Examples


Enzyme Targets for Metabolites

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Enzymes significant for muscle invasive bladder cancer metabolites

All enzymes displayed are obtained from the Human Metabolome Database for individual metabolite

Metabolite Name
Metabolite Id
Metabolite Expression in MIBC
Related Enzyme
UniProt Id
Cytosine
HMDB00630
up
A1CF
Q9NQ94
3-Hydroxykynurenine
HMDB00732
up
AADAT
Q8N5Z0
Kynurenine
HMDB00684
up
AADAT
Q8N5Z0
Lysine
HMDB00182
up
AASS
Q9UDR5
Spermidine
HMDB01257
up
ACAA2
P42765
Spermidine
HMDB01257
up
ACAA2
P42765
Phenylalanine
HMDB00159
up
ACE2
Q9BYF1
Phytosphingosine
HMDB04610
up
ACER1
Q8TDN7
palmitic acid
HMDB00220
down
ACER1
Q8TDN7
Phytosphingosine
HMDB04610
up
ACER2
Q5QJU3
palmitic acid
HMDB00220
down
ACER2
Q5QJU3
palmitic acid
HMDB00220
down
ACOT1
Q86TX2
palmitic acid
HMDB00220
down
ACOT2
P49753
palmitic acid
HMDB00220
down
ACOT4
Q8N9L9
palmitic acid
HMDB00220
down
ACOT7
O00154
palmitic acid
HMDB00220
down
ACOT7L
Q6ZUV0
palmitic acid
HMDB00220
down
ACOT8
O14734
palmitic acid
HMDB00220
down
ACSBG1
Q96GR2
palmitic acid
HMDB00220
down
ACSBG2
Q5FVE4
palmitic acid
HMDB00220
down
ACSL1
P33121
palmitic acid
HMDB00220
down
ACSL3
O95573
palmitic acid
HMDB00220
down
ACSL4
O60488
palmitic acid
HMDB00220
down
ACSL5
Q9ULC5
palmitic acid
HMDB00220
down
ACSL6
Q9UKU0
palmitic acid
HMDB00220
down
ACY1
Q03154
palmitic acid
HMDB00220
down
ACY3
Q96HD9
palmitic acid
HMDB00220
down
ACYP1
P07311
palmitic acid
HMDB00220
down
ACYP2
P14621
Adenosine
HMDB00050
down
ADA
P00813
Adenosine
HMDB00050
down
ADK
P55263
Adenosine
HMDB00050
down
ADORA1
P30542
Adenosine
HMDB00050
down
ADORA2A
P29274
Adenosine
HMDB00050
down
ADORA2B
P29275
Phosphorylcholine
HMDB01565
down
ADPRM
Q3LIE5
Phosphorylcholine
HMDB01565
up
ADPRM
Q3LIE5
3-Hydroxykynurenine
HMDB00732
up
AFMID
Q63HM1
Kynurenine
HMDB00684
up
AFMID
Q63HM1
Spermidine
HMDB01257
up
AGMAT
Q9BSE5
Spermidine
HMDB01257
up
AGMAT
Q9BSE5
Spermine
HMDB01256
up
AGMAT
Q9BSE5
S-Adenosylmethionine
HMDB01185
up
AHCY
P23526
Adenosine
HMDB00050
down
AHCY
P23526
S-Adenosylmethionine
HMDB01185
up
AHCYL1
O43865
Adenosine
HMDB00050
down
AHCYL1
O43865
S-Adenosylmethionine
HMDB01185
up
AHCYL2
Q96HN2
Adenosine
HMDB00050
down
AHCYL2
Q96HN2
Uridine
HMDB00296
down
AID
Q546Y9
5-Hydroxyindoleacetic acid
HMDB00763
up
ALDH1A3
P47895
5-Hydroxyindoleacetic acid
HMDB00763
up
ALDH1B1
P30837
5-Hydroxyindoleacetic acid
HMDB00763
up
ALDH2
P05091
5-Hydroxyindoleacetic acid
HMDB00763
up
ALDH3A2
P51648
5-Hydroxyindoleacetic acid
HMDB00763
up
ALDH7A1
P49419
5-Hydroxyindoleacetic acid
HMDB00763
up
ALDH9A1
P49189
Spermine
HMDB01256
up
ALDH9A1
P49189
Spermidine
HMDB01257
up
ALDH9A1
P49189
Spermidine
HMDB01257
up
ALDH9A1
P49189
S-Adenosylmethionine
HMDB01185
up
ALKBH8
Q96BT7
Spermine
HMDB01256
up
AMD1
P17707
S-Adenosylmethionine
HMDB01185
up
AMD1
P17707
Spermidine
HMDB01257
up
AMD1
P17707
Spermidine
HMDB01257
up
AMD1
P17707
Pyroglutamic acid
HMDB00267
up
AMY1A
P04745
Pyroglutamic acid
HMDB00267
up
AMY2A
P04746
Pyroglutamic acid
HMDB00267
up
AMY2B
P19961
Pyroglutamic acid
HMDB00267
up
ANG
P03950
Spermine
HMDB01256
up
AOC1
P19801
histamine
HMDB00870
down
AOC1
P19801
histamine
HMDB00870
down
AOC2
O75106
5-Hydroxyindoleacetic acid
HMDB00763
up
AOX1
Q06278
Uridine
HMDB00296
down
APOBEC3A
P31941
Uridine
HMDB00296
down
APOBEC3B
Q9UH17
Uridine
HMDB00296
down
APOBEC3C
Q9NRW3
Uridine
HMDB00296
down
APOBEC3D
Q96AK3
Uridine
HMDB00296
down
APOBEC3F
Q8IUX4
Uridine
HMDB00296
down
APOBEC3H
Q6NTF7
guanine
HMDB00132
up
APRT
P07741
S-Adenosylmethionine
HMDB01185
up
AS3MT
Q9HBK9
Phytosphingosine
HMDB04610
up
ASAH1
Q13510
palmitic acid
HMDB00220
down
ASAH1
Q13510
palmitic acid
HMDB00220
down
ASAH2
Q9NR71
palmitic acid
HMDB00220
down
ASAH2C
P0C7U2
S-Adenosylmethionine
HMDB01185
up
ASH1L
Q9NR48
5-Hydroxyindoleacetic acid
HMDB00763
up
ASMT
P46597
S-Adenosylmethionine
HMDB01185
up
ASMT
P46597
S-Adenosylmethionine
HMDB01185
up
ASMTL
O95671
palmitic acid
HMDB00220
down
ASPA
P45381
palmitic acid
HMDB00220
down
ASPG
Q86U10
Phytosphingosine
HMDB04610
up
B3GALT5
Q9Y2C3
Phytosphingosine
HMDB04610
up
B3GNT5
Q9BYG0
palmitic acid
HMDB00220
down
BAAT
Q14032
Spermine
HMDB01256
up
BBOX1
O75936
L-Carnitine
HMDB00062
up
BBOX1
O75936
Spermidine
HMDB01257
up
BBOX1
O75936
Spermidine
HMDB01257
up
BBOX1
O75936
Valine
HMDB00883
up
BCAT1
P54687
Valine
HMDB00883
up
BCAT2
O15382
palmitic acid
HMDB00220
down
BCHE
P06276
Spermine
HMDB01256
up
BHMT
Q93088
Spermidine
HMDB01257
up
BHMT
Q93088
Spermidine
HMDB01257
up
BHMT
Q93088
Spermine
HMDB01256
up
BHMT2
Q9H2M3
Spermidine
HMDB01257
up
BHMT2
Q9H2M3
Spermidine
HMDB01257
up
BHMT2
Q9H2M3
Lysine
HMDB00182
up
BTD
P43251
S-Adenosylmethionine
HMDB01185
up
CAMKMT
Q7Z624
S-Adenosylmethionine
HMDB01185
up
CARM1
Q86X55
Histidine
HMDB00177
up
CARNS1
A5YM72
Lysine
HMDB00182
up
CARNS1
A5YM72
S-Adenosylmethionine
HMDB01185
up
CBS
P35520
3-Hydroxykynurenine
HMDB00732
up
CCBL1
Q16773
Kynurenine
HMDB00684
up
CCBL1
Q16773
Phenylalanine
HMDB00159
up
CCBL1
Q16773
3-Hydroxykynurenine
HMDB00732
up
CCBL2
Q6YP21
Kynurenine
HMDB00684
up
CCBL2
Q6YP21
Phytosphingosine
HMDB04610
up
CD1A
P06126
Phytosphingosine
HMDB04610
up
CD1B
P29016
Phytosphingosine
HMDB04610
up
CD1C
P29017
Phytosphingosine
HMDB04610
up
CD1D
P15813
Phytosphingosine
HMDB04610
up
CD1E
P15812
Uridine
HMDB00296
down
CDA
P32320
S-Adenosylmethionine
HMDB01185
up
CDK5RAP1
Q96SZ6
S-Adenosylmethionine
HMDB01185
up
CDKAL1
Q5VV42
Adenosine
HMDB00050
down
CECR1
Q9NZK5
palmitic acid
HMDB00220
down
CEL
P19835
L-Carnitine
HMDB00062
up
CES1
P23141
palmitic acid
HMDB00220
down
CES1
P23141
palmitic acid
HMDB00220
down
CES2
O00748
palmitic acid
HMDB00220
down
CES3
Q6UWW8
palmitic acid
HMDB00220
down
CES5A
Q6NT32
Spermine
HMDB01256
up
CHDH
Q8NE62
Spermidine
HMDB01257
up
CHDH
Q8NE62
Spermidine
HMDB01257
up
CHDH
Q8NE62
O-Phosphoethanolamine
HMDB00224
up
CHKA
P35790
Phosphorylcholine
HMDB01565
down
CHKA
P35790
Phosphorylcholine
HMDB01565
up
CHKA
P35790
O-Phosphoethanolamine
HMDB00224
up
CHKB
Q9Y259
Phosphorylcholine
HMDB01565
down
CHKB
Q9Y259
Phosphorylcholine
HMDB01565
up
CHKB
Q9Y259
Creatine
HMDB00064
up
CKB
P12277
Creatine
HMDB00064
up
CKM
P06732
Creatine
HMDB00064
up
CKMT1A
P12532
Creatine
HMDB00064
up
CKMT2
P17540
palmitic acid
HMDB00220
down
CLC
Q05315
S-Adenosylmethionine
HMDB01185
up
CMTR1
Q8N1G2
Histidine
HMDB00177
up
CNDP1
Q96KN2
S-Adenosylmethionine
HMDB01185
up
COMT
P21964
Valine
HMDB00883
up
COMT
P21964
S-Adenosylmethionine
HMDB01185
up
COQ3
Q9NZJ6
S-Adenosylmethionine
HMDB01185
up
COQ5
Q5HYK3
L-Carnitine
HMDB00062
up
CPT1A
P50416
L-Carnitine
HMDB00062
up
CPT1B
Q92523
L-Carnitine
HMDB00062
up
CPT1C
Q8TCG5
L-Carnitine
HMDB00062
up
CPT2
P23786
Phytosphingosine
HMDB04610
up
CPTP
Q5TA50
L-Acetylcarnitine
HMDB00201
up
CRAT
P43155
L-Carnitine
HMDB00062
up
CRAT
P43155
L-Carnitine
HMDB00062
up
CROT
Q9UKG9
Phosphorylcholine
HMDB01565
down
CRP
P02741
Phosphorylcholine
HMDB01565
up
CRP
P02741
Adenosine
HMDB00050
down
DCK
P27707
3-Hydroxykynurenine
HMDB00732
up
DDC
P20711
histamine
HMDB00870
down
DDC
P20711
Histidine
HMDB00177
up
DDC
P20711
Phenylalanine
HMDB00159
up
DDC
P20711
Tyrosine
HMDB00158
up
DDC
P20711
Spermidine
HMDB01257
up
DHPS
P49366
Spermidine
HMDB01257
up
DHPS
P49366
S-Adenosylmethionine
HMDB01185
up
DIMT1
Q9UNQ2
Pseudouridine
HMDB00767
down
DKC1
O60832
Uridine
HMDB00296
down
DKC1
O60832
Spermine
HMDB01256
up
DMGDH
Q9UI17
Spermidine
HMDB01257
up
DMGDH
Q9UI17
Spermidine
HMDB01257
up
DMGDH
Q9UI17
S-Adenosylmethionine
HMDB01185
up
DNMT1
P26358
S-Adenosylmethionine
HMDB01185
up
DNMT3A
Q9Y6K1
S-Adenosylmethionine
HMDB01185
up
DNMT3B
Q9UBC3
S-Adenosylmethionine
HMDB01185
up
DNMT3L
Q9UJW3
Lysine
HMDB00182
up
DOT1L
Q8TEK3
S-Adenosylmethionine
HMDB01185
up
DOT1L
Q8TEK3
S-Adenosylmethionine
HMDB01185
up
DPH5
Q9H2P9
thymine
HMDB00262
up
DPYD
Q12882
Uracil
HMDB00300
up
DPYD
Q12882
Tyrosine
HMDB00158
up
EGFR
P00533
Lysine
HMDB00182
up
EHMT1
Q9H9B1
S-Adenosylmethionine
HMDB01185
up
EHMT1
Q9H9B1
Lysine
HMDB00182
up
EHMT2
Q96KQ7
S-Adenosylmethionine
HMDB01185
up
EHMT2
Q96KQ7
S-Adenosylmethionine
HMDB01185
up
ELP3
Q9H9T3
Phosphorylcholine
HMDB01565
down
ELSPBP1
Q96BH3
Phosphorylcholine
HMDB01565
up
ELSPBP1
Q96BH3
S-Adenosylmethionine
HMDB01185
up
EMG1
Q92979
O-Phosphoethanolamine
HMDB00224
up
ENPP6
Q6UWR7
Phosphorylcholine
HMDB01565
down
ENPP6
Q6UWR7
Phosphorylcholine
HMDB01565
up
ENPP6
Q6UWR7
Phosphorylcholine
HMDB01565
down
ENPP7
Q6UWV6
Phosphorylcholine
HMDB01565
up
ENPP7
Q6UWV6
Phenylalanine
HMDB00159
up
EPX
P11678
O-Phosphoethanolamine
HMDB00224
up
ETNK1
Q9HBU6
O-Phosphoethanolamine
HMDB00224
up
ETNK2
Q9NVF9
O-Phosphoethanolamine
HMDB00224
up
ETNPPL
Q8TBG4
S-Adenosylmethionine
HMDB01185
up
EZH1
Q92800
Lysine
HMDB00182
up
EZH2
Q15910
S-Adenosylmethionine
HMDB01185
up
EZH2
Q15910
Phenylalanine
HMDB00159
up
FARS2
O95363
Phenylalanine
HMDB00159
up
FARSA
Q9Y285
Phenylalanine
HMDB00159
up
FARSB
Q9NSD9
palmitic acid
HMDB00220
down
FASN
P49327
S-Adenosylmethionine
HMDB01185
up
FBL
P22087
S-Adenosylmethionine
HMDB01185
up
FBLL1
A6NHQ2
Tyrosine
HMDB00158
up
FGFR1
P11362
S-Adenosylmethionine
HMDB01185
up
FTSJ1
Q9UET6
S-Adenosylmethionine
HMDB01185
up
FTSJ2
Q9UI43
S-Adenosylmethionine
HMDB01185
up
FTSJ3
Q8IY81
Guanidoacetic acid
HMDB00128
down
GAMT
Q14353
Creatine
HMDB00064
up
GAMT
Q14353
S-Adenosylmethionine
HMDB01185
up
GAMT
Q14353
Guanidoacetic acid
HMDB00128
down
GATM
P50440
Spermine
HMDB01256
up
GATM
P50440
Creatine
HMDB00064
up
GATM
P50440
Spermidine
HMDB01257
up
GATM
P50440
Spermidine
HMDB01257
up
GATM
P50440
Phytosphingosine
HMDB04610
up
GBA2
Q9HCG7
Phytosphingosine
HMDB04610
up
GBGT1
Q8N5D6
guanine
HMDB00132
up
GCH1
P30793
guanine
HMDB00132
up
GDA
Q9Y2T3
Pyroglutamic acid
HMDB00267
up
GGCT
O75223
Phytosphingosine
HMDB04610
up
GLTP
Q9NZD2
Phytosphingosine
HMDB04610
up
GLTPD2
A6NH11
Hippuric acid
HMDB00714
down
GLYAT
Q6IB77
N-Acryloylglycine
HMDB01843
up
GLYAT
Q6IB77
Hippuric acid
HMDB00714
down
GLYATL1
Q969I3
N-Acryloylglycine
HMDB01843
up
GLYATL1
Q969I3
Hippuric acid
HMDB00714
down
GLYATL2
Q8WU03
N-Acryloylglycine
HMDB01843
up
GLYATL2
Q8WU03
Hippuric acid
HMDB00714
down
GLYATL3
Q5SZD4
N-Acryloylglycine
HMDB01843
up
GLYATL3
Q5SZD4
Phytosphingosine
HMDB04610
up
GM2A
P17900
guanine
HMDB00132
up
GNAI1
P63096
guanine
HMDB00132
up
GNAQ
P50148
guanine
HMDB00132
up
GNAS
P63092
S-Adenosylmethionine
HMDB01185
up
GNMT
Q14749
Phenylalanine
HMDB00159
up
GOT1
P17174
Tyrosine
HMDB00158
up
GOT1
P17174
Kynurenine
HMDB00684
up
GOT2
P00505
Phenylalanine
HMDB00159
up
GOT2
P00505
Tyrosine
HMDB00158
up
GOT2
P00505
Phytosphingosine
HMDB04610
up
GPAA1
O43292
Uracil
HMDB00300
up
GPR17
Q13304
D-Lactate
HMDB01311
up
HAGH
Q16775
D-Lactate
HMDB01311
up
HAGHL
Q6PII5
Histidine
HMDB00177
up
HAL
P42357
Histidine
HMDB00177
up
HARS
P12081
Histidine
HMDB00177
up
HARS2
P49590
Pyroglutamic acid
HMDB00267
up
HCRT
O43612
Spermine
HMDB01256
up
HDC
P19113
histamine
HMDB00870
down
HDC
P19113
Histidine
HMDB00177
up
HDC
P19113
Spermidine
HMDB01257
up
HDC
P19113
Spermidine
HMDB01257
up
HDC
P19113
Pseudouridine
HMDB00767
down
HDHD1
Q08623
Histidine
HMDB00177
up
HEMK1
Q9Y5R4
S-Adenosylmethionine
HMDB01185
up
HEMK1
Q9Y5R4
S-Adenosylmethionine
HMDB01185
up
HENMT1
Q5T8I9
palmitic acid
HMDB00220
down
HIPK1
Q86Z02
histamine
HMDB00870
down
HNMT
P50135
S-Adenosylmethionine
HMDB01185
up
HNMT
P50135
guanine
HMDB00132
up
HPRT1
P00492
Hypoxanthine
HMDB00157
up
HPRT1
P00492
O-Phosphoethanolamine
HMDB00224
up
HRASLS2
Q9NWW9
histamine
HMDB00870
down
HRH1
P35367
histamine
HMDB00870
down
HRH2
P25021
histamine
HMDB00870
down
HRH3
Q9Y5N1
histamine
HMDB00870
down
HRH4
Q9H3N8
S-Adenosylmethionine
HMDB01185
up
ICMT
O60725
Creatine
HMDB00064
up
ID3
Q02535
Pyroglutamic acid
HMDB00267
up
IGLC1
P0CG04
Phenylalanine
HMDB00159
up
IL4I1
Q96RQ9
Tyrosine
HMDB00158
up
IL4I1
Q96RQ9
S-Adenosylmethionine
HMDB01185
up
INMT
O95050
Tyrosine
HMDB00158
up
IYD
Q6PHW0
Lysine
HMDB00182
up
KARS
Q15046
Lysine
HMDB00182
up
KDM2A
Q9Y2K7
Lysine
HMDB00182
up
KDM2B
Q8NHM5
3-Hydroxykynurenine
HMDB00732
up
KMO
O15229
Kynurenine
HMDB00684
up
KMO
O15229
Lysine
HMDB00182
up
KMT2A
Q03164
S-Adenosylmethionine
HMDB01185
up
KMT2A
Q03164
Lysine
HMDB00182
up
KMT2B
Q9UMN6
S-Adenosylmethionine
HMDB01185
up
KMT2B
Q9UMN6
Lysine
HMDB00182
up
KMT2C
Q8NEZ4
S-Adenosylmethionine
HMDB01185
up
KMT2C
Q8NEZ4
Lysine
HMDB00182
up
KMT2D
O14686
S-Adenosylmethionine
HMDB01185
up
KMT2D
O14686
S-Adenosylmethionine
HMDB01185
up
KMT2E
Q8IZD2
3-Hydroxykynurenine
HMDB00732
up
KYNU
Q16719
Kynurenine
HMDB00684
up
KYNU
Q16719
Phytosphingosine
HMDB04610
up
LBP
P18428
S-Adenosylmethionine
HMDB01185
up
LCMT1
Q9UIC8
S-Adenosylmethionine
HMDB01185
up
LCMT2
O60294
L-Lactate
HMDB00190
up
LDHA
P00338
L-Lactate
HMDB00190
up
LDHAL6A
Q6ZMR3
L-Lactate
HMDB00190
up
LDHAL6B
Q9BYZ2
L-Lactate
HMDB00190
up
LDHB
P07195
L-Lactate
HMDB00190
up
LDHC
P07864
D-Lactate
HMDB01311
up
LDHD
Q86WU2
palmitic acid
HMDB00220
down
LGALS13
Q9UHV8
S-Adenosylmethionine
HMDB01185
up
LIAS
O43766
palmitic acid
HMDB00220
down
LIPC
P11150
palmitic acid
HMDB00220
down
LIPE
Q05469
palmitic acid
HMDB00220
down
LIPF
P07098
palmitic acid
HMDB00220
down
LIPG
Q9Y5X9
palmitic acid
HMDB00220
down
LPL
P06858
Phenylalanine
HMDB00159
up
LPO
P22079
S-Adenosylmethionine
HMDB01185
up
LRTOMT
Q8WZ04
palmitic acid
HMDB00220
down
LYPLA1
O75608
palmitic acid
HMDB00220
down
LYPLA2
O95372
S-Adenosylmethionine
HMDB01185
up
MAT1A
Q00266
S-Adenosylmethionine
HMDB01185
up
MAT2A
P31153
S-Adenosylmethionine
HMDB01185
up
MAT2B
Q9NZL9
Cytosine
HMDB00630
up
MBD1
Q9UIS9
Cytosine
HMDB00630
up
MBD2
Q9UBB5
S-Adenosylmethionine
HMDB01185
up
MEPCE
Q7L2J0
S-Adenosylmethionine
HMDB01185
up
METTL1
Q9UBP6
S-Adenosylmethionine
HMDB01185
up
METTL11B
Q5VVY1
S-Adenosylmethionine
HMDB01185
up
METTL15
A6NJ78
S-Adenosylmethionine
HMDB01185
up
METTL15P1
P0C7V9
Histidine
HMDB00177
up
METTL2B
Q6P1Q9
S-Adenosylmethionine
HMDB01185
up
METTL2B
Q6P1Q9
S-Adenosylmethionine
HMDB01185
up
METTL3
Q86U44
Histidine
HMDB00177
up
METTL6
Q8TCB7
S-Adenosylmethionine
HMDB01185
up
METTL6
Q8TCB7
S-Adenosylmethionine
HMDB01185
up
MOCS1
Q9NZB8
L-Carnitine
HMDB00062
up
MPO
P05164
Phenylalanine
HMDB00159
up
MPO
P05164
Spermine
HMDB01256
up
MTAP
Q13126
Spermidine
HMDB01257
up
MTAP
Q13126
Spermidine
HMDB01257
up
MTAP
Q13126
S-Adenosylmethionine
HMDB01185
up
MTR
Q99707
S-Adenosylmethionine
HMDB01185
up
MTRR
Q9UBK8
2,6 Dimethylheptanoyl carnitine
HMDB06320
down
N/A
N/A
3-Amino-2-piperidone
HMDB00323
up
N/A
N/A
Alpha-N-Phenylacetyl-L-glutamine
HMDB06344
down
N/A
N/A
Arachidonate
HMDB60102
up
N/A
N/A
Dihydrolipoate
HMDB12210
down
N/A
N/A
L-leucyl-L-proline
HMDB11175
down
N/A
N/A
Palmitoyl sphingomyelin
HMDB61712
up
N/A
N/A
Trigonelline
HMDB00875
down
N/A
N/A
S-Adenosylmethionine
HMDB01185
up
NNMT
P40261
Phytosphingosine
HMDB04610
up
NPC2
P61916
Lysine
HMDB00182
up
NSD1
Q96L73
S-Adenosylmethionine
HMDB01185
up
NSD1
Q96L73
S-Adenosylmethionine
HMDB01185
up
NSUN2
Q08J23
S-Adenosylmethionine
HMDB01185
up
NSUN3
Q9H649
S-Adenosylmethionine
HMDB01185
up
NSUN4
Q96CB9
S-Adenosylmethionine
HMDB01185
up
NSUN5P2
Q63ZY6
S-Adenosylmethionine
HMDB01185
up
NSUN5P2
Q96P11
S-Adenosylmethionine
HMDB01185
up
NSUN6
Q8TEA1
S-Adenosylmethionine
HMDB01185
up
NSUN7
Q8NE18
Adenosine
HMDB00050
down
NT5C
Q8TCD5
Uridine
HMDB00296
down
NT5C
Q8TCD5
Adenosine
HMDB00050
down
NT5C1A
Q9BXI3
Uridine
HMDB00296
down
NT5C1A
Q9BXI3
Adenosine
HMDB00050
down
NT5C1B
Q96P26
Uridine
HMDB00296
down
NT5C1B
Q96P26
Adenosine
HMDB00050
down
NT5C2
P49902
Uridine
HMDB00296
down
NT5C2
P49902
Adenosine
HMDB00050
down
NT5C3A
Q9H0P0
Uridine
HMDB00296
down
NT5C3A
Q9H0P0
Adenosine
HMDB00050
down
NT5E
P21589
Uridine
HMDB00296
down
NT5E
P21589
Adenosine
HMDB00050
down
NT5M
Q9NPB1
Uridine
HMDB00296
down
NT5M
Q9NPB1
S-Adenosylmethionine
HMDB01185
up
NTMT1
Q9BV86
Spermidine
HMDB01257
up
OAZ1
P54368
Spermidine
HMDB01257
up
OAZ1
P54368
Spermine
HMDB01256
up
OAZ1
P54368
Spermine
HMDB01256
up
ODC1
P11926
Spermidine
HMDB01257
up
ODC1
P11926
Spermidine
HMDB01257
up
ODC1
P11926
palmitic acid
HMDB00220
down
OLAH
Q9NV23
Pyroglutamic acid
HMDB00267
up
OPLAH
O14841
Phenylalanine
HMDB00159
up
PAH
P00439
Tyrosine
HMDB00158
up
PAH
P00439
N12-Diacetylspermine
HMDB02172
up
PAOX
Q6QHF9
Spermidine
HMDB01257
up
PAOX
Q6QHF9
Spermidine
HMDB01257
up
PAOX
Q6QHF9
Spermidine
HMDB01257
up
PCCA
P05165
Spermidine
HMDB01257
up
PCCA
P05165
Valine
HMDB00883
up
PCCB
P05166
S-Adenosylmethionine
HMDB01185
up
PCMT1
P22061
Phosphorylcholine
HMDB01565
down
PCYT1A
P49585
Phosphorylcholine
HMDB01565
up
PCYT1A
P49585
Phosphorylcholine
HMDB01565
down
PCYT1B
Q9Y5K3
Phosphorylcholine
HMDB01565
up
PCYT1B
Q9Y5K3
O-Phosphoethanolamine
HMDB00224
up
PCYT2
Q99447
Spermidine
HMDB01257
up
PDPR
Q8NCN5
Spermidine
HMDB01257
up
PDPR
Q8NCN5
Spermine
HMDB01256
up
PDPR
Q8NCN5
S-Adenosylmethionine
HMDB01185
up
PEMT
Q9UBM1
O-Phosphoethanolamine
HMDB00224
up
PHOSPHO1
Q8TCT1
Phosphorylcholine
HMDB01565
down
PHOSPHO1
Q8TCT1
Phosphorylcholine
HMDB01565
up
PHOSPHO1
Q8TCT1
Phytosphingosine
HMDB04610
up
PIGA
P37287
Phytosphingosine
HMDB04610
up
PIGB
Q92521
Phytosphingosine
HMDB04610
up
PIGC
Q92535
Phytosphingosine
HMDB04610
up
PIGF
Q07326
Phytosphingosine
HMDB04610
up
PIGG
Q5H8A4
Phytosphingosine
HMDB04610
up
PIGH
Q14442
Phytosphingosine
HMDB04610
up
PIGK
Q92643
Phytosphingosine
HMDB04610
up
PIGL
Q9Y2B2
Phytosphingosine
HMDB04610
up
PIGM
Q9H3S5
Phytosphingosine
HMDB04610
up
PIGN
O95427
Phytosphingosine
HMDB04610
up
PIGO
Q8TEQ8
Phytosphingosine
HMDB04610
up
PIGP
P57054
Phytosphingosine
HMDB04610
up
PIGQ
Q9BRB3
Phytosphingosine
HMDB04610
up
PIGS
Q96S52
Phytosphingosine
HMDB04610
up
PIGT
Q969N2
Phytosphingosine
HMDB04610
up
PIGU
Q9H490
Phytosphingosine
HMDB04610
up
PIGV
Q9NUD9
Phytosphingosine
HMDB04610
up
PIGW
Q7Z7B1
Phytosphingosine
HMDB04610
up
PIGX
Q8TBF5
Phytosphingosine
HMDB04610
up
PIGY
Q3MUY2
Phytosphingosine
HMDB04610
up
PIGZ
Q86VD9
palmitic acid
HMDB00220
down
PLA2G10
O15496
palmitic acid
HMDB00220
down
PLA2G12A
Q9BZM1
palmitic acid
HMDB00220
down
PLA2G1B
P04054
palmitic acid
HMDB00220
down
PLA2G2A
P14555
palmitic acid
HMDB00220
down
PLA2G2D
Q9UNK4
palmitic acid
HMDB00220
down
PLA2G2E
Q9NZK7
palmitic acid
HMDB00220
down
PLA2G2F
Q9BZM2
palmitic acid
HMDB00220
down
PLA2G3
Q9NZ20
palmitic acid
HMDB00220
down
PLA2G4A
P47712
palmitic acid
HMDB00220
down
PLA2G4B
P0C869
palmitic acid
HMDB00220
down
PLA2G4C
Q9UP65
palmitic acid
HMDB00220
down
PLA2G4D
Q86XP0
palmitic acid
HMDB00220
down
PLA2G4E
Q3MJ16
palmitic acid
HMDB00220
down
PLA2G4F
Q68DD2
palmitic acid
HMDB00220
down
PLA2G5
P39877
palmitic acid
HMDB00220
down
PLA2G6
O60733
palmitic acid
HMDB00220
down
PLB1
Q6P1J6
Phytosphingosine
HMDB04610
up
PLEKHA8
B5MDU3
Phytosphingosine
HMDB04610
up
PLEKHA8
Q96JA3
Phytosphingosine
HMDB04610
up
PLEKHA8P1
O95397
Lysine
HMDB00182
up
PLOD1
Q02809
Lysine
HMDB00182
up
PLOD2
O00469
Lysine
HMDB00182
up
PLOD3
O60568
Spermidine
HMDB01257
up
PMF1
Q6P1K2
Spermidine
HMDB01257
up
PMF1
Q6P1K2
Spermine
HMDB01256
up
PMF1
Q6P1K2
palmitic acid
HMDB00220
down
PNLIP
P16233
palmitic acid
HMDB00220
down
PNLIPRP1
P54315
palmitic acid
HMDB00220
down
PNLIPRP2
P54317
palmitic acid
HMDB00220
down
PNLIPRP3
Q17RR3
S-Adenosylmethionine
HMDB01185
up
PNMT
P11086
guanine
HMDB00132
up
PNP
P00491
Hypoxanthine
HMDB00157
up
PNP
P00491
Uracil
HMDB00300
up
PNP
P00491
Adenosine
HMDB00050
down
PNP
P00491
palmitic acid
HMDB00220
down
PNPLA2
Q96AD5
palmitic acid
HMDB00220
down
PNPLA3
Q9NST1
palmitic acid
HMDB00220
down
PNPLA4
P41247
palmitic acid
HMDB00220
down
PNPLA6
Q8IY17
palmitic acid
HMDB00220
down
PNPLA8
Q9NP80
palmitic acid
HMDB00220
down
PPARG
P37231
palmitic acid
HMDB00220
down
PPT1
P50897
palmitic acid
HMDB00220
down
PPT2
Q9UMR5
Lysine
HMDB00182
up
PRDM2
Q13029
S-Adenosylmethionine
HMDB01185
up
PRDM2
Q13029
S-Adenosylmethionine
HMDB01185
up
PRDM6
Q9NQX0
S-Adenosylmethionine
HMDB01185
up
PRDM7
Q9NQW5
S-Adenosylmethionine
HMDB01185
up
PRDM9
Q9NQV7
Phenylalanine
HMDB00159
up
PRDX6
P30041
S-Adenosylmethionine
HMDB01185
up
PRMT1
Q99873
S-Adenosylmethionine
HMDB01185
up
PRMT2
P55345
Histidine
HMDB00177
up
PRMT3
O60678
S-Adenosylmethionine
HMDB01185
up
PRMT5
O14744
S-Adenosylmethionine
HMDB01185
up
PRMT6
Q96LA8
S-Adenosylmethionine
HMDB01185
up
PRMT7
Q9NVM4
Creatine
HMDB00064
up
PRRX1
P54821
Pseudouridine
HMDB00767
down
PUS1
Q9Y606
Uridine
HMDB00296
down
PUS1
Q9Y606
Pseudouridine
HMDB00767
down
PUS10
Q3MIT2
Uridine
HMDB00296
down
PUS10
Q3MIT2
Pseudouridine
HMDB00767
down
PUS3
Q9BZE2
Uridine
HMDB00296
down
PUS3
Q9BZE2
Pseudouridine
HMDB00767
down
PUS7
Q96PZ0
Pseudouridine
HMDB00767
down
PUS7L
Q9H0K6
Pseudouridine
HMDB00767
down
PUSL1
Q8N0Z8
Uridine
HMDB00296
down
PUSL1
Q8N0Z8
Pyroglutamic acid
HMDB00267
up
QPCT
Q16769
guanine
HMDB00132
up
QTRT1
Q9BXR0
guanine
HMDB00132
up
QTRTD1
Q9H974
S-Adenosylmethionine
HMDB01185
up
RNMT
O43148
Pseudouridine
HMDB00767
down
RPUSD1
Q9UJJ7
Pseudouridine
HMDB00767
down
RPUSD2
Q8IZ73
Pseudouridine
HMDB00767
down
RPUSD3
Q6P087
Pseudouridine
HMDB00767
down
RPUSD4
Q96CM3
S-Adenosylmethionine
HMDB01185
up
RSAD1
Q9HA92
S-Adenosylmethionine
HMDB01185
up
RSAD2
Q8WXG1
Spermidine
HMDB01257
up
SARDH
Q9UL12
Spermidine
HMDB01257
up
SARDH
Q9UL12
Spermine
HMDB01256
up
SARDH
Q9UL12
Spermidine
HMDB01257
up
SAT1
P21673
Spermidine
HMDB01257
up
SAT1
P21673
Spermine
HMDB01256
up
SAT1
P21673
Spermine
HMDB01256
up
SAT2
Q96F10
S-Adenosylmethionine
HMDB01185
up
SETD1A
O15047
S-Adenosylmethionine
HMDB01185
up
SETD1B
Q9UPS6
Lysine
HMDB00182
up
SETD2
Q9BYW2
S-Adenosylmethionine
HMDB01185
up
SETD2
Q9BYW2
S-Adenosylmethionine
HMDB01185
up
SETD3
Q86TU7
Lysine
HMDB00182
up
SETD7
Q8WTS6
S-Adenosylmethionine
HMDB01185
up
SETD7
Q8WTS6
S-Adenosylmethionine
HMDB01185
up
SETD8
Q9NQR1
Lysine
HMDB00182
up
SETDB1
Q15047
S-Adenosylmethionine
HMDB01185
up
SETDB1
Q15047
S-Adenosylmethionine
HMDB01185
up
SETDB2
Q96T68
S-Adenosylmethionine
HMDB01185
up
SETMAR
Q53H47
O-Phosphoethanolamine
HMDB00224
up
SGPL1
O95470
D-Lactate
HMDB01311
up
SLC16A1
P53985
Histidine
HMDB00177
up
SLC16A10
Q8TF71
Phenylalanine
HMDB00159
up
SLC16A10
Q8TF71
Tyrosine
HMDB00158
up
SLC16A10
Q8TF71
Valine
HMDB00883
up
SLC16A10
Q8TF71
Tyrosine
HMDB00158
up
SLC16A2
P36021
D-Lactate
HMDB01311
up
SLC16A3
O15427
D-Lactate
HMDB01311
up
SLC16A7
O60669
histamine
HMDB00870
down
SLC18A2
Q05940
Spermidine
HMDB01257
up
SLC22A1
O15245
Spermidine
HMDB01257
up
SLC22A1
O15245
Spermine
HMDB01256
up
SLC22A1
O15245
L-Carnitine
HMDB00062
up
SLC22A16
Q86VW1
L-Carnitine
HMDB00062
up
SLC22A4
Q9H015
Spermidine
HMDB01257
up
SLC22A4
Q9H015
Spermidine
HMDB01257
up
SLC22A4
Q9H015
Spermine
HMDB01256
up
SLC22A4
Q9H015
L-Carnitine
HMDB00062
up
SLC22A5
O76082
L-Acetylcarnitine
HMDB00201
up
SLC25A20
O43772
L-Carnitine
HMDB00062
up
SLC25A20
O43772
S-Adenosylmethionine
HMDB01185
up
SLC25A26
Q70HW3
L-Carnitine
HMDB00062
up
SLC25A29
Q8N8R3
palmitic acid
HMDB00220
down
SLC27A1
Q6PCB7
palmitic acid
HMDB00220
down
SLC27A3
Q5K4L6
palmitic acid
HMDB00220
down
SLC27A4
Q6P1M0
palmitic acid
HMDB00220
down
SLC27A6
Q9Y2P4
Hypoxanthine
HMDB00157
up
SLC29A2
Q14542
Adenosine
HMDB00050
down
SLC35B2
Q8TB61
Adenosine
HMDB00050
down
SLC35B3
Q9H1N7
Histidine
HMDB00177
up
SLC38A3
Q99624
Creatine
HMDB00064
up
SLC6A8
P48029
Phenylalanine
HMDB00159
up
SLC7A8
Q9UHI5
L-Carnitine
HMDB00062
up
SLCO1B1
Q9Y6L6
Spermidine
HMDB01257
up
SMOX
Q9NWM0
Spermidine
HMDB01257
up
SMOX
Q9NWM0
Spermine
HMDB01256
up
SMOX
Q9NWM0
Phosphorylcholine
HMDB01565
down
SMPD1
P17405
Phosphorylcholine
HMDB01565
up
SMPD1
P17405
Phosphorylcholine
HMDB01565
down
SMPD2
O60906
Phosphorylcholine
HMDB01565
up
SMPD2
O60906
Phosphorylcholine
HMDB01565
down
SMPD3
Q9NY59
Phosphorylcholine
HMDB01565
up
SMPD3
Q9NY59
Phosphorylcholine
HMDB01565
down
SMPD4
Q9NXE4
Phosphorylcholine
HMDB01565
up
SMPD4
Q9NXE4
Spermidine
HMDB01257
up
SMS
P52788
Spermidine
HMDB01257
up
SMS
P52788
Spermine
HMDB01256
up
SMS
P52788
S-Adenosylmethionine
HMDB01185
up
SMYD2
Q9NRG4
S-Adenosylmethionine
HMDB01185
up
SMYD3
Q9H7B4
Spermidine
HMDB01257
up
SRM
P19623
Spermidine
HMDB01257
up
SRM
P19623
Spermine
HMDB01256
up
SRM
P19623
S-Adenosylmethionine
HMDB01185
up
SUV39H1
O43463
S-Adenosylmethionine
HMDB01185
up
SUV39H2
Q9H5I1
S-Adenosylmethionine
HMDB01185
up
SUV420H1
Q4FZB7
S-Adenosylmethionine
HMDB01185
up
SUV420H2
Q86Y97
S-Adenosylmethionine
HMDB01185
up
TARBP1
Q13395
Phenylalanine
HMDB00159
up
TAT
P17735
Tyrosine
HMDB00158
up
TAT
P17735
S-Adenosylmethionine
HMDB01185
up
TFB1M
Q8WVM0
S-Adenosylmethionine
HMDB01185
up
TFB2M
Q9H5Q4
S-Adenosylmethionine
HMDB01185
up
TGS1
Q96RS0
Phenylalanine
HMDB00159
up
TH
P07101
Tyrosine
HMDB00158
up
TH
P07101
palmitic acid
HMDB00220
down
THEM4
Q5T1C6
palmitic acid
HMDB00220
down
THEM5
Q8N1Q8
Spermidine
HMDB01257
up
TMLHE
Q9NVH6
Spermidine
HMDB01257
up
TMLHE
Q9NVH6
Spermine
HMDB01256
up
TMLHE
Q9NVH6
S-Adenosylmethionine
HMDB01185
up
TPMT
P51580
Tyrosine
HMDB00158
up
TPO
P07202
S-Adenosylmethionine
HMDB01185
up
TRDMT1
O14717
S-Adenosylmethionine
HMDB01185
up
TRMT11
Q7Z4G4
S-Adenosylmethionine
HMDB01185
up
TRMT11
Q9NXH9
S-Adenosylmethionine
HMDB01185
up
TRMT12
Q53H54
S-Adenosylmethionine
HMDB01185
up
TRMT13
Q9NUP7
S-Adenosylmethionine
HMDB01185
up
TRMT2B
Q96GJ1
S-Adenosylmethionine
HMDB01185
up
TRMT44
Q8IYL2
S-Adenosylmethionine
HMDB01185
up
TRMT5
Q32P41
S-Adenosylmethionine
HMDB01185
up
TRMT61A
Q96FX7
S-Adenosylmethionine
HMDB01185
up
TRMT61B
Q9BVS5
S-Adenosylmethionine
HMDB01185
up
TRMU
O75648
Pseudouridine
HMDB00767
down
TRUB1
Q8WWH5
Pseudouridine
HMDB00767
down
TRUB2
O95900
Tyrosine
HMDB00158
up
TTL
Q8NG68
Spermidine
HMDB01257
up
TXNRD1
Q16881
Spermidine
HMDB01257
up
TXNRD1
Q16881
thymine
HMDB00262
up
TYMP
P19971
Uracil
HMDB00300
up
TYMP
P19971
Tyrosine
HMDB00158
up
TYR
P14679
S-Adenosylmethionine
HMDB01185
up
TYW1
Q9NV66
S-Adenosylmethionine
HMDB01185
up
TYW1B
Q6NUM6
S-Adenosylmethionine
HMDB01185
up
TYW3
Q6IPR3
Uridine
HMDB00296
down
UCK1
Q9HA47
Uridine
HMDB00296
down
UCK2
Q9BZX2
Uracil
HMDB00300
up
UCKL1
Q9NWZ5
Uridine
HMDB00296
down
UCKL1
Q9NWZ5
Uracil
HMDB00300
up
UPP1
Q16831
Uridine
HMDB00296
down
UPP1
Q16831
Uracil
HMDB00300
up
UPP2
O95045
Uridine
HMDB00296
down
UPP2
O95045
Uracil
HMDB00300
up
UPRT
Q96BW1
Valine
HMDB00883
up
VARS
P26640
Valine
HMDB00883
up
VARS2
Q5ST30
Pyroglutamic acid
HMDB00267
up
VEGFA
P15692
Histidine
HMDB00177
up
WBSCR22
O43709
S-Adenosylmethionine
HMDB01185
up
WBSCR22
O43709
Lysine
HMDB00182
up
WHSC1
O96028
S-Adenosylmethionine
HMDB01185
up
WHSC1
O96028
Lysine
HMDB00182
up
WHSC1L1
Q9BZ95
S-Adenosylmethionine
HMDB01185
up
WHSC1L1
Q9BZ95
Hypoxanthine
HMDB00157
up
XDH
P47989
L-Carnitine
HMDB00062
up
XDH
P47989
Spermine
HMDB01256
up
XDH
P47989
Tyrosine
HMDB00158
up
YARS
P54577
Tyrosine
HMDB00158
up
YARS2
Q9Y2Z4
histamine
HMDB00870
down
ZNF219
Q9P2Y4


Marie