836
55294
FBXW7
Q969H0
4609
MYC
P01106
physical association
17646408
55294
FBXW7
Q969H0
898
CCNE1
P24864
physical association
17646408
55294
FBXW7
Q969H0
4851
NOTCH1
P46531
physical association
17646408
55294
FBXW7
Q969H0
55294
FBXW7
Q969H0
physical association
22608923
55294
FBXW7
Q969H0
4851
NOTCH1
P46531
physical association
17646409
55294
FBXW7
Q969H0
2475
MTOR
P42345
physical association
18787170
55294
FBXW7
Q969H0
55294
FBXW7
Q969H0
physical association
17189384
55294
FBXW7
Q969H0
898
CCNE1
P24864
direct interaction
16818231
55294
FBXW7
Q969H0
4609
MYC
P01106
physical association
15150404
55294
FBXW7
Q969H0
4609
MYC
P01106
direct interaction
15103331
55294
FBXW7
Q969H0
9134
CCNE2
O96020
direct interaction
19084516
55294
FBXW7
Q969H0
4609
MYC
P01106
physical association
15498494
55294
FBXW7
Q969H0
898
CCNE1
P24864
direct interaction
11565034
55294
FBXW7
Q969H0
898
CCNE1
P24864
physical association
11565034
55294
FBXW7
Q969H0
898
CCNE1
P24864
physical association
18559665
55294
FBXW7
Q969H0
4609
MYC
P01106
direct interaction
20848231
55294
FBXW7
Q969H0
898
CCNE1
P24864
physical association
15364936
55294
FBXW7
Q969H0
898
CCNE1
P24864
physical association
22388891
55294
FBXW7
Q969H0
4851
NOTCH1
P46531
physical association
22388891
55294
FBXW7
Q969H0
898
CCNE1
P24864
association
17434132
55294
FBXW7
Q969H0
898
CCNE1
P24864
physical association
17434132
55294
FBXW7
Q969H0
898
CCNE1
P24864
direct interaction
14536078
2243
FGA
P02671
2243
FGA
P02671
association
9689040
2243
FGA
P02671
2244
FGB
P02675
association
12356313
2246
FGF1
P05230
2246
FGF1
P05230
association
9655399
2246
FGF1
P05230
2260
FGFR1
P11362
association
11030354
2247
FGF2
P09038
7057
THBS1
P07996
direct interaction
17996481
2247
FGF2
P09038
6223
RPS19
P39019
association
11716516
2247
FGF2
P09038
6223
RPS19
P39019
direct interaction
11716516
2247
FGF2
P09038
6382
SDC1
P18827
association
16982797
2260
FGFR1
P11362
2247
FGF2
P09038
direct interaction
10950949
2260
FGFR1
P11362
2260
FGFR1
P11362
direct interaction
11030354
2260
FGFR1
P11362
2246
FGF1
P05230
direct interaction
8576175
2260
FGFR1
P11362
6774
STAT3
P40763
physical association
20388777
2260
FGFR1
P11362
6714
SRC
P12931
physical association
20388777
2260
FGFR1
P11362
6774
STAT3
P40763
physical association
20388777
2261
FGFR3
P22607
2246
FGF1
P05230
direct interaction
10574949
2261
FGFR3
P22607
2246
FGF1
P05230
direct interaction
8576175
2261
FGFR3
P22607
1513
CTSK
P43235
direct interaction
16169070
2266
FGG
P02679
2266
FGG
P02679
association
12501189
2266
FGG
P02679
2266
FGG
P02679
association
9333233
2266
FGG
P02679
2243
FGA
P02671
association
12356313
2266
FGG
P02679
2244
FGB
P02675
association
12356313
2272
FHIT
P49789
2272
FHIT
P49789
direct interaction
16189514
2272
FHIT
P49789
7329
UBE2I
P63279
direct interaction
11085938
2272
FHIT
P49789
7329
UBE2I
P63279
physical association
11085938
2277
FIGF
O43915
3791
KDR
P35968
direct interaction
9435229
2335
FN1
P02751
1294
COL7A1
Q02388
direct interaction
7963647
2335
FN1
P02751
7045
TGFBI
Q15582
direct interaction
11867580
2335
FN1
P02751
1401
CRP
P02741
direct interaction
6693419
2335
FN1
P02751
3371
TNC
P24821
direct interaction
7499434
2335
FN1
P02751
3371
TNC
P24821
physical association
7499434
2335
FN1
P02751
3678
ITGA5
P08648
direct interaction
1532572
2353
FOS
P01100
3725
JUN
P05412
direct interaction
9160889
2353
FOS
P01100
2099
ESR1
P03372
physical association
17317669
2353
FOS
P01100
3725
JUN
P05412
physical association
20410304
2353
FOS
P01100
3725
JUN
P05412
physical association
16055710
2353
FOS
P01100
4088
SMAD3
P84022
physical association
21829441
2353
FOS
P01100
3725
JUN
P05412
direct interaction
11053448
2353
FOS
P01100
3725
JUN
P05412
direct interaction
16714286
2353
FOS
P01100
3725
JUN
P05412
direct interaction
8380166
2353
FOS
P01100
3725
JUN
P05412
direct interaction
9872330
2353
FOS
P01100
5594
MAPK1
P28482
physical association
11431474
8061
FOSL1
P15407
3725
JUN
P05412
direct interaction
9160889
8061
FOSL1
P15407
2033
EP300
Q09472
physical association
17882273
8061
FOSL1
P15407
3725
JUN
P05412
physical association
11431474
3169
FOXA1
P55317
367
AR
P10275
direct interaction
12750453
3169
FOXA1
P55317
367
AR
P10275
physical association
12750453
2305
FOXM1
Q08050
999
CDH1
P12830
physical association
18758239
2309
FOXO3
O43524
1499
CTNNB1
P35222
physical association
15905404
2309
FOXO3
O43524
7529
YWHAB
P31946
physical association
20562859
2309
FOXO3
O43524
7531
YWHAE
P62258
physical association
20562859
2309
FOXO3
O43524
4088
SMAD3
P84022
physical association
21532621
2309
FOXO3
O43524
4089
SMAD4
Q13485
physical association
21532621
2309
FOXO3
O43524
5594
MAPK1
P28482
physical association
18204439
2309
FOXO3
O43524
4193
MDM2
Q00987
physical association
18204439
2309
FOXO3
O43524
4193
MDM2
Q00987
physical association
19321440
2309
FOXO3
O43524
7529
YWHAB
P31946
physical association
19940129
2309
FOXO3
O43524
4089
SMAD4
Q13485
physical association
15084259
2309
FOXO3
O43524
2033
EP300
Q09472
physical association
19592618
2309
FOXO3
O43524
472
ATM
Q13315
physical association
18344987
2309
FOXO3
O43524
472
ATM
Q13315
direct interaction
18344987
2309
FOXO3
O43524
23411
SIRT1
Q96EB6
physical association
20733005
2309
FOXO3
O43524
23411
SIRT1
Q96EB6
physical association
15126506
2549
GAB1
Q13480
6464
SHC1
P29353
physical association
9804835
2549
GAB1
Q13480
5295
PIK3R1
P27986
physical association
9804835
2549
GAB1
Q13480
6464
SHC1
P29353
direct interaction
9804835
2549
GAB1
Q13480
5295
PIK3R1
P27986
direct interaction
9804835
2549
GAB1
Q13480
5295
PIK3R1
P27986
physical association
8596638
2549
GAB1
Q13480
5295
PIK3R1
P27986
direct interaction
8596638
2549
GAB1
Q13480
4233
MET
P08581
physical association
9242692
2549
GAB1
Q13480
708
C1QBP
Q07021
physical association
10747014
2549
GAB1
Q13480
4233
MET
P08581
physical association
10871282
9846
GAB2
Q9UQC2
5295
PIK3R1
P27986
physical association
11334882
9846
GAB2
Q9UQC2
5295
PIK3R1
P27986
direct interaction
11334882
9846
GAB2
Q9UQC2
6464
SHC1
P29353
physical association
11782427
9846
GAB2
Q9UQC2
5295
PIK3R1
P27986
physical association
11782427
9846
GAB2
Q9UQC2
207
AKT1
P31749
physical association
11782427
9846
GAB2
Q9UQC2
5295
PIK3R1
P27986
physical association
10871282
9846
GAB2
Q9UQC2
4233
MET
P08581
physical association
10871282
2597
GAPDH
P04406
891
CCNB1
P14635
physical association
16474839
2597
GAPDH
P04406
891
CCNB1
P14635
direct interaction
16474839
2597
GAPDH
P04406
367
AR
P10275
direct interaction
8872471
2597
GAPDH
P04406
6310
ATXN1
P54253
direct interaction
8872471
2597
GAPDH
P04406
367
AR
P10275
direct interaction
8872471
2597
GAPDH
P04406
6310
ATXN1
P54253
direct interaction
8872471
2597
GAPDH
P04406
2597
GAPDH
P04406
association
16510976
2597
GAPDH
P04406
7531
YWHAE
P62258
direct interaction
21900206
2597
GAPDH
P04406
2033
EP300
Q09472
physical association
18552833
2621
GAS6
Q14393
558
AXL
P30530
direct interaction
8939948
2625
GATA3
P23771
4193
MDM2
Q00987
physical association
15975924
2625
GATA3
P23771
9759
HDAC4
P56524
physical association
16922677
2627
GATA6
Q92908
6667
SP1
P08047
physical association
14988427
2627
GATA6
Q92908
2033
EP300
Q09472
physical association
10851229
2627
GATA6
Q92908
6667
SP1
P08047
physical association
21076612
2697
GJA1
P17302
2697
GJA1
P17302
colocalization
11739633
2697
GJA1
P17302
857
CAV1
Q03135
colocalization
11980479
2697
GJA1
P17302
857
CAV1
Q03135
physical association
11980479
2903
GRIN2A
Q12879
6714
SRC
P12931
direct interaction
10458595
2903
GRIN2A
Q12879
6714
SRC
P12931
physical association
10458595
2903
GRIN2A
Q12879
2185
PTK2B
Q14289
physical association
12576483
2903
GRIN2A
Q12879
2185
PTK2B
Q14289
physical association
11478920
2931
GSK3A
P49840
4137
MAPT
P10636
direct interaction
9735171
2931
GSK3A
P49840
367
AR
P10275
physical association
15361837
2931
GSK3A
P49840
4137
MAPT
P10636
direct interaction
7931292
2931
GSK3A
P49840
4609
MYC
P01106
physical association
14563837
2932
GSK3B
P49841
208
AKT2
P31751
association
12434148
2932
GSK3B
P49841
4851
NOTCH1
P46531
direct interaction
12123574
2932
GSK3B
P49841
7157
TP53
P04637
physical association
12048243
2932
GSK3B
P49841
7157
TP53
P04637
additive genetic interaction defined by inequality
12048243
2932
GSK3B
P49841
2932
GSK3B
P49841
direct interaction
11835406
2932
GSK3B
P49841
1499
CTNNB1
P35222
physical association
11835406
2932
GSK3B
P49841
329
BIRC2
Q13490
physical association
19698783
2932
GSK3B
P49841
4853
NOTCH2
Q04721
direct interaction
12794074
2932
GSK3B
P49841
4853
NOTCH2
Q04721
physical association
12794074
2932
GSK3B
P49841
4137
MAPT
P10636
direct interaction
9771888
2932
GSK3B
P49841
1499
CTNNB1
P35222
physical association
10228155
2932
GSK3B
P49841
4137
MAPT
P10636
physical association
22965877
2932
GSK3B
P49841
4904
YBX1
P67809
direct interaction
16198352
2932
GSK3B
P49841
7248
TSC1
Q92574
physical association
12511557
2932
GSK3B
P49841
7249
TSC2
P49815
direct interaction
16959574
2932
GSK3B
P49841
7249
TSC2
P49815
physical association
12511557
2932
GSK3B
P49841
688
KLF5
Q13887
direct interaction
20484041
2932
GSK3B
P49841
1499
CTNNB1
P35222
direct interaction
19061640
2932
GSK3B
P49841
4137
MAPT
P10636
direct interaction
14612456
2932
GSK3B
P49841
1499
CTNNB1
P35222
direct interaction
10074433
2932
GSK3B
P49841
4790
NFKB1
P19838
direct interaction
11425860
2932
GSK3B
P49841
324
APC
P25054
physical association
11251183
2932
GSK3B
P49841
4088
SMAD3
P84022
physical association
18172167
2932
GSK3B
P49841
4137
MAPT
P10636
direct interaction
10090741
2932
GSK3B
P49841
367
AR
P10275
direct interaction
15178691
2932
GSK3B
P49841
367
AR
P10275
physical association
15178691
2932
GSK3B
P49841
1499
CTNNB1
P35222
direct interaction
10330181
2932
GSK3B
P49841
1051
CEBPB
P17676
physical association
20110283
2932
GSK3B
P49841
4609
MYC
P01106
physical association
14563837
2932
GSK3B
P49841
2932
GSK3B
P49841
direct interaction
21985244
2932
GSK3B
P49841
4137
MAPT
P10636
direct interaction
21985244
2932
GSK3B
P49841
2597
GAPDH
P04406
direct interaction
21900206
2932
GSK3B
P49841
1786
DNMT1
P26358
direct interaction
21900206
2932
GSK3B
P49841
10974
ADIRF
Q15847
direct interaction
21900206
2932
GSK3B
P49841
2475
MTOR
P42345
direct interaction
21900206
2932
GSK3B
P49841
7157
TP53
P04637
direct interaction
21900206
2932
GSK3B
P49841
6256
RXRA
P19793
direct interaction
21900206
2932
GSK3B
P49841
1978
EIF4EBP1
Q13541
direct interaction
21900206
2932
GSK3B
P49841
4193
MDM2
Q00987
direct interaction
16055726
2932
GSK3B
P49841
4193
MDM2
Q00987
physical association
16055726
2932
GSK3B
P49841
6615
SNAI1
O95863
direct interaction
15448698
2932
GSK3B
P49841
6615
SNAI1
O95863
physical association
15448698
2932
GSK3B
P49841
1499
CTNNB1
P35222
direct interaction
16039586
2932
GSK3B
P49841
5594
MAPK1
P28482
direct interaction
16039586
2932
GSK3B
P49841
4137
MAPT
P10636
direct interaction
9546672
2932
GSK3B
P49841
4088
SMAD3
P84022
physical association
21310903
2932
GSK3B
P49841
4780
NFE2L2
Q16236
direct interaction
22751928
2932
GSK3B
P49841
898
CCNE1
P24864
direct interaction
14536078
9464
HAND2
P61296
9464
HAND2
P61296
direct interaction
11812799
9464
HAND2
P61296
2033
EP300
Q09472
direct interaction
11994297
9759
HDAC4
P56524
7158
TP53BP1
Q12888
additive genetic interaction defined by inequality
22318606
9759
HDAC4
P56524
7157
TP53
P04637
additive genetic interaction defined by inequality
22318606
9759
HDAC4
P56524
7058
THBS2
P35442
additive genetic interaction defined by inequality
22318606
9759
HDAC4
P56524
864
RUNX3
Q13761
additive genetic interaction defined by inequality
22318606
9759
HDAC4
P56524
5728
PTEN
P60484
additive genetic interaction defined by inequality
22318606
9759
HDAC4
P56524
5347
PLK1
P53350
additive genetic interaction defined by inequality
22318606
9759
HDAC4
P56524
4638
MYLK
Q15746
additive genetic interaction defined by inequality
22318606
9759
HDAC4
P56524
4204
MECP2
P51608
additive genetic interaction defined by inequality
22318606
9759
HDAC4
P56524
3725
JUN
P05412
additive genetic interaction defined by inequality
22318606
9759
HDAC4
P56524
3339
HSPG2
P98160
additive genetic interaction defined by inequality
22318606
9759
HDAC4
P56524
1977
EIF4E
P06730
additive genetic interaction defined by inequality
22318606
9759
HDAC4
P56524
440
ASNS
P08243
additive genetic interaction defined by inequality
22318606
9759
HDAC4
P56524
4772
NFATC1
O95644
physical association
19218564
9759
HDAC4
P56524
6310
ATXN1
P54253
physical association
17646162
9759
HDAC4
P56524
367
AR
P10275
direct interaction
21242980
9759
HDAC4
P56524
367
AR
P10275
direct interaction
21242980
9759
HDAC4
P56524
367
AR
P10275
physical association
21242980
9759
HDAC4
P56524
3091
HIF1A
Q16665
direct interaction
19071119
9759
HDAC4
P56524
7531
YWHAE
P62258
physical association
10869435
9759
HDAC4
P56524
7529
YWHAB
P31946
physical association
10869435
9759
HDAC4
P56524
9759
HDAC4
P56524
direct interaction
11486037
9759
HDAC4
P56524
4790
NFKB1
P19838
physical association
12917325
9759
HDAC4
P56524
7158
TP53BP1
Q12888
physical association
12668657
9759
HDAC4
P56524
7329
UBE2I
P63279
direct interaction
16166628
9759
HDAC4
P56524
2099
ESR1
P03372
physical association
16051668
9759
HDAC4
P56524
2099
ESR1
P03372
direct interaction
16051668
9759
HDAC4
P56524
5595
MAPK3
P27361
physical association
11114188
9759
HDAC4
P56524
5594
MAPK1
P28482
physical association
11114188
9759
HDAC4
P56524
9759
HDAC4
P56524
physical association
18332106
9759
HDAC4
P56524
3091
HIF1A
Q16665
physical association
21148070
9759
HDAC4
P56524
6667
SP1
P08047
physical association
18850004
9759
HDAC4
P56524
3091
HIF1A
Q16665
physical association
16951198
9759
HDAC4
P56524
7529
YWHAB
P31946
physical association
10958686
3082
HGF
P14210
4233
MET
P08581
physical association
1655405
3082
HGF
P14210
3082
HGF
P14210
association
11597998
3090
HIC1
Q14526
23411
SIRT1
Q96EB6
physical association
16269335
3090
HIC1
Q14526
23411
SIRT1
Q96EB6
physical association
22510409
3090
HIC1
Q14526
3090
HIC1
Q14526
direct interaction
10611298
3090
HIC1
Q14526
9759
HDAC4
P56524
physical association
17283066
3090
HIC1
Q14526
23411
SIRT1
Q96EB6
physical association
17283066
3090
HIC1
Q14526
8289
ARID1A
O14497
direct interaction
19486893
3090
HIC1
Q14526
8289
ARID1A
O14497
physical association
19486893
3090
HIC1
Q14526
6925
TCF4
P15884
physical association
16724116
3090
HIC1
Q14526
6925
TCF4
P15884
direct interaction
16724116
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
21332579
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
12682018
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
11226425
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
11865071
3091
HIF1A
Q16665
2033
EP300
Q09472
physical association
11940656
3091
HIF1A
Q16665
7428
VHL
P40337
direct interaction
11504942
3091
HIF1A
Q16665
7428
VHL
P40337
direct interaction
15082527
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
18222538
3091
HIF1A
Q16665
7157
TP53
P04637
physical association
9537326
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
22932900
3091
HIF1A
Q16665
9759
HDAC4
P56524
physical association
19071119
3091
HIF1A
Q16665
596
BCL2
P10415
physical association
20668552
3091
HIF1A
Q16665
7428
VHL
P40337
direct interaction
11641274
3091
HIF1A
Q16665
7428
VHL
P40337
direct interaction
19147576
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
20724477
3091
HIF1A
Q16665
7428
VHL
P40337
direct interaction
17558023
3091
HIF1A
Q16665
7428
VHL
P40337
direct interaction
10878807
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
10973499
3091
HIF1A
Q16665
7157
TP53
P04637
physical association
12606552
3091
HIF1A
Q16665
4193
MDM2
Q00987
physical association
12606552
3091
HIF1A
Q16665
55294
FBXW7
Q969H0
physical association
21964756
3091
HIF1A
Q16665
7428
VHL
P40337
direct interaction
17981124
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
17973296
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
10353251
3091
HIF1A
Q16665
2033
EP300
Q09472
physical association
19940151
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
19940151
3091
HIF1A
Q16665
2033
EP300
Q09472
direct interaction
12778114
3091
HIF1A
Q16665
7428
VHL
P40337
direct interaction
21335603
3091
HIF1A
Q16665
6774
STAT3
P40763
physical association
18985005
3091
HIF1A
Q16665
7157
TP53
P04637
direct interaction
12124396
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
18985005
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
16611863
3091
HIF1A
Q16665
2033
EP300
Q09472
physical association
14691445
3091
HIF1A
Q16665
7428
VHL
P40337
direct interaction
22351759
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
22351759
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
18694926
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
14600153
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
12205091
3091
HIF1A
Q16665
3164
NR4A1
P22736
physical association
18305400
3091
HIF1A
Q16665
7428
VHL
P40337
direct interaction
18426857
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
12925778
3091
HIF1A
Q16665
7428
VHL
P40337
direct interaction
18264140
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
17132228
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
12586829
3091
HIF1A
Q16665
7428
VHL
P40337
direct interaction
12586829
3091
HIF1A
Q16665
7428
VHL
P40337
direct interaction
19123984
3091
HIF1A
Q16665
7428
VHL
P40337
direct interaction
19123984
3091
HIF1A
Q16665
7428
VHL
P40337
physical association
16140212
3091
HIF1A
Q16665
7428
VHL
P40337
direct interaction
16140212
3091
HIF1A
Q16665
7428
VHL
P40337
direct interaction
15721254
3091
HIF1A
Q16665
4609
MYC
P01106
physical association
15071503
3091
HIF1A
Q16665
4193
MDM2
Q00987
direct interaction
19696166
3091
HIF1A
Q16665
4193
MDM2
Q00987
physical association
19696166
3091
HIF1A
Q16665
4193
MDM2
Q00987
direct interaction
19696166
3091
HIF1A
Q16665
2033
EP300
Q09472
physical association
19696166
3091
HIF1A
Q16665
2033
EP300
Q09472
direct interaction
19696166
3091
HIF1A
Q16665
3725
JUN
P05412
physical association
19738058
8091
HMGA2
P52926
4790
NFKB1
P19838
direct interaction
12693954
8091
HMGA2
P52926
4790
NFKB1
P19838
direct interaction
12693954
8091
HMGA2
P52926
4086
SMAD1
Q15797
physical association
18425117
3146
HMGB1
P09429
7157
TP53
P04637
physical association
11106654
3146
HMGB1
P09429
7157
TP53
P04637
direct interaction
11106654
3174
HNF4G
Q14541
2597
GAPDH
P04406
direct interaction
15604093
3174
HNF4G
Q14541
6714
SRC
P12931
direct interaction
15604093
3265
HRAS
P01112
5894
RAF1
P04049
direct interaction
10783161
3265
HRAS
P01112
5290
PIK3CA
P42336
direct interaction
10783161
3265
HRAS
P01112
5894
RAF1
P04049
direct interaction
10783161
3265
HRAS
P01112
5894
RAF1
P04049
direct interaction
10369681
3265
HRAS
P01112
7157
TP53
P04637
physical association
21041410
3265
HRAS
P01112
5894
RAF1
P04049
physical association
12379659
3265
HRAS
P01112
5894
RAF1
P04049
direct interaction
7862125
3265
HRAS
P01112
673
BRAF
P15056
direct interaction
7706312
3265
HRAS
P01112
5604
MAP2K1
Q02750
physical association
7969158
3265
HRAS
P01112
5894
RAF1
P04049
direct interaction
7969158
3265
HRAS
P01112
5894
RAF1
P04049
direct interaction
9523700
3265
HRAS
P01112
5894
RAF1
P04049
direct interaction
9154803
3265
HRAS
P01112
673
BRAF
P15056
direct interaction
9154803
3265
HRAS
P01112
5894
RAF1
P04049
direct interaction
9154803
3265
HRAS
P01112
5894
RAF1
P04049
physical association
16803888
3265
HRAS
P01112
5894
RAF1
P04049
direct interaction
8628317
3265
HRAS
P01112
5894
RAF1
P04049
direct interaction
10922060
3303
HSPA1A
P0DMV8
7157
TP53
P04637
physical association
8729618
3303
HSPA1A
P0DMV8
387
RHOA
P61586
physical association
12490434
3303
HSPA1A
P0DMV8
367
AR
P10275
physical association
1540595
3303
HSPA1A
P0DMV8
596
BCL2
P10415
physical association
10354271
3316
HSPB2
Q16082
367
AR
P10275
physical association
17974989
3316
HSPB2
Q16082
1977
EIF4E
P06730
physical association
20101233
3316
HSPB2
Q16082
7329
UBE2I
P63279
physical association
19597476
3316
HSPB2
Q16082
3316
HSPB2
Q16082
direct interaction
10625651
3316
HSPB2
Q16082
3316
HSPB2
Q16082
physical association
10625651
3329
HSPD1
P10809
581
BAX
Q07812
physical association
12070120
3329
HSPD1
P10809
578
BAK1
Q16611
physical association
12070120
3329
HSPD1
P10809
836
CASP3
P42574
physical association
10205158
3339
HSPG2
P98160
2335
FN1
P02751
direct interaction
11493006
3339
HSPG2
P98160
5154
PDGFA
P04085
direct interaction
9692901
3399
ID3
Q02535
6925
TCF4
P15884
direct interaction
9242638
3399
ID3
Q02535
6925
TCF4
P15884
direct interaction
8999959
3399
ID3
Q02535
6925
TCF4
P15884
direct interaction
8999959
3486
IGFBP3
P17936
2335
FN1
P02751
physical association
11344214
3486
IGFBP3
P17936
2335
FN1
P02751
direct interaction
11344214
3486
IGFBP3
P17936
2335
FN1
P02751
direct interaction
11344214
3486
IGFBP3
P17936
2335
FN1
P02751
direct interaction
12127836
3486
IGFBP3
P17936
7018
TF
P02787
direct interaction
11297622
3486
IGFBP3
P17936
7018
TF
P02787
physical association
11297622
9641
IKBKE
Q14164
7128
TNFAIP3
P21580
physical association
21885437
9641
IKBKE
Q14164
7128
TNFAIP3
P21580
physical association
15661910
9641
IKBKE
Q14164
7187
TRAF3
Q13114
physical association
22079989
9641
IKBKE
Q14164
3615
IMPDH2
P12268
physical association
17353931
3615
IMPDH2
P12268
207
AKT1
P31749
direct interaction
10930578
3667
IRS1
P35568
57521
RPTOR
Q8N122
direct interaction
19561084
3667
IRS1
P35568
5295
PIK3R1
P27986
physical association
19561084
3667
IRS1
P35568
57521
RPTOR
Q8N122
physical association
19561084
3667
IRS1
P35568
3716
JAK1
P23458
physical association
7499365
3667
IRS1
P35568
207
AKT1
P31749
physical association
10497255
3667
IRS1
P35568
5295
PIK3R1
P27986
physical association
12173038
3667
IRS1
P35568
5295
PIK3R1
P27986
direct interaction
12107746
3667
IRS1
P35568
5295
PIK3R1
P27986
physical association
16354680
3667
IRS1
P35568
2099
ESR1
P03372
physical association
12821935
3667
IRS1
P35568
5290
PIK3CA
P42336
physical association
14511371
3667
IRS1
P35568
5295
PIK3R1
P27986
physical association
14511371
3667
IRS1
P35568
596
BCL2
P10415
physical association
10679027
3667
IRS1
P35568
598
BCL2L1
Q07817
physical association
10679027
3667
IRS1
P35568
2475
MTOR
P42345
physical association
11287630
3667
IRS1
P35568
5290
PIK3CA
P42336
physical association
16354680
3667
IRS1
P35568
5295
PIK3R1
P27986
physical association
12730242
3667
IRS1
P35568
5290
PIK3CA
P42336
physical association
12933652
3667
IRS1
P35568
7531
YWHAE
P62258
direct interaction
9111084
3667
IRS1
P35568
5295
PIK3R1
P27986
physical association
15514089
3667
IRS1
P35568
9021
SOCS3
O14543
physical association
15514089
83737
ITCH
Q96J02
9516
LITAF
Q99732
direct interaction
21326863
83737
ITCH
Q96J02
9516
LITAF
Q99732
physical association
21326863
83737
ITCH
Q96J02
83737
ITCH
Q96J02
direct interaction
17592138
83737
ITCH
Q96J02
10254
STAM2
O75886
direct interaction
22275353
83737
ITCH
Q96J02
857
CAV1
Q03135
physical association
22275353
83737
ITCH
Q96J02
4851
NOTCH1
P46531
physical association
10940313
83737
ITCH
Q96J02
83737
ITCH
Q96J02
physical association
18718449
83737
ITCH
Q96J02
83737
ITCH
Q96J02
direct interaction
18718449
83737
ITCH
Q96J02
83737
ITCH
Q96J02
direct interaction
22496338
83737
ITCH
Q96J02
6416
MAP2K4
P45985
direct interaction
19737936
83737
ITCH
Q96J02
6416
MAP2K4
P45985
direct interaction
19737936
83737
ITCH
Q96J02
8289
ARID1A
O14497
physical association
16055720
83737
ITCH
Q96J02
83737
ITCH
Q96J02
physical association
16055720
83737
ITCH
Q96J02
7157
TP53
P04637
physical association
21474069
83737
ITCH
Q96J02
5094
PCBP2
Q15366
physical association
19881509
83737
ITCH
Q96J02
2066
ERBB4
Q15303
physical association
18334649
83737
ITCH
Q96J02
2066
ERBB4
Q15303
direct interaction
18334649
83737
ITCH
Q96J02
4088
SMAD3
P84022
direct interaction
15051726
83737
ITCH
Q96J02
83737
ITCH
Q96J02
direct interaction
17038327
83737
ITCH
Q96J02
83737
ITCH
Q96J02
direct interaction
16446428
83737
ITCH
Q96J02
637
BID
P55957
physical association
20392206
83737
ITCH
Q96J02
3725
JUN
P05412
direct interaction
16901904
83737
ITCH
Q96J02
4193
MDM2
Q00987
physical association
21093410
83737
ITCH
Q96J02
2066
ERBB4
Q15303
direct interaction
17463226
83737
ITCH
Q96J02
2066
ERBB4
Q15303
physical association
17463226
83737
ITCH
Q96J02
2066
ERBB4
Q15303
direct interaction
17463226
83737
ITCH
Q96J02
10628
TXNIP
Q9H3M7
physical association
20068034
83737
ITCH
Q96J02
10628
TXNIP
Q9H3M7
direct interaction
20068034
3678
ITGA5
P08648
2335
FN1
P02751
physical association
20643357
182
JAG1
P78504
4853
NOTCH2
Q04721
physical association
11346656
182
JAG1
P78504
4853
NOTCH2
Q04721
physical association
10551863
182
JAG1
P78504
4853
NOTCH2
Q04721
direct interaction
10551863
182
JAG1
P78504
55294
FBXW7
Q969H0
physical association
21820430
182
JAG1
P78504
4851
NOTCH1
P46531
physical association
21820430
182
JAG1
P78504
4851
NOTCH1
P46531
colocalization
20720151
3716
JAK1
P23458
3667
IRS1
P35568
direct interaction
9492017
3716
JAK1
P23458
6774
STAT3
P40763
direct interaction
11751884
3716
JAK1
P23458
6774
STAT3
P40763
physical association
11722592
3716
JAK1
P23458
10254
STAM2
O75886
direct interaction
10993906
3716
JAK1
P23458
9021
SOCS3
O14543
physical association
10707961
3716
JAK1
P23458
9021
SOCS3
O14543
direct interaction
10373548
3716
JAK1
P23458
5894
RAF1
P04049
physical association
9446616
3716
JAK1
P23458
6776
STAT5A
P42229
direct interaction
9047382
3716
JAK1
P23458
6776
STAT5A
P42229
direct interaction
9047382
3716
JAK1
P23458
6776
STAT5A
P42229
physical association
9047382
3725
JUN
P05412
2353
FOS
P01100
direct interaction
8440710
3725
JUN
P05412
3725
JUN
P05412
direct interaction
8440710
3725
JUN
P05412
2099
ESR1
P03372
direct interaction
11477071
3725
JUN
P05412
2353
FOS
P01100
association
7816143
3725
JUN
P05412
83737
ITCH
Q96J02
physical association
19806201
3725
JUN
P05412
2353
FOS
P01100
direct interaction
10488148
3725
JUN
P05412
3725
JUN
P05412
direct interaction
10488148
3725
JUN
P05412
3725
JUN
P05412
direct interaction
7848298
3725
JUN
P05412
7153
TOP2A
P11388
direct interaction
8387155
3725
JUN
P05412
5599
MAPK8
P45983
direct interaction
12052834
3725
JUN
P05412
64326
RFWD2
Q8NHY2
physical association
12615916
3725
JUN
P05412
2353
FOS
P01100
direct interaction
9160889
3725
JUN
P05412
8061
FOSL1
P15407
direct interaction
9160889
3725
JUN
P05412
5599
MAPK8
P45983
direct interaction
22327296
3725
JUN
P05412
7329
UBE2I
P63279
direct interaction
8733011
3725
JUN
P05412
2099
ESR1
P03372
physical association
17317669
3725
JUN
P05412
2353
FOS
P01100
direct interaction
20936779
3725
JUN
P05412
2033
EP300
Q09472
direct interaction
10327051
3725
JUN
P05412
2353
FOS
P01100
physical association
20410304
3725
JUN
P05412
2353
FOS
P01100
physical association
16055710
3725
JUN
P05412
367
AR
P10275
physical association
9211894
3725
JUN
P05412
4780
NFE2L2
Q16236
physical association
20232342
3725
JUN
P05412
4609
MYC
P01106
physical association
20232342
3725
JUN
P05412
2353
FOS
P01100
direct interaction
15319445
3725
JUN
P05412
4088
SMAD3
P84022
physical association
21829441
3725
JUN
P05412
2353
FOS
P01100
direct interaction
11090181
3725
JUN
P05412
5925
RB1
P06400
direct interaction
10026157
3725
JUN
P05412
5925
RB1
P06400
physical association
10026157
3725
JUN
P05412
83737
ITCH
Q96J02
physical association
19818398
3725
JUN
P05412
25
ABL1
P00519
physical association
19818398
3725
JUN
P05412
5599
MAPK8
P45983
direct interaction
8137421
3725
JUN
P05412
3725
JUN
P05412
direct interaction
21675959
3725
JUN
P05412
2353
FOS
P01100
direct interaction
21675959
3725
JUN
P05412
5599
MAPK8
P45983
direct interaction
8586671
3725
JUN
P05412
5599
MAPK8
P45983
direct interaction
14701799
3725
JUN
P05412
5599
MAPK8
P45983
direct interaction
16983342
3725
JUN
P05412
3091
HIF1A
Q16665
physical association
11739718
3725
JUN
P05412
1026
CDKN1A
P38936
physical association
20102411
3725
JUN
P05412
6774
STAT3
P40763
physical association
10490649
3725
JUN
P05412
2353
FOS
P01100
direct interaction
8380166
3725
JUN
P05412
4780
NFE2L2
Q16236
physical association
9872330
3725
JUN
P05412
4780
NFE2L2
Q16236
direct interaction
9872330
3725
JUN
P05412
3091
HIF1A
Q16665
physical association
19738058
3725
JUN
P05412
5594
MAPK1
P28482
physical association
11431474
3725
JUN
P05412
8061
FOSL1
P15407
physical association
11431474
3725
JUN
P05412
2353
FOS
P01100
physical association
11431474
7403
KDM6A
O15550
8085
KMT2D
O14686
physical association
17761849
3791
KDR
P35968
6464
SHC1
P29353
physical association
10319320
3791
KDR
P35968
5921
RASA1
P20936
physical association
10319320
3815
KIT
P10721
5295
PIK3R1
P27986
direct interaction
9233773
3815
KIT
P10721
5295
PIK3R1
P27986
direct interaction
11071635
3815
KIT
P10721
5295
PIK3R1
P27986
direct interaction
10022833
3815
KIT
P10721
5295
PIK3R1
P27986
physical association
7509796
3815
KIT
P10721
5295
PIK3R1
P27986
physical association
17452978
688
KLF5
Q13887
2099
ESR1
P03372
direct interaction
19569049
688
KLF5
Q13887
2099
ESR1
P03372
physical association
19569049
688
KLF5
Q13887
2932
GSK3B
P49841
physical association
20388706
688
KLF5
Q13887
55294
FBXW7
Q969H0
physical association
20388706
688
KLF5
Q13887
55294
FBXW7
Q969H0
physical association
20484041
688
KLF5
Q13887
10413
YAP1
P46937
physical association
22632819
688
KLF5
Q13887
25937
WWTR1
Q9GZV5
physical association
22045023
688
KLF5
Q13887
2033
EP300
Q09472
direct interaction
15668237
688
KLF5
Q13887
2033
EP300
Q09472
physical association
14612398
688
KLF5
Q13887
2100
ESR2
Q92731
physical association
21487105
8085
KMT2D
O14686
2099
ESR1
P03372
physical association
21502505
3838
KPNA2
P52292
6446
SGK1
O00141
direct interaction
12631736
3845
KRAS
P01116
5894
RAF1
P04049
direct interaction
10783161
3845
KRAS
P01116
5290
PIK3CA
P42336
direct interaction
10783161
3853
KRT6A
P02538
3872
KRT17
Q04695
direct interaction
16189514
3927
LASP1
Q14847
9319
TRIP13
Q15645
direct interaction
16189514
3932
LCK
P06239
2185
PTK2B
Q14289
physical association
9091579
3932
LCK
P06239
3932
LCK
P06239
direct interaction
20372794
3932
LCK
P06239
1500
CTNND1
O60716
direct interaction
12835311
3932
LCK
P06239
355
FAS
P25445
direct interaction
8864141
3932
LCK
P06239
5290
PIK3CA
P42336
direct interaction
8246987
3932
LCK
P06239
5175
PECAM1
P16284
direct interaction
9624175
3932
LCK
P06239
5295
PIK3R1
P27986
direct interaction
8294442
3932
LCK
P06239
5290
PIK3CA
P42336
physical association
14583609
3932
LCK
P06239
4851
NOTCH1
P46531
physical association
14583609
3932
LCK
P06239
5921
RASA1
P20936
direct interaction
11389730
3932
LCK
P06239
6850
SYK
P43405
physical association
7539035
3932
LCK
P06239
6850
SYK
P43405
direct interaction
7539035
3932
LCK
P06239
3815
KIT
P10721
physical association
9788619
3932
LCK
P06239
9021
SOCS3
O14543
physical association
21234523
3945
LDHB
P07195
3945
LDHB
P07195
association
11276087
5604
MAP2K1
Q02750
5594
MAPK1
P28482
direct interaction
12697810
5604
MAP2K1
Q02750
5595
MAPK3
P27361
direct interaction
8626767
5604
MAP2K1
Q02750
5894
RAF1
P04049
direct interaction
10757792
5604
MAP2K1
Q02750
5594
MAPK1
P28482
direct interaction
10757792
5604
MAP2K1
Q02750
5594
MAPK1
P28482
direct interaction
11279118
5604
MAP2K1
Q02750
5594
MAPK1
P28482
direct interaction
11823456
5604
MAP2K1
Q02750
673
BRAF
P15056
physical association
16888650
5604
MAP2K1
Q02750
5595
MAPK3
P27361
direct interaction
9006895
5604
MAP2K1
Q02750
5594
MAPK1
P28482
direct interaction
11352917
5604
MAP2K1
Q02750
5594
MAPK1
P28482
physical association
11352917
5604
MAP2K1
Q02750
5595
MAPK3
P27361
direct interaction
8226933
5604
MAP2K1
Q02750
5595
MAPK3
P27361
direct interaction
8226933
5604
MAP2K1
Q02750
5604
MAP2K1
Q02750
direct interaction
8226933
5604
MAP2K1
Q02750
5894
RAF1
P04049
direct interaction
15485920
5604
MAP2K1
Q02750
5894
RAF1
P04049
physical association
15485920
6416
MAP2K4
P45985
207
AKT1
P31749
physical association
15998799
6416
MAP2K4
P45985
5599
MAPK8
P45983
physical association
15998799
6416
MAP2K4
P45985
6416
MAP2K4
P45985
direct interaction
9162092
6416
MAP2K4
P45985
1432
MAPK14
Q16539
direct interaction
9162092
6416
MAP2K4
P45985
5599
MAPK8
P45983
direct interaction
9162092
6416
MAP2K4
P45985
207
AKT1
P31749
physical association
11707464
6416
MAP2K4
P45985
5599
MAPK8
P45983
direct interaction
11707464
6416
MAP2K4
P45985
5599
MAPK8
P45983
direct interaction
11279118
6416
MAP2K4
P45985
83737
ITCH
Q96J02
physical association
19737936
6416
MAP2K4
P45985
5601
MAPK9
P45984
direct interaction
21900206
6416
MAP2K4
P45985
5599
MAPK8
P45983
direct interaction
12391307
6416
MAP2K4
P45985
5599
MAPK8
P45983
physical association
10713157
6416
MAP2K4
P45985
1432
MAPK14
Q16539
direct interaction
9808624
6416
MAP2K4
P45985
1432
MAPK14
Q16539
physical association
9808624
6416
MAP2K4
P45985
5599
MAPK8
P45983
physical association
9808624
6416
MAP2K4
P45985
5599
MAPK8
P45983
direct interaction
9808624
9448
MAP4K4
O95819
5921
RASA1
P20936
physical association
10669731
5594
MAPK1
P28482
5604
MAP2K1
Q02750
physical association
12697810
5594
MAPK1
P28482
5241
PGR
P06401
physical association
17081988
5594
MAPK1
P28482
4609
MYC
P01106
direct interaction
9207092
5594
MAPK1
P28482
5604
MAP2K1
Q02750
physical association
21336309
5594
MAPK1
P28482
2033
EP300
Q09472
direct interaction
17623675
5594
MAPK1
P28482
3725
JUN
P05412
direct interaction
10419510
5594
MAPK1
P28482
3725
JUN
P05412
direct interaction
10419510
5594
MAPK1
P28482
1843
DUSP1
P28562
direct interaction
10617468
5594
MAPK1
P28482
7157
TP53
P04637
physical association
10958792
5594
MAPK1
P28482
6667
SP1
P08047
direct interaction
17889508
5594
MAPK1
P28482
1978
EIF4EBP1
Q13541
direct interaction
12665511
5594
MAPK1
P28482
5604
MAP2K1
Q02750
direct interaction
10757792
5594
MAPK1
P28482
6256
RXRA
P19793
direct interaction
20371703
5594
MAPK1
P28482
4904
YBX1
P67809
direct interaction
16198352
5594
MAPK1
P28482
8682
PEA15
Q15121
physical association
17255949
5594
MAPK1
P28482
7249
TSC2
P49815
physical association
15851026
5594
MAPK1
P28482
7249
TSC2
P49815
direct interaction
15851026
5594
MAPK1
P28482
5894
RAF1
P04049
physical association
11409918
5594
MAPK1
P28482
6195
RPS6KA1
Q15418
direct interaction
12594221
5594
MAPK1
P28482
6667
SP1
P08047
direct interaction
11904305
5594
MAPK1
P28482
4088
SMAD3
P84022
direct interaction
19914168
5594
MAPK1
P28482
4086
SMAD1
Q15797
direct interaction
19914168
5594
MAPK1
P28482
367
AR
P10275
direct interaction
10318905
5594
MAPK1
P28482
2309
FOXO3
O43524
physical association
18204439
5594
MAPK1
P28482
2309
FOXO3
O43524
direct interaction
18204439
5594
MAPK1
P28482
5594
MAPK1
P28482
direct interaction
21110948
5594
MAPK1
P28482
595
CCND1
P24385
physical association
17205132
5594
MAPK1
P28482
5604
MAP2K1
Q02750
direct interaction
21675959
5594
MAPK1
P28482
2597
GAPDH
P04406
direct interaction
18624398
5594
MAPK1
P28482
57521
RPTOR
Q8N122
direct interaction
21071439
5594
MAPK1
P28482
57521
RPTOR
Q8N122
direct interaction
21071439
5594
MAPK1
P28482
9846
GAB2
Q9UQC2
direct interaction
14530346
5594
MAPK1
P28482
9759
HDAC4
P56524
direct interaction
11114188
5594
MAPK1
P28482
6464
SHC1
P29353
physical association
10996427
5594
MAPK1
P28482
6776
STAT5A
P42229
physical association
10996427
5594
MAPK1
P28482
708
C1QBP
Q07021
direct interaction
11866440
5594
MAPK1
P28482
1843
DUSP1
P28562
physical association
11278799
5594
MAPK1
P28482
2099
ESR1
P03372
direct interaction
11358671
5594
MAPK1
P28482
2100
ESR2
Q92731
direct interaction
11358671
5594
MAPK1
P28482
57521
RPTOR
Q8N122
direct interaction
21325048
5594
MAPK1
P28482
2932
GSK3B
P49841
direct interaction
16039586
5594
MAPK1
P28482
6195
RPS6KA1
Q15418
physical association
16039586
5594
MAPK1
P28482
2932
GSK3B
P49841
physical association
16039586
5594
MAPK1
P28482
7153
TOP2A
P11388
direct interaction
10207078
5594
MAPK1
P28482
7153
TOP2A
P11388
direct interaction
10207078
5594
MAPK1
P28482
5604
MAP2K1
Q02750
direct interaction
11266467
5594
MAPK1
P28482
1051
CEBPB
P17676
direct interaction
11500490
5594
MAPK1
P28482
4086
SMAD1
Q15797
direct interaction
17289590
1432
MAPK14
Q16539
5594
MAPK1
P28482
physical association
12697810
1432
MAPK14
Q16539
5595
MAPK3
P27361
physical association
12697810
1432
MAPK14
Q16539
1843
DUSP1
P28562
physical association
11359773
1432
MAPK14
Q16539
207
AKT1
P31749
direct interaction
11042204
1432
MAPK14
Q16539
2033
EP300
Q09472
direct interaction
21444723
1432
MAPK14
Q16539
1432
MAPK14
Q16539
direct interaction
12819782
1432
MAPK14
Q16539
1843
DUSP1
P28562
direct interaction
20936779
1432
MAPK14
Q16539
5925
RB1
P06400
direct interaction
20871633
1432
MAPK14
Q16539
1978
EIF4EBP1
Q13541
direct interaction
20090955
1432
MAPK14
Q16539
207
AKT1
P31749
direct interaction
16982329
1432
MAPK14
Q16539
5594
MAPK1
P28482
physical association
11157753
1432
MAPK14
Q16539
1432
MAPK14
Q16539
direct interaction
11847341
1432
MAPK14
Q16539
5595
MAPK3
P27361
direct interaction
21675959
1432
MAPK14
Q16539
5594
MAPK1
P28482
direct interaction
21675959
1432
MAPK14
Q16539
1956
EGFR
P00533
direct interaction
7535770
1432
MAPK14
Q16539
7157
TP53
P04637
physical association
17172861
1432
MAPK14
Q16539
1843
DUSP1
P28562
physical association
11278799
1432
MAPK14
Q16539
6667
SP1
P08047
physical association
18419748
5595
MAPK3
P27361
5595
MAPK3
P27361
direct interaction
19847302
5595
MAPK3
P27361
2194
FASN
P49327
physical association
19847302
5595
MAPK3
P27361
506
ATP5B
P06576
physical association
19847302
5595
MAPK3
P27361
3033
HADH
Q16836
physical association
19847302
5595
MAPK3
P27361
3725
JUN
P05412
direct interaction
1922387
5595
MAPK3
P27361
673
BRAF
P15056
additive genetic interaction defined by inequality
10869359
5595
MAPK3
P27361
5604
MAP2K1
Q02750
physical association
9733512
5595
MAPK3
P27361
1843
DUSP1
P28562
direct interaction
10617468
5595
MAPK3
P27361
7157
TP53
P04637
physical association
10958792
5595
MAPK3
P27361
6667
SP1
P08047
direct interaction
17889508
5595
MAPK3
P27361
6256
RXRA
P19793
direct interaction
20371703
5595
MAPK3
P27361
5894
RAF1
P04049
physical association
11409918
5595
MAPK3
P27361
6667
SP1
P08047
direct interaction
11904305
5595
MAPK3
P27361
9846
GAB2
Q9UQC2
direct interaction
14530346
5595
MAPK3
P27361
5604
MAP2K1
Q02750
direct interaction
8226933
5595
MAPK3
P27361
5604
MAP2K1
Q02750
colocalization
10748187
5595
MAPK3
P27361
5604
MAP2K1
Q02750
physical association
10748187
5595
MAPK3
P27361
1401
CRP
P02741
direct interaction
18624398
5595
MAPK3
P27361
57521
RPTOR
Q8N122
direct interaction
21071439
5595
MAPK3
P27361
57521
RPTOR
Q8N122
direct interaction
21071439
5595
MAPK3
P27361
9759
HDAC4
P56524
direct interaction
11114188
5595
MAPK3
P27361
708
C1QBP
Q07021
direct interaction
11866440
5595
MAPK3
P27361
8682
PEA15
Q15121
direct interaction
21900206
5599
MAPK8
P45983
3667
IRS1
P35568
direct interaction
11606564
5599
MAPK8
P45983
7157
TP53
P04637
physical association
11108663
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
11108663
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
12228228
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
20133937
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
9207092
5599
MAPK8
P45983
6416
MAP2K4
P45985
additive genetic interaction defined by inequality
9207092
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
22327296
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
11479302
5599
MAPK8
P45983
6416
MAP2K4
P45985
direct interaction
16533805
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
16533805
5599
MAPK8
P45983
5604
MAP2K1
Q02750
direct interaction
16533805
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
10419510
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
10419510
5599
MAPK8
P45983
6774
STAT3
P40763
direct interaction
10521505
5599
MAPK8
P45983
7157
TP53
P04637
physical association
18813780
5599
MAPK8
P45983
4609
MYC
P01106
physical association
10551811
5599
MAPK8
P45983
4609
MYC
P01106
direct interaction
10551811
5599
MAPK8
P45983
7157
TP53
P04637
physical association
9732264
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
18922473
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
18957422
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
20732415
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
15590691
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
10962563
5599
MAPK8
P45983
7157
TP53
P04637
direct interaction
9724739
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
9774977
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
15299005
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
19270716
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
16157600
5599
MAPK8
P45983
57521
RPTOR
Q8N122
physical association
22493283
5599
MAPK8
P45983
2475
MTOR
P42345
physical association
22493283
5599
MAPK8
P45983
3667
IRS1
P35568
physical association
10722755
5599
MAPK8
P45983
3667
IRS1
P35568
direct interaction
10722755
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
8621542
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
9692890
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
12185592
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
9575168
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
14572659
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
8137421
5599
MAPK8
P45983
7157
TP53
P04637
direct interaction
19651615
5599
MAPK8
P45983
23411
SIRT1
Q96EB6
direct interaction
20027304
5599
MAPK8
P45983
23411
SIRT1
Q96EB6
physical association
20027304
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
16740711
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
16434970
5599
MAPK8
P45983
596
BCL2
P10415
direct interaction
15733859
5599
MAPK8
P45983
5599
MAPK8
P45983
direct interaction
20194509
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
8586671
5599
MAPK8
P45983
1843
DUSP1
P28562
physical association
11278799
5599
MAPK8
P45983
3164
NR4A1
P22736
direct interaction
17023523
5599
MAPK8
P45983
83737
ITCH
Q96J02
physical association
16446428
5599
MAPK8
P45983
83737
ITCH
Q96J02
direct interaction
16446428
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
14633987
5599
MAPK8
P45983
7157
TP53
P04637
direct interaction
15538975
5599
MAPK8
P45983
1026
CDKN1A
P38936
physical association
20102411
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
15749833
5599
MAPK8
P45983
7157
TP53
P04637
physical association
9393873
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
9808624
5599
MAPK8
P45983
1499
CTNNB1
P35222
physical association
19667122
5599
MAPK8
P45983
1499
CTNNB1
P35222
direct interaction
19667122
5599
MAPK8
P45983
64783
RBM15
Q96T37
direct interaction
21900206
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
15958389
5599
MAPK8
P45983
3164
NR4A1
P22736
direct interaction
14612408
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
14612408
5599
MAPK8
P45983
3725
JUN
P05412
direct interaction
14517282
5601
MAPK9
P45984
6416
MAP2K4
P45985
physical association
22366412
5601
MAPK9
P45984
3725
JUN
P05412
direct interaction
16533805
5601
MAPK9
P45984
7157
TP53
P04637
direct interaction
12384512
5601
MAPK9
P45984
3725
JUN
P05412
direct interaction
10490605
5601
MAPK9
P45984
3725
JUN
P05412
direct interaction
8985011
5601
MAPK9
P45984
3725
JUN
P05412
direct interaction
8945519
5601
MAPK9
P45984
284403
WDR62
O43379
direct interaction
16189514
5601
MAPK9
P45984
1499
CTNNB1
P35222
physical association
19667122
5601
MAPK9
P45984
1499
CTNNB1
P35222
direct interaction
19667122
4137
MAPT
P10636
2932
GSK3B
P49841
physical association
22965877
4137
MAPT
P10636
2932
GSK3B
P49841
direct interaction
21985244
4137
MAPT
P10636
6850
SYK
P43405
physical association
18070606
4137
MAPT
P10636
23411
SIRT1
Q96EB6
direct interaction
20869593
4137
MAPT
P10636
23411
SIRT1
Q96EB6
physical association
20869593
4137
MAPT
P10636
7529
YWHAB
P31946
physical association
10840038
4137
MAPT
P10636
7534
YWHAZ
P63104
physical association
10840038
4170
MCL1
Q07820
10018
BCL2L11
O43521
physical association
19148187
4170
MCL1
Q07820
581
BAX
Q07812
physical association
19148187
4170
MCL1
Q07820
578
BAK1
Q16611
physical association
19148187
4170
MCL1
Q07820
572
BAD
Q92934
direct interaction
11483855
4170
MCL1
Q07820
578
BAK1
Q16611
physical association
15901672
4170
MCL1
Q07820
578
BAK1
Q16611
direct interaction
15901672
4170
MCL1
Q07820
10018
BCL2L11
O43521
physical association
19622586
4170
MCL1
Q07820
637
BID
P55957
direct interaction
15637055
4170
MCL1
Q07820
637
BID
P55957
physical association
15637055
4170
MCL1
Q07820
578
BAK1
Q16611
direct interaction
15637055
4170
MCL1
Q07820
578
BAK1
Q16611
direct interaction
15077116
4170
MCL1
Q07820
578
BAK1
Q16611
physical association
15077116
4170
MCL1
Q07820
10018
BCL2L11
O43521
physical association
20074640
4170
MCL1
Q07820
578
BAK1
Q16611
direct interaction
21613222
4170
MCL1
Q07820
10018
BCL2L11
O43521
direct interaction
21613222
4170
MCL1
Q07820
637
BID
P55957
direct interaction
21613222
4170
MCL1
Q07820
4170
MCL1
Q07820
direct interaction
10837489
4170
MCL1
Q07820
4170
MCL1
Q07820
physical association
10837489
4170
MCL1
Q07820
598
BCL2L1
Q07817
physical association
10837489
4170
MCL1
Q07820
10018
BCL2L11
O43521
physical association
15989957
4170
MCL1
Q07820
637
BID
P55957
direct interaction
15694340
4170
MCL1
Q07820
572
BAD
Q92934
direct interaction
15694340
4191
MDH2
P40926
4191
MDH2
P40926
direct interaction
9792106
4193
MDM2
Q00987
7015
TERT
O14746
direct interaction
20453884
4193
MDM2
Q00987
7015
TERT
O14746
direct interaction
20453884
4193
MDM2
Q00987
7015
TERT
O14746
physical association
20453884
4193
MDM2
Q00987
1869
E2F1
Q01094
direct interaction
18754770
4193
MDM2
Q00987
1869
E2F1
Q01094
physical association
18754770
4193
MDM2
Q00987
7157
TP53
P04637
physical association
15094782
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
20639885
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
20639885
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
21965653
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
19160491
4193
MDM2
Q00987
7157
TP53
P04637
physical association
11713288
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
16678796
4193
MDM2
Q00987
5925
RB1
P06400
physical association
15485814
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
16173922
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
physical association
16173922
4193
MDM2
Q00987
7157
TP53
P04637
physical association
15144954
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
11925449
4193
MDM2
Q00987
7157
TP53
P04637
physical association
11925449
4193
MDM2
Q00987
7157
TP53
P04637
physical association
20234175
4193
MDM2
Q00987
7157
TP53
P04637
physical association
11697899
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
15001357
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
15933712
4193
MDM2
Q00987
7157
TP53
P04637
physical association
22948151
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
physical association
11223036
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
22331460
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
11046142
4193
MDM2
Q00987
7157
TP53
P04637
physical association
22819825
4193
MDM2
Q00987
7157
TP53
P04637
physical association
16023600
4193
MDM2
Q00987
7157
TP53
P04637
physical association
21925390
4193
MDM2
Q00987
7329
UBE2I
P63279
physical association
11384992
4193
MDM2
Q00987
5925
RB1
P06400
physical association
7791904
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
22916255
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
11285227
4193
MDM2
Q00987
7157
TP53
P04637
physical association
22266868
4193
MDM2
Q00987
7157
TP53
P04637
physical association
22920093
4193
MDM2
Q00987
6659
SOX4
Q06945
physical association
19234109
4193
MDM2
Q00987
7157
TP53
P04637
physical association
21454483
4193
MDM2
Q00987
7157
TP53
P04637
physical association
10435614
4193
MDM2
Q00987
7157
TP53
P04637
physical association
11431470
4193
MDM2
Q00987
7157
TP53
P04637
physical association
22912717
4193
MDM2
Q00987
7157
TP53
P04637
physical association
12208736
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
15950904
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
15950904
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
18981217
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
physical association
18813780
4193
MDM2
Q00987
7157
TP53
P04637
physical association
18813780
4193
MDM2
Q00987
7157
TP53
P04637
colocalization
11112690
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
22301280
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
physical association
17116689
4193
MDM2
Q00987
5925
RB1
P06400
physical association
20871633
4193
MDM2
Q00987
7157
TP53
P04637
physical association
17116689
4193
MDM2
Q00987
387
RHOA
P61586
physical association
22907703
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
22103682
4193
MDM2
Q00987
4851
NOTCH1
P46531
physical association
22128911
4193
MDM2
Q00987
7157
TP53
P04637
physical association
22157679
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
22157679
4193
MDM2
Q00987
11200
CHEK2
O96017
physical association
19176998
4193
MDM2
Q00987
7157
TP53
P04637
physical association
22474335
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
22474335
4193
MDM2
Q00987
7157
TP53
P04637
physical association
19085961
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
20588255
4193
MDM2
Q00987
7157
TP53
P04637
physical association
20588255
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
physical association
16107876
4193
MDM2
Q00987
7157
TP53
P04637
physical association
16107876
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
19568783
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
15242646
4193
MDM2
Q00987
1869
E2F1
Q01094
physical association
16170383
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
21084564
4193
MDM2
Q00987
7157
TP53
P04637
physical association
18566590
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
18264029
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
18264029
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
10722742
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
10722742
4193
MDM2
Q00987
7157
TP53
P04637
physical association
10488081
4193
MDM2
Q00987
7157
TP53
P04637
physical association
14559824
4193
MDM2
Q00987
7157
TP53
P04637
physical association
18815136
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
17525743
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
21887275
4193
MDM2
Q00987
7157
TP53
P04637
physical association
21887275
4193
MDM2
Q00987
7157
TP53
P04637
physical association
22374672
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
direct interaction
10822382
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
physical association
22120712
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
20173098
4193
MDM2
Q00987
3091
HIF1A
Q16665
direct interaction
12606552
4193
MDM2
Q00987
7157
TP53
P04637
physical association
11709713
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
16845383
4193
MDM2
Q00987
7157
TP53
P04637
physical association
17908790
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
16845383
4193
MDM2
Q00987
7157
TP53
P04637
physical association
16845383
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
20484049
4193
MDM2
Q00987
4193
MDM2
Q00987
physical association
20484049
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
20484049
4193
MDM2
Q00987
7157
TP53
P04637
physical association
21478269
4193
MDM2
Q00987
7157
TP53
P04637
physical association
15824742
4193
MDM2
Q00987
4193
MDM2
Q00987
physical association
17936559
4193
MDM2
Q00987
7157
TP53
P04637
physical association
17666403
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
18172499
4193
MDM2
Q00987
7157
TP53
P04637
physical association
18172499
4193
MDM2
Q00987
7157
TP53
P04637
physical association
22575647
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
18485870
4193
MDM2
Q00987
64326
RFWD2
Q8NHY2
physical association
20333547
4193
MDM2
Q00987
4193
MDM2
Q00987
physical association
17426254
4193
MDM2
Q00987
7157
TP53
P04637
physical association
17426254
4193
MDM2
Q00987
7157
TP53
P04637
physical association
21986495
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
14671306
4193
MDM2
Q00987
7157
TP53
P04637
physical association
20542919
4193
MDM2
Q00987
7157
TP53
P04637
physical association
11714701
4193
MDM2
Q00987
2309
FOXO3
O43524
physical association
18204439
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
19683495
4193
MDM2
Q00987
7157
TP53
P04637
physical association
19081178
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
physical association
20395212
4193
MDM2
Q00987
7157
TP53
P04637
physical association
20395212
4193
MDM2
Q00987
2309
FOXO3
O43524
physical association
19321440
4193
MDM2
Q00987
6275
S100A4
P26447
direct interaction
20591429
4193
MDM2
Q00987
6273
S100A2
P29034
direct interaction
20591429
4193
MDM2
Q00987
7157
TP53
P04637
physical association
11597128
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
20479273
4193
MDM2
Q00987
7157
TP53
P04637
physical association
20479273
4193
MDM2
Q00987
7157
TP53
P04637
association
8875929
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
19816404
4193
MDM2
Q00987
3091
HIF1A
Q16665
direct interaction
10640274
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
19619542
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
physical association
9529248
4193
MDM2
Q00987
10111
RAD50
Q92878
physical association
15734743
4193
MDM2
Q00987
4361
MRE11A
P49959
physical association
15734743
4193
MDM2
Q00987
4683
NBN
O60934
physical association
15734743
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
physical association
12085228
4193
MDM2
Q00987
4683
NBN
O60934
physical association
15734743
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
19857530
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
direct interaction
12085228
4193
MDM2
Q00987
10111
RAD50
Q92878
physical association
15734743
4193
MDM2
Q00987
4361
MRE11A
P49959
physical association
15734743
4193
MDM2
Q00987
7157
TP53
P04637
physical association
19098711
4193
MDM2
Q00987
7157
TP53
P04637
physical association
22032989
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
14596917
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
14596917
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
22032989
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
18665269
4193
MDM2
Q00987
5292
PIM1
P11309
direct interaction
18467333
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
18467333
4193
MDM2
Q00987
5292
PIM1
P11309
physical association
18467333
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
physical association
18467333
4193
MDM2
Q00987
1026
CDKN1A
P38936
physical association
14761977
4193
MDM2
Q00987
1026
CDKN1A
P38936
direct interaction
14761977
4193
MDM2
Q00987
7157
TP53
P04637
physical association
22227409
4193
MDM2
Q00987
5469
MED1
Q15648
physical association
15848166
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
22493164
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
17290220
4193
MDM2
Q00987
7157
TP53
P04637
physical association
20659896
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
19656744
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
20694676
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
12381304
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
19166840
4193
MDM2
Q00987
7157
TP53
P04637
physical association
19106616
4193
MDM2
Q00987
7157
TP53
P04637
physical association
19106616
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
21572037
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
16579792
4193
MDM2
Q00987
7157
TP53
P04637
physical association
10561590
4193
MDM2
Q00987
7157
TP53
P04637
physical association
19837670
4193
MDM2
Q00987
7157
TP53
P04637
physical association
16547496
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
20962272
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
16714300
4193
MDM2
Q00987
4683
NBN
O60934
physical association
18541670
4193
MDM2
Q00987
7157
TP53
P04637
physical association
18541670
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
19303885
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
physical association
18541670
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
18309296
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
21060154
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
21060154
4193
MDM2
Q00987
7157
TP53
P04637
physical association
21060154
4193
MDM2
Q00987
9260
PDLIM7
Q9NR12
direct interaction
21060154
4193
MDM2
Q00987
9260
PDLIM7
Q9NR12
physical association
21060154
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
22124327
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
16866370
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
20124408
4193
MDM2
Q00987
4193
MDM2
Q00987
physical association
16905769
4193
MDM2
Q00987
7157
TP53
P04637
physical association
16905769
4193
MDM2
Q00987
7157
TP53
P04637
physical association
18332869
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
16857591
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
21084285
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
21084285
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
17301054
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
17301054
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
16803902
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
physical association
18583933
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
9450543
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
22444248
4193
MDM2
Q00987
207
AKT1
P31749
physical association
12145204
4193
MDM2
Q00987
4193
MDM2
Q00987
colocalization
17170710
4193
MDM2
Q00987
4193
MDM2
Q00987
association
17170710
4193
MDM2
Q00987
7157
TP53
P04637
physical association
21316347
4193
MDM2
Q00987
2033
EP300
Q09472
direct interaction
9809062
4193
MDM2
Q00987
7157
TP53
P04637
colocalization
9809062
4193
MDM2
Q00987
2033
EP300
Q09472
physical association
9809062
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
19305137
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
16870621
4193
MDM2
Q00987
7157
TP53
P04637
physical association
16870621
4193
MDM2
Q00987
7157
TP53
P04637
physical association
12944468
4193
MDM2
Q00987
7157
TP53
P04637
physical association
11839577
4193
MDM2
Q00987
7157
TP53
P04637
physical association
15064742
4193
MDM2
Q00987
2065
ERBB3
P21860
physical association
21930127
4193
MDM2
Q00987
207
AKT1
P31749
physical association
21930127
4193
MDM2
Q00987
2099
ESR1
P03372
direct interaction
17545634
4193
MDM2
Q00987
7157
TP53
P04637
physical association
15308643
4193
MDM2
Q00987
2099
ESR1
P03372
physical association
17545634
4193
MDM2
Q00987
4193
MDM2
Q00987
physical association
22333590
4193
MDM2
Q00987
7157
TP53
P04637
physical association
22389628
4193
MDM2
Q00987
7157
TP53
P04637
physical association
9582019
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
15001357
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
15001357
4193
MDM2
Q00987
4193
MDM2
Q00987
direct interaction
15001357
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
20705607
4193
MDM2
Q00987
7157
TP53
P04637
physical association
17139261
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
17139261
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
17875722
4193
MDM2
Q00987
7157
TP53
P04637
physical association
20235143
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
16159876
4193
MDM2
Q00987
7157
TP53
P04637
suppressive genetic interaction defined by inequality
16201274
4193
MDM2
Q00987
11200
CHEK2
O96017
physical association
15862297
4193
MDM2
Q00987
11200
CHEK2
O96017
direct interaction
15862297
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
physical association
14612427
4193
MDM2
Q00987
7157
TP53
P04637
physical association
14612427
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
physical association
14612427
4193
MDM2
Q00987
4193
MDM2
Q00987
association
16965791
4193
MDM2
Q00987
7157
TP53
P04637
physical association
16624812
4193
MDM2
Q00987
999
CDH1
P12830
physical association
16980628
4193
MDM2
Q00987
7157
TP53
P04637
physical association
20657550
4193
MDM2
Q00987
6198
RPS6KB1
P23443
physical association
20657550
4193
MDM2
Q00987
2099
ESR1
P03372
direct interaction
11178989
4193
MDM2
Q00987
7157
TP53
P04637
physical association
19411846
4193
MDM2
Q00987
7157
TP53
P04637
physical association
21261729
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
21088494
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
21471462
4193
MDM2
Q00987
7157
TP53
P04637
physical association
21471462
4193
MDM2
Q00987
1026
CDKN1A
P38936
direct interaction
20308078
4193
MDM2
Q00987
7157
TP53
P04637
physical association
18604177
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
physical association
10801444
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
16338390
4193
MDM2
Q00987
7157
TP53
P04637
physical association
17318220
4193
MDM2
Q00987
367
AR
P10275
colocalization
15640443
4193
MDM2
Q00987
7157
TP53
P04637
physical association
16414131
4193
MDM2
Q00987
7157
TP53
P04637
physical association
19033382
4193
MDM2
Q00987
7157
TP53
P04637
physical association
19411066
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
17848574
4193
MDM2
Q00987
7157
TP53
P04637
physical association
17848574
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
17848574
4193
MDM2
Q00987
7157
TP53
P04637
physical association
22737255
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
physical association
9529249
4193
MDM2
Q00987
7157
TP53
P04637
physical association
9529249
4193
MDM2
Q00987
1029
CDKN2A
Q8N726
direct interaction
9529249
4193
MDM2
Q00987
7157
TP53
P04637
physical association
10889512
4193
MDM2
Q00987
1026
CDKN1A
P38936
physical association
17373842
4193
MDM2
Q00987
7157
TP53
P04637
physical association
15058298
4193
MDM2
Q00987
2597
GAPDH
P04406
physical association
17373842
4193
MDM2
Q00987
4193
MDM2
Q00987
physical association
17373842
4193
MDM2
Q00987
5087
PBX1
P40424
direct interaction
23044487
4193
MDM2
Q00987
83737
ITCH
Q96J02
physical association
21093410
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
10640350
4193
MDM2
Q00987
25
ABL1
P00519
direct interaction
12110584
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
7686617
4193
MDM2
Q00987
7157
TP53
P04637
physical association
16861890
4193
MDM2
Q00987
5925
RB1
P06400
physical association
21990374
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
15013777
4193
MDM2
Q00987
7157
TP53
P04637
physical association
10827196
4193
MDM2
Q00987
7157
TP53
P04637
physical association
18234963
4193
MDM2
Q00987
7157
TP53
P04637
association
15154850
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
21584881
4193
MDM2
Q00987
7157
TP53
P04637
physical association
21098709
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
17159902
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
15908921
4193
MDM2
Q00987
367
AR
P10275
direct interaction
21157430
4193
MDM2
Q00987
7157
TP53
P04637
physical association
22487680
4193
MDM2
Q00987
7157
TP53
P04637
physical association
22525275
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
17301054
4193
MDM2
Q00987
5347
PLK1
P53350
direct interaction
19833129
4193
MDM2
Q00987
7157
TP53
P04637
physical association
17380154
4193
MDM2
Q00987
5111
PCNA
P12004
physical association
16861890
4193
MDM2
Q00987
7157
TP53
P04637
direct interaction
11486026
4204
MECP2
P51608
5468
PPARG
P37231
physical association
21151932
4204
MECP2
P51608
4904
YBX1
P67809
physical association
22615490
4204
MECP2
P51608
6667
SP1
P08047
physical association
20385708
4204
MECP2
P51608
1786
DNMT1
P26358
physical association
12473678
4204
MECP2
P51608
1786
DNMT1
P26358
direct interaction
12473678
4204
MECP2
P51608
3146
HMGB1
P09429
direct interaction
11748221
4204
MECP2
P51608
4904
YBX1
P67809
physical association
16251272
5469
MED1
Q15648
5469
MED1
Q15648
direct interaction
9444950
5469
MED1
Q15648
7157
TP53
P04637
direct interaction
9444950
5469
MED1
Q15648
2099
ESR1
P03372
physical association
12837248
5469
MED1
Q15648
5469
MED1
Q15648
physical association
20133760
5469
MED1
Q15648
5469
MED1
Q15648
physical association
15989967
5469
MED1
Q15648
4193
MDM2
Q00987
physical association
15848166
5469
MED1
Q15648
5468
PPARG
P37231
direct interaction
15604093
5469
MED1
Q15648
5468
PPARG
P37231
physical association
17468099
5469
MED1
Q15648
367
AR
P10275
physical association
12218053
5469
MED1
Q15648
2099
ESR1
P03372
direct interaction
10770935
5469
MED1
Q15648
2100
ESR2
Q92731
direct interaction
10770935
5469
MED1
Q15648
2100
ESR2
Q92731
direct interaction
10770935
5469
MED1
Q15648
2099
ESR1
P03372
direct interaction
10770935
5469
MED1
Q15648
6256
RXRA
P19793
direct interaction
10935544
5469
MED1
Q15648
5468
PPARG
P37231
direct interaction
10935544
4211
MEIS1
O00470
5087
PBX1
P40424
physical association
20237320
4211
MEIS1
O00470
5087
PBX1
P40424
direct interaction
10082572
4212
MEIS2
O14770
5087
PBX1
P40424
direct interaction
20211142
4233
MET
P08581
3082
HGF
P14210
direct interaction
8380735
4233
MET
P08581
3082
HGF
P14210
direct interaction
8380735