Examples


Tumour Suppressor Genes

Download Data

All molecules displayed are selected based on the significance criteria.

Gene name
Protein name
Publication Reference
Type of mutation
Comparison
mRNA expression
Protein expression
Frequency
APC
Adenomatous polyposis coli protein
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
ARID1A
AT-rich interactive domain-containing protein 1A
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
ARID1A
AT-rich interactive domain-containing protein 1A
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
ARID1A
AT-rich interactive domain-containing protein 1A
24476821
point mutation
N VS T2-T4
up
N/A
N/A
ATM
Serine-protein kinase ATM
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
BTG2
Protein BTG2
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
BTG2
Protein BTG2
24476821
point mutation
N VS T2-T4
up
N/A
N/A
CCND3
G1/S-specific cyclin-D3
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
CCND3
G1/S-specific cyclin-D3
24476821
point mutation
N VS T2-T4
up
N/A
N/A
CDKN1A
Cyclin-dependent kinase inhibitor 1
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
CDKN1A
Cyclin-dependent kinase inhibitor 1
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
CDKN1A
Cyclin-dependent kinase inhibitor 1
24476821
point mutation
N VS T2-T4
up
N/A
N/A
CDKN2A
Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
25533674
hemizygous deletion
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
CDKN2A
Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
25533674
homozygous deletion
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
CDKN2A
Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
25533674
mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
CDKN2A
Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
CDKN2A
Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
24476821
point mutation
N VS T2-T4
up
N/A
N/A
CTNNB1
Catenin beta-1
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
ELF3
ETS-related transcription factor Elf-3
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
ELF3
ETS-related transcription factor Elf-3
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
ELF3
ETS-related transcription factor Elf-3
24476821
point mutation
N VS T2-T4
up
N/A
N/A
EP300
Histone acetyltransferase p300
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
EP300
Histone acetyltransferase p300
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
EP300
Histone acetyltransferase p300
24476821
point mutation
N VS T2-T4
up
N/A
N/A
ERBB3
Receptor tyrosine-protein kinase erbB-3
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
ERBB3
Receptor tyrosine-protein kinase erbB-3
24476821
point mutation
N VS T2-T4
up
N/A
N/A
ERCC2
TFIIH basal transcription factor complex helicase XPD subunit
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
ERCC2
TFIIH basal transcription factor complex helicase XPD subunit
24476821
point mutation
N VS T2-T4
up
N/A
N/A
FBXW7
F-box/WD repeat-containing protein 7
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
FBXW7
F-box/WD repeat-containing protein 7
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
FBXW7
F-box/WD repeat-containing protein 7
24476821
point mutation
N VS T2-T4
up
N/A
N/A
FOXA1
Hepatocyte nuclear factor 3-alpha
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
FOXA1
Hepatocyte nuclear factor 3-alpha
24476821
point mutation
N VS T2-T4
up
N/A
N/A
FOXQ1
Forkhead box protein Q1
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
FOXQ1
Forkhead box protein Q1
24476821
point mutation
N VS T2-T4
up
N/A
N/A
GPC5
Glypican-5
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
GPC5
Glypican-5
24476821
point mutation
N VS T2-T4
up
N/A
N/A
HORMAD1
HORMA domain-containing protein 1
24476821
point mutation
N VS T2-T4
down
N/A
N/A
HORMAD1
HORMA domain-containing protein 1
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
KDM6A
Lysine-specific demethylase 6A
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
KDM6A
Lysine-specific demethylase 6A
24476821
point mutation
N VS T2-T4
up
N/A
N/A
KDM6A
Lysine-specific demethylase 6A
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
KLF5
Krueppel-like factor 5
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
KLF5
Krueppel-like factor 5
24476821
point mutation
N VS T2-T4
down
N/A
N/A
KLF5
Krueppel-like factor 5
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
KMT2D
Histone-lysine N-methyltransferase 2D
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
KMT2D
Histone-lysine N-methyltransferase 2D
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
KMT2D
Histone-lysine N-methyltransferase 2D
24476821
point mutation
N VS T2-T4
up
N/A
N/A
MDM2
E3 ubiquitin-protein ligase Mdm2
25533674
amplification
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
NFE2L2
Nuclear factor erythroid 2-related factor 2
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
NFE2L2
Nuclear factor erythroid 2-related factor 2
24476821
point mutation
N VS T2-T4
up
N/A
N/A
PAIP1
Polyadenylate-binding protein-interacting protein 1
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
PAIP1
Polyadenylate-binding protein-interacting protein 1
24476821
point mutation
N VS T2-T4
up
N/A
N/A
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
24476821
point mutation
N VS T2-T4
up
N/A
N/A
PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha
25533674
mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
PTCH1
Protein patched homolog 1
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
25533674
hemizygous deletion
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
25533674
homozygous deletion
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
RB1
Retinoblastoma-associated protein
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
RB1
Retinoblastoma-associated protein
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
RB1
Retinoblastoma-associated protein
24476821
point mutation
N VS T2-T4
up
N/A
N/A
RHOA
Transforming protein RhoA
24476821
point mutation
N VS T2-T4
up
N/A
N/A
RUNX3
Runt-related transcription factor 3
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
RXRA
Retinoic acid receptor RXR-alpha
24476821
point mutation
N VS T2-T4
up
N/A
N/A
STAG2
Cohesin subunit SA-2
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
STAG2
Cohesin subunit SA-2
24476821
point mutation
N VS T2-T4
up
N/A
N/A
STAG2
Cohesin subunit SA-2
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
TP53
Cellular tumor antigen p53
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
down
N/A
TP53
Cellular tumor antigen p53
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
TP53
Cellular tumor antigen p53
24476821
point mutation
N VS T2-T4
up
N/A
N/A
TSC1
Hamartin
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
TSC1
Hamartin
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
TSC1
Hamartin
24476821
point mutation
N VS T2-T4
up
N/A
N/A
TSC2
Tuberin
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
TXNIP
Thioredoxin-interacting protein
25533674
inactivating mutation
Ta,T1 VS T2,T3,T4
N/A
N/A
N/A
TXNIP
Thioredoxin-interacting protein
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
TXNIP
Thioredoxin-interacting protein
24476821
point mutation
N VS T2-T4
up
N/A
N/A
ZFP36L1
Zinc finger protein 36, C3H1 type-like 1
24476821
null mutation
N VS T2-T4
N/A
N/A
N/A
ZFP36L1
Zinc finger protein 36, C3H1 type-like 1
24476821
point mutation
N VS T2-T4
up
N/A
N/A
ZFR2
Zinc finger RNA-binding protein 2
24476821
point mutation
N VS T2-T4
down
N/A
N/A


Marie