Examples


DNA Mutations

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All molecules displayed are selected based on the significance criteria.

Gene name
UniProt Acc. No.
Protein Name
Type of Mutation
Comparison
PMID
AKT1
P31749
RAC-alpha serine/threonine-protein kinase
point mutation
Ta,T1 VS T2,T3,T4
25533674
APC
P25054
Adenomatous polyposis coli protein
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
ARID1A
O14497
AT-rich interactive domain-containing protein 1A
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
ARID1A
O14497
AT-rich interactive domain-containing protein 1A
null mutation
N VS T2-T4
24476821
ARID1A
O14497
AT-rich interactive domain-containing protein 1A
point mutation
N VS T2-T4
24476821
ATM
Q13315
Serine-protein kinase ATM
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
BTG2
P78543
Protein BTG2
null mutation
N VS T2-T4
24476821
BTG2
P78543
Protein BTG2
point mutation
N VS T2-T4
24476821
CCND1
P24385
G1/S-specific cyclin-D1
amplification
Ta,T1 VS T2,T3,T4
25533674
CCND3
P30281
G1/S-specific cyclin-D3
null mutation
N VS T2-T4
24476821
CCND3
P30281
G1/S-specific cyclin-D3
point mutation
N VS T2-T4
24476821
CDKN1A
P38936
Cyclin-dependent kinase inhibitor 1
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
CDKN1A
P38936
Cyclin-dependent kinase inhibitor 1
null mutation
N VS T2-T4
24476821
CDKN1A
P38936
Cyclin-dependent kinase inhibitor 1
point mutation
N VS T2-T4
24476821
CDKN2A
P42771
Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
hemizygous deletion
Ta,T1 VS T2,T3,T4
25533674
CDKN2A
P42771
Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
homozygous deletion
Ta,T1 VS T2,T3,T4
25533674
CDKN2A
P42771
Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
mutation
Ta,T1 VS T2,T3,T4
25533674
CDKN2A
P42771
Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
null mutation
N VS T2-T4
24476821
CDKN2A
P42771
Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
point mutation
N VS T2-T4
24476821
CTNNB1
P35222
Catenin beta-1
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
E2F3
O00716
Transcription factor E2F3
amplification
Ta,T1 VS T2,T3,T4
25533674
ELF3
P78545
ETS-related transcription factor Elf-3
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
ELF3
P78545
ETS-related transcription factor Elf-3
null mutation
N VS T2-T4
24476821
ELF3
P78545
ETS-related transcription factor Elf-3
point mutation
N VS T2-T4
24476821
EP300
Q09472
Histone acetyltransferase p300
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
EP300
Q09472
Histone acetyltransferase p300
null mutation
N VS T2-T4
24476821
EP300
Q09472
Histone acetyltransferase p300
point mutation
N VS T2-T4
24476821
ERBB2
P04626
Receptor tyrosine-protein kinase erbB-2
amplification
Ta,T1 VS T2,T3,T4
25533674
ERBB2
P04626
Receptor tyrosine-protein kinase erbB-2
mutation
Ta,T1 VS T2,T3,T4
25533674
ERBB3
P21860
Receptor tyrosine-protein kinase erbB-3
null mutation
N VS T2-T4
24476821
ERBB3
P21860
Receptor tyrosine-protein kinase erbB-3
point mutation
N VS T2-T4
24476821
ERBB3
P21860
Receptor tyrosine-protein kinase erbB-3
point mutation
Ta,T1 VS T2,T3,T4
25533674
ERCC2
P18074
TFIIH basal transcription factor complex helicase XPD subunit
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
ERCC2
P18074
TFIIH basal transcription factor complex helicase XPD subunit
point mutation
N VS T2-T4
24476821
FBXW7
Q969H0
F-box/WD repeat-containing protein 7
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
FBXW7
Q969H0
F-box/WD repeat-containing protein 7
null mutation
N VS T2-T4
24476821
FBXW7
Q969H0
F-box/WD repeat-containing protein 7
point mutation
N VS T2-T4
24476821
FGFR1
P11362
Fibroblast growth factor receptor 1
amplification
Ta,T1 VS T2,T3,T4
25533674
FGFR3
P22607
Fibroblast growth factor receptor 3
point mutation
Ta,T1 VS T2,T3,T4
25533674
FGFR3
P22607
Fibroblast growth factor receptor 3
point mutation
N VS T2-T4
24476821
FOXA1
P55317
Hepatocyte nuclear factor 3-alpha
null mutation
N VS T2-T4
24476821
FOXA1
P55317
Hepatocyte nuclear factor 3-alpha
point mutation
N VS T2-T4
24476821
FOXQ1
Q9C009
Forkhead box protein Q1
null mutation
N VS T2-T4
24476821
FOXQ1
Q9C009
Forkhead box protein Q1
point mutation
N VS T2-T4
24476821
GPC5
P78333
Glypican-5
null mutation
N VS T2-T4
24476821
GPC5
P78333
Glypican-5
point mutation
N VS T2-T4
24476821
HORMAD1
Q86X24
HORMA domain-containing protein 1
point mutation
N VS T2-T4
24476821
HORMAD1
Q86X24
HORMA domain-containing protein 1
null mutation
N VS T2-T4
24476821
HRAS
P01112
GTPase Hras
point mutation
Ta,T1 VS T2,T3,T4
25533674
HRAS
P01112
GTPase Hras
point mutation
N VS T2-T4
24476821
KDM6A
O15550
Lysine-specific demethylase 6A
null mutation
N VS T2-T4
24476821
KDM6A
O15550
Lysine-specific demethylase 6A
point mutation
N VS T2-T4
24476821
KDM6A
O15550
Lysine-specific demethylase 6A
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
KLF5
Q13887
Krueppel-like factor 5
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
KLF5
Q13887
Krueppel-like factor 5
point mutation
N VS T2-T4
24476821
KLF5
Q13887
Krueppel-like factor 5
null mutation
N VS T2-T4
24476821
KMT2D
O14686
Histone-lysine N-methyltransferase 2D
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
KMT2D
O14686
Histone-lysine N-methyltransferase 2D
null mutation
N VS T2-T4
24476821
KMT2D
O14686
Histone-lysine N-methyltransferase 2D
point mutation
N VS T2-T4
24476821
KRAS
P01116
GTPase Kras
point mutation
Ta,T1 VS T2,T3,T4
25533674
MDM2
Q00987
E3 ubiquitin-protein ligase Mdm2
amplification
Ta,T1 VS T2,T3,T4
25533674
MDM2
Q00987
E3 ubiquitin-protein ligase Mdm2
amplification
Ta,T1 VS T2,T3,T4
25533674
NFE2L2
Q16236
Nuclear factor erythroid 2-related factor 2
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
NFE2L2
Q16236
Nuclear factor erythroid 2-related factor 2
point mutation
N VS T2-T4
24476821
NOTCH2
Q04721
Neurogenic locus notch homolog protein 2
point mutation
Ta-T1 Vs T2-T4, LN0/+
26769750
NRAS
P01111
GTPase Nras
point mutation
Ta,T1 VS T2,T3,T4
25533674
PAIP1
Q9H074
Polyadenylate-binding protein-interacting protein 1
null mutation
N VS T2-T4
24476821
PAIP1
Q9H074
Polyadenylate-binding protein-interacting protein 1
point mutation
N VS T2-T4
24476821
PIK3CA
P42336
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
point mutation
N VS T2-T4
24476821
PIK3CA
P42336
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
point mutation
Ta,T1 VS T2,T3,T4
25533674
PIK3R1
P27986
Phosphatidylinositol 3-kinase regulatory subunit alpha
mutation
Ta,T1 VS T2,T3,T4
25533674
PTCH1
Q13635
Protein patched homolog 1
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
PTEN
P60484
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
hemizygous deletion
Ta,T1 VS T2,T3,T4
25533674
PTEN
P60484
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
homozygous deletion
Ta,T1 VS T2,T3,T4
25533674
RB1
P06400
Retinoblastoma-associated protein
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
RB1
P06400
Retinoblastoma-associated protein
null mutation
N VS T2-T4
24476821
RB1
P06400
Retinoblastoma-associated protein
point mutation
N VS T2-T4
24476821
RHOA
P61586
Transforming protein RhoA
point mutation
N VS T2-T4
24476821
RHOB
P62745
Rho-related GTP-binding protein RhoB
point mutation
N VS T2-T4
24476821
RUNX3
Q13761
Runt-related transcription factor 3
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
RXRA
P19793
Retinoic acid receptor RXR-alpha
point mutation
N VS T2-T4
24476821
RXRA
P19793
Retinoic acid receptor RXR-alpha
mutation
Ta,T1 VS T2,T3,T4
25533674
STAG2
Q8N3U4
Cohesin subunit SA-2
null mutation
N VS T2-T4
24476821
STAG2
Q8N3U4
Cohesin subunit SA-2
point mutation
N VS T2-T4
24476821
STAG2
Q8N3U4
Cohesin subunit SA-2
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
TERT
O14746
Telomerase reverse transcriptase
promoter point mutation
Ta,T1 VS T2,T3,T4
24018021
TP53
P04637
Cellular tumor antigen p53
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
TP53
P04637
Cellular tumor antigen p53
null mutation
N VS T2-T4
24476821
TP53
P04637
Cellular tumor antigen p53
point mutation
N VS T2-T4
24476821
TSC1
Q92574
Hamartin
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
TSC1
Q92574
Hamartin
null mutation
N VS T2-T4
24476821
TSC1
Q92574
Hamartin
point mutation
N VS T2-T4
24476821
TSC2
P49815
Tuberin
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
TXNIP
Q9H3M7
Thioredoxin-interacting protein
inactivating mutation
Ta,T1 VS T2,T3,T4
25533674
TXNIP
Q9H3M7
Thioredoxin-interacting protein
null mutation
N VS T2-T4
24476821
TXNIP
Q9H3M7
Thioredoxin-interacting protein
point mutation
N VS T2-T4
24476821
ZFP36L1
Q07352
Zinc finger protein 36, C3H1 type-like 1
null mutation
N VS T2-T4
24476821
ZFP36L1
Q07352
Zinc finger protein 36, C3H1 type-like 1
point mutation
N VS T2-T4
24476821
ZFR2
Q9UPR6
Zinc finger RNA-binding protein 2
point mutation
N VS T2-T4
24476821


Marie