Examples


Molecular Pathways in Muscle Invasive Bladder Cancer


KEGG and Reactome pathways significantly enriched in muscle invasive bladder carcinoma

Download Data
KEGG pathway term
Total # of MIBC-PPI features
Bonferroni p-value
Source
PI3K-Akt signaling pathway
79
5.97e-38
KEGG:04151
Signaling by SCF-KIT
48
2.5e-31
REACTOME:111040
ErbB signaling pathway
62
1.49e-30
KEGG:04012
Focal adhesion
55
7.87e-29
KEGG:04510
Signaling by PDGF
51
2.59e-27
REACTOME:16888
NGF signalling via TRKA from the plasma membrane
52
8.51e-27
REACTOME:12056
Signaling by EGFR in Cancer
48
7.71e-26
REACTOME:9417
Signaling by FGFR in disease
48
9.98e-26
REACTOME:355289
Signalling by NGF
58
1.12e-24
REACTOME:11061
DAP12 signaling
45
1.51e-24
REACTOME:147814
FoxO signaling pathway
40
2.93e-23
KEGG:04068
mTOR signaling pathway
28
1.11e-20
KEGG:04150
Signaling by VEGF
38
2.65e-20
REACTOME:12529
IGF1R signaling cascade
31
4.27e-19
REACTOME:150210
HIF-1 signaling pathway
33
7.39e-19
KEGG:04066
IRS-related events triggered by IGF1R
30
2.01e-18
REACTOME:150203
Neurotrophin signaling pathway
32
1.29e-16
KEGG:04722
Insulin signaling pathway
34
2.38e-16
KEGG:04910
TNF signaling pathway
30
8.82e-16
KEGG:04668
MAPK signaling pathway
46
2.6e-15
KEGG:04010
Signal Transduction
160
2.46e-14
REACTOME:111102
p53 signaling pathway
33
4.65e-14
KEGG:04115
Rap1 signaling pathway
39
9.68e-14
KEGG:04015
Cellular responses to stress
46
1.59e-13
REACTOME:120956
Ras signaling pathway
43
1.38e-12
KEGG:04014
SHC-mediated signalling
16
1.39e-12
REACTOME:661
Signaling by Interleukins
26
9.74e-12
REACTOME:22232
FCERI mediated MAPK activation
17
1.54e-11
REACTOME:163701
Adherens junction
21
4.04e-11
Literature
Cellular Senescence
32
1.12e-10
Literature
GRB2 events in ERBB2 signaling
14
2.64e-10
Literature
Activation of BH3-only proteins
13
3.02e-10
Literature
Signaling pathways regulating pluripotency of stem cells
27
6.65e-10
KEGG:04550
Oxytocin signaling pathway
28
1.8e-09
KEGG:04921
Hippo signaling pathway
27
4.93e-09
KEGG:04390
AMPK signaling pathway
24
8.1e-09
KEGG:04152
PKB-mediated events
13
9.79e-09
REACTOME:456
Apoptosis
27
1.07e-08
REACTOME:578
Tight junction
25
1.39e-08
KEGG:04530
GRB2 events in EGFR signaling
11
1.7e-08
REACTOME:12606
SOS-mediated signalling
11
1.7e-08
REACTOME:524
Chemokine signaling pathway
29
2.5e-08
KEGG:04062
RAF/MAP kinase cascade
10
2.87e-08
REACTOME:634
Signalling to p38 via RIT and RIN
11
3.29e-08
REACTOME:12077
GnRH signaling pathway
20
4.48e-08
KEGG:04912
ARMS-mediated activation
11
6.09e-08
REACTOME:12002
Extracellular matrix organization
41
7.3e-08
REACTOME:118779
Toll-like receptor signaling pathway
32
9.65e-08
KEGG:04620
Signalling to ERKs
14
1.3e-07
REACTOME:12058
Frs2-mediated activation
14
1.88e-07
REACTOME:12076
Activation of BAD and translocation to mitochondria
9
2.11e-07
REACTOME:549
Nuclear Receptor transcription pathway
14
1.15e-06
REACTOME:15525
MyD88-independent TLR3/TLR4 cascade
19
1.24e-06
REACTOME:6809
TRIF-mediated TLR3/TLR4 signaling
19
1.24e-06
REACTOME:25281
TGF-beta signaling pathway
17
1.68e-06
KEGG:04350
Activation of the AP-1 family of transcription factors
7
4.24e-06
REACTOME:21326
MEK activation
6
7.22e-06
REACTOME:962
Regulation of actin cytoskeleton
27
1.04e-05
KEGG:04810
Activated TLR4 signalling
19
1.22e-05
REACTOME:6890
S6K1-mediated signalling
7
2.62e-05
REACTOME:6754
Double-Strand Break Repair
9
2.65e-05
REACTOME:2054
Release of eIF4E
6
2.8e-05
REACTOME:6836
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
16
3.57e-05
REACTOME:25024
Gap junction
16
5.88e-05
KEGG:04540
Cell Cycle
45
0.000255
REACTOME:115566
Oncogene Induced Senescence
9
0.000368
REACTOME:169325
Wnt signaling pathway
19
0.000393
KEGG:04310
Aldosterone-regulated sodium reabsorption
10
0.000452
KEGG:04960
NF-kappa B signaling pathway
15
0.000466
KEGG:04064
Endocytosis
24
0.00048
KEGG:04144
Adipocytokine signaling pathway
13
0.000605
KEGG:04920
Cell-Cell communication
18
0.000636
REACTOME:111155
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
6
0.000813
REACTOME:407
Non-integrin membrane-ECM interactions
11
0.000946
REACTOME:163874
ECM-receptor interaction
14
0.0014315
KEGG:04512
Syndecan interactions
7
0.00198205
REACTOME:163942
cAMP signaling pathway
22
0.00201511
KEGG:04024
NOD-like receptor signaling pathway
11
0.00266882
KEGG:04621
Platelet activation
37
0.00275022
KEGG:04611
Pre-NOTCH Transcription and Translation
8
0.00306128
REACTOME:118568
Cell surface interactions at the vascular wall
15
0.0059617
REACTOME:12051
Tie2 Signaling
6
0.0135166
REACTOME:12621
Oxidative Stress Induced Senescence
15
0.0150892
REACTOME:169436
cGMP-PKG signaling pathway
18
0.019489
KEGG:04022
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
9
0.0200411
REACTOME:75913
Homologous recombination
7
0.0234085
KEGG:03440
Signaling by NOTCH
14
0.0248092
REACTOME:299
Anchoring fibril formation
4
0.0253372
REACTOME:150268
p38MAPK events
5
0.0292247
REACTOME:12065
CD209 (DC-SIGN) signaling
6
0.0359412
REACTOME:355503
DNA Damage/Telomere Stress Induced Senescence
11
0.0497093
REACTOME:169185


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